2017
DOI: 10.1590/s0102-865020170050000007
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Abstract: Myocardial ischemic post-conditioning protects the lung against myocardial ischemia/reperfusion-induced damage by activating GSK-3β 1 Abstract Purpose: To investigate whether modulating GSK-3β could attenuate myocardial ischemia reperfusion injury (MIRI) induced acute lung injury (ALI) and analyze the underlying mechanism. Methods: Male SD rats were subjected to MIRI with or without myocardial ischemic postconditioning in the presence or absence of GSK-3β inhibitor. GSK-3β inhibitor was injected peritoneally 1… Show more

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Cited by 8 publications
(7 citation statements)
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“…A number of studies have shown that MIRI was able to induce ALI in rat models, which is consistent with our results [4,5,22,23]. The lung appeared to be the frailest organ in uenced by MIRI.…”
Section: Discussionsupporting
confidence: 92%
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“…A number of studies have shown that MIRI was able to induce ALI in rat models, which is consistent with our results [4,5,22,23]. The lung appeared to be the frailest organ in uenced by MIRI.…”
Section: Discussionsupporting
confidence: 92%
“…This study also has some limitations. First, we built the 120-minute ischemia and following 30-minute reperfusion protocol, which was a common protocol to establish MIRI, and a previous study observed apoptosis in lungs using this protocol [5]. However, other timepoints for building a MIRI-induced lung pyroptosis model were not assessed.…”
Section: Discussionmentioning
confidence: 99%
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“…PMNs, which are involved in multiple non-infectious inflammatory processes including the response to MI/RI, serves as a key effector in the innate immune system (30). Following MI/RI, a large increase in the number of circulating PMNs occurred, which could predict the major adverse cardiac events in MI/RI patients with larger infarct size and worse cardiac function (31).…”
Section: Discussionmentioning
confidence: 99%
“…The surgical protocol was carried out in accordance with the previous method with slight modifications [ 23 ]. In brief, Sprague-Dawley rats were anaesthetized with pentobarbital (40 mg/kg) by intraperitoneal injection.…”
Section: Methodsmentioning
confidence: 99%