Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change

Lira, Marcia Lanzoni Alvarenga; Almeida, Mariana Abdo de; Reis-Feroldi, Michele Maria; Rocha, Jeanine Alvarenga

doi:10.1590/abd1806-4841.20198299

Cited by 3 publications

(4 citation statements)

References 8 publications

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“…The skin is a very rare site of metastatic involvement in PTC; there are only a few case reports in the English literature to date (Table 1) [3][4][5][7][8][9][10][11][12][13][14][15][16][17]. Skin metastasis might manifest as a pimple, slowly growing nodule, or rarely bleeding ulcer [16].…”

Section: Discussionmentioning

confidence: 99%

Skin Metastasis Occurring 30 Years After Thyroidectomy for Papillary Thyroid Carcinoma

Alwhaid¹,

Mhish²,

Tunio³

et al. 2022

Cureus

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The skin is an extremely rare site of metastasis from papillary thyroid carcinoma (PTC) and is linked to underlying disseminated malignancy, which reflects a dismal prognosis. We present the case of a 70-yearsold Saudi female who presented at our clinic with an eight-month history of two painful and itchy skin nodules over the scalp and the medial aspect of the right arm. She had a history of total thyroidectomy for PTC 30 years prior. Computed tomography-positron emission tomography showed multiple fluorodeoxyglucose avid lung and skeletal metastases. This case highlights the fact that skin nodules in a patient with a history of PTC should be assessed carefully with a high suspicion of skin metastasis to avoid any delay in treatment.

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Section: Discussionmentioning

confidence: 99%

Skin Metastasis Occurring 30 Years After Thyroidectomy for Papillary Thyroid Carcinoma

Alwhaid¹,

Mhish²,

Tunio³

et al. 2022

Cureus

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“…The rarest secondary sites of thyroid cancer involvement that have been cited are at mammary level, renal area as well as pancreas, adrenals, cerebral, ovarian, parotids, and teguments (11,12,13). Cutaneous location varies from neck and head (majority) to exceptional sites as chest wall and of variable incidence for scalp (11,12,14,15). Underling neck muscle or Meckel's cave in association with local teguments has also been reported (15,16).…”

Section: Skin Metastasesmentioning

confidence: 99%

“…Biopsy and consecutive histological report are essential for diagnosis in cases without an evident connection to the thyroid malignancy (16). In thyroid neoplasia, skin metastases are rarely seen as the first sign of disease, but they may represent the sign of relapse (14).…”

Section: Skin Metastasesmentioning

confidence: 99%

“…The presence of newly detected skin lump may be incidental and the connection with thyroid malignancy may not be evident at admission (14,15,16). Lately, incidental findings of solid, cystic or mix consistence, are not only clinically, but also radiological detected and their identification has an explosive incidence during last decades (22,23,24).…”

Section: Incidental Findingsmentioning

confidence: 99%

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Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Şandru¹,

Valea²,

Albu³

et al. 2020

Ro J Med Pract.

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Skin metastases are not typical. Malignancies like mammary cancer (most frequent in females) and pulmonary neoplasia (most frequent in males) represent the majority and exceptional findings are in those originating from thyroid, prostate, ovaries and oesophagus, usually in advanced, generally disseminated stages, with a poor prognosis. It may be found more often in elderly patients. We aim to present some practical aspects of skin metastases in thyroid cancer that originates from follicular thyroid epithelium. This is a brief literature review. The level of evidence is poor since most data is provided from cases reports. Cutaneous malignant lumps are rarely the first sign of disease, mostly associating a cancer relapse. The location varies from neck and head (majority) to exceptional sites as chest wall and of variable rate for scalp. Underling neck muscle or Meckel's cave metastasis may be associated. The lesion is usually a lump of medium to small size, sometimes of papular appearance, without local pain (but depends on the site); it may associate erythema. The diagnosis is difficult unless an index of suspicion is positive (in which case whole body radioiodine scintigram may be useful). Biopsy and histological report are essential for diagnosis especially in cases without an evident connection to a prior/synchronous thyroid malignancy. Knowing the exceptional prevalence, the need for awareness in this particular topic is connected with a multidisciplinary daily practice.

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Breast metastasis in follicular thyroid cancer patient

et al. 2022

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Follicular thyroid carcinoma metastatic to skin: a small papule and a big diagnostic change

Cited by 3 publications

References 8 publications

Skin Metastasis Occurring 30 Years After Thyroidectomy for Papillary Thyroid Carcinoma

Skin Metastasis Occurring 30 Years After Thyroidectomy for Papillary Thyroid Carcinoma

Skin metastasis as incidental finding in follicular epithelium derived – thyroid cancer

Breast metastasis in follicular thyroid cancer patient

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