Effect of biosynthesized silver nanoparticles by Garcinia mangostana extract against human breast cancer cell line MCF-7

Abstract

Breast cancer is the greatest common malignancy in females. This syndrome represents a serious public health problem that needs additional study to define its prediction and specific treatment. MCF-7 is a usually used breast cancer cell line that has been spread for many years by multiple groups. It shows to be a suitable model cell line for breast cancer studies worldwide, including those concerning anticancer. Anticancer and anti-inflammatory influences are important to treat the threats of chronic inflammation related with chronic diseases. Natural products have made and are remaining to make vital influences to the search for new anticancer agents. The use of natural foodstuffs in relationship with green nanoparticles has drawn attention because of its easy and eco-friendly protocol. Therefore, we aimed to investigate the antiproliferative activity of silver nanoparticles biosynthesized by mangosteen peel extract (MPE) on human breast cancer cell line (MCF-7) using [3-(4, 5-dimethylthiazolyl)-2, 5-diphenyl-tetrazolium bromide (MTT) method. In the present study serial concentrations (5, 10, 15, 50, 70, µg/mL) of cells biosynthesized silver nanoparticles by (MPE) was tested against MCF-7 cell lines showed a cytotoxic effects, morphological degeneration, damaging and has more effectiveness against breast cancer cells. The results showed a substantial a high reducing power, a sensible antiproliferative role and antioxidant activity. The results showed that silver nanoparticles biosynthesized by mangosteen peel extract (MPE) can be regarded as a suitable candidate for designing anticancer pharmaceutical preparations.

Effect of biosynthesised silver nanoparticles as sterilant on physiological and biochemical characteristics in micropropagation of Musa sapientum L.

“…TEM revealed that the AgNPs were spherical and polydispersed (figure 2(A)) with the size distribution of the AgNPs in the range of 5-47 nm and an average size of 23.1 ± 6.8 nm. The size and shape of the AgNPs were significantly different from previous studies [33][34][35][36], probably because of the synthetic conditions including the concentration of AgNO 3 , synthesis temperature, reaction time, and the mangosteen peel extraction procedure. In addition, the shape of the AgNPs was associated with the efficiency of antibacterial activity.…”

Green synthetic photo-irradiated chitin-silver nanoparticles for antimicrobial applications

“…Among various materials, nanoscale environmentally friendly methods to synthesize AgNPs, avoiding the use of hazardous chemicals and solvents for various biomedical applications [13,14]. Green chemical routes using extracts from natural resources such as mango, grape, pomegranate, pineapple, ginger, imperial crown leaves, moringa oleifera (drumstick tree), and citrus macroptera (wild orange), as well as chitin and chitosan, have shown promise in serving as both reducing and stabilizing agents, as evident from the literature [15][16][17][18][19].…”