Animal model of continuous peritoneal lavage with vacuum peritoneostomy

Rodrigues, Adilson Costa; Santos, Luana Carla dos; Otsuki, Denise Aya; Saad, Karen Ruggeri; Saad, Paulo Fernandes; Montero, Edna Frasson de Souza; Utiyama, Edivaldo Massazo

doi:10.1590/s0102-865020170060000007

Cited by 2 publications

(3 citation statements)

References 12 publications

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“…In a recent publication 12, we described a continuous peritoneal lavage model associated with vacuum peritoneostomy that aimed to solve the problems observed in previous peritoneal lavage techniques. The model was able to maintain stability of the lavage system for 9 hours without leaks or obstruction and resulted in adequate clearance.…”

Section: Discussionmentioning

confidence: 99%

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Continuous peritoneal lavage with vacuum peritoneostomy: an experimental study

Rodrigues

Saad

et al. 2019

Clinics

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OBJECTIVE: Despite advances in diffuse peritonitis treatment protocols, some cases develop unfavorably. With the advent of vacuum therapy, the use of laparostomy to treat peritonitis has gained traction. Another treatment modality is continuous peritoneal lavage. However, maintaining this technique is difficult and has been associated with controversial results. We propose a new model of continuous peritoneal lavage that takes advantage of the features and benefits of vacuum laparostomy. METHOD: Pigs (Landrace and Large White) under general anesthesia were submitted to laparostomy through which a multiperforated tube was placed along each flank and exteriorized in the left and lower right quadrants. A vacuum dressing was applied, and intermittent negative pressure was maintained. Peritoneal dialysis solution (PDS) was then infused through the tubes for 36 hours. The stability of peritoneostomy with intermittent infusion of fluids, the system resistance to obstruction and leakage, water balance, hemodynamic and biochemical parameters were evaluated. Fluid disposition in the abdominal cavity was analyzed through CT. RESULTS: Even when negative pressure was not applied, the dressing maintained the integrity of the system, and there were no leaks or blockage of the catheters during the procedure. The aspirated volume by vacuum laparostomy was similar to the infused volume (9073.5±1496.35 mL versus 10165±235.73 mL, p =0.25), and there were no major changes in hemodynamic or biochemical analysis. According to CT images, 60 ml/kg PDS was sufficient to occupy all intra-abdominal spaces. CONCLUSION: Continuous peritoneal lavage with negative pressure proved to be technically possible and may be an option in the treatment of diffuse peritonitis.

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Section: Discussionmentioning

confidence: 99%

“…The animals were submitted to a continuous peritoneal lavage technique associated with vacuum peritoneostomy, as previously described 12. They were submitted to laparostomy through which a 4.8 mm multiperforated tube was placed along each flank and exteriorized in the lower left and lower right quadrants.…”

Section: Methodsmentioning

confidence: 99%

Continuous peritoneal lavage with vacuum peritoneostomy: an experimental study

Rodrigues

Saad

et al. 2019

Clinics

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“…Pigs, which offer a conveniently large anatomy and relatively large body fluid and tissue resources, are being increasingly adopted as a model in scientific research (5, 15, 25). For research purposes, farm pigs of various breeds are used, including Landrace, Yorkshire, Duroc, Hampshire, and miniature and hybrid.…”

Section: Introductionmentioning

confidence: 99%

Haemodynamics imaging of swine segmental kidney artery using duplex Doppler technique

Aleksiewicz

Lutnicki

Bojarski³

et al. 2019

Journal of Veterinary Research

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Introduction: The aim of the study was to assess the usefulness of duplex Doppler to objectify swine renal arterial flow in physiological conditions. The pig kidney was selected for its morphological similarities to the human and for the results therefore offering data to wider research. Material and Methods: Six White Large x Landrace sows, of 48.5–53 kg b.w. were used. Vascular flow parameters were acquired with a convex probe USG device with a duplex Doppler function using pulsed waves (frequency range of 5–7.5 MHz). Segmental kidney arterial flow was measured. Results: The RI values were within the 0.57 (min) to 0.6 (max) range, ̄xRI was 0.58 (±0.014), and the SD2 value was 0.0002. The PI index values ranged from 1.21 (min) to 1.3 (max), and ̄xRI was 1.24 (±0.035). The value of SD2 was 0.00123. In the S/D index, the results fell between 2.2 (min) and 2.49 (max), with ̄xS/D of 2.29 (±0.117). The value of variance SD2 was 0.0139. A double analysis of correlation between indices showed this to be almost certain and highly positive as confirmed by high correlation coefficients: r RI & PI 0.857, rhoRI & PI 0.739, rRI & S/D 0.930, rhoRI & S/D 0.941, rPI & S/D 0.913, and rhoPI & S/D 0.754. The segmental kidney arterial flow spectrum evinced falls in PSV and PSV/LDV ratio, also noticed in the filling of the spectral window, comparing the renal to an interlobar artery. Conclusion: Swine were selected because of renal anatomical and haemodynamic similarity to humans. The most relevant values and indices approximated those in humans. The study anaesthetic protocol had a minor influence on the average RI, PI, and S/D indices.

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Animal model of continuous peritoneal lavage with vacuum peritoneostomy

Abstract: The continuous peritoneal lavage technique with vacuum peritoneostomy is feasible and presents adequate clearance.

Cited by 2 publications

References 12 publications

Continuous peritoneal lavage with vacuum peritoneostomy: an experimental study

Continuous peritoneal lavage with vacuum peritoneostomy: an experimental study

Haemodynamics imaging of swine segmental kidney artery using duplex Doppler technique

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