Antioxidant and anti-diabetic properties of Spirulina platensis produced in Turkey

Abstract

Spirulina produced in Turkey has a high antioxidant capacity determined by the three common methods (ABTS, CUPRAC, and DPPH). The major phenolics found in Spirulina were acacetin (53.62%) and pinocembrin (41.28%). The bio-accessibility values of the phenolic compounds in Spirulina were approximately 60%. PUFA's are the significant antioxidant compounds to prevent lipid peroxidation. Spirulina has been found to reduce blood sugar and oxidative stress due probably to the high amount of ω-6 PUFA. By the treatment of Spirulina, the levels of antioxidant enzymes (GSH-Px and SOD) were increased 240 and 60% in the healthy rats, while 19 and 59% in the diabetics. In diabetic rats fed with Spirulina, glucose, triglyceride, total cholesterol levels in blood and malondialdehyde content in body tissues were decreased by 20, 31, 22 and up to 56%, respectively. In-vitro and in-vivo tests have shown that Spirulina has anti-hyperglycaemic, anti-hyperlipidaemia and antioxidative effects on diabetic rats.

Influencia de la Spirulina (Arthrospira platensis) como alimento funcional en enfermedades crónicas

“…Al ser suministrado mejora la respuesta de la glucosa esto debido a la ficocianina pues va a activar la glucoquinasa y la señalización de la insulina en el hígado y páncreas, lo que conducirá a disminuir la glicemia. (20) (21) Al ser un alimento con altos componentes en macro y micronutrientes esenciales en este caso uno de ellos es la PUFA pues contiene importantes compuestos antioxidantes para prevenir la peroxidación de lípidos, así también se ha demostrado que la Spirulina disminuye la glucemia y el estrés oxidativo ya que presenta un gran aporte de ω-6 PUF para sobrellevar un buen estado nutricional. Se realizó un estudio en el cual se tomó en cuenta 59 ratas diabéticas que fueron sometidas a un tratamiento con Spirulina, se comprobó que los niveles de enzimas antioxidantes se encontraban en aumento, niveles de glucosa, triglicéridos y colesterol total en sangre y el contenido de malondialdehído en los tejidos corporales disminuyeron en un 20, 31, 22 y hasta un 56%, respectivamente.…”

“…Las pruebas in vitro e in vivo han demostrado que la espirulina tiene efectos antihiperglucémicos, antihiperlipidémicos y antioxidantes en las ratas diabéticas. (21) (22) Carrera de Medicina. Facultad de Ciencias de la Salud.…”

Hepatoprotective effect of clam (Corbicula fluminea) protein hydrolysate on alcohol-induced liver injury in mice and partial identification of a hepatoprotective peptide from the hydrolysate

“…The hepatic levels of malondialdehyde (MDA) and glutathione (GSH) are considered as typical indexes of antioxidant status of tissues (Jiang et al, 2019). GSH is the major non-protein thiol that plays a vital role in maintaining the antioxidant defense mechanism in the body (Guldas et al, 2021). MDA, the end product of lipid peroxidation, is widely used as a marker of lipid peroxidation injury.…”

Assessment of Different Oxidative, Endocrinological and Biochemical Parameters using Catharanthus Roseus on Rats

“…The results of immediate study discovered a moderate but non-significant statistical (P>0.05) shift in groups A, B and C respectively (Fig 1). [29][30]…”