2019
DOI: 10.1590/abd1806-4841.20197414
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Abstract: BackgroundSentinel lymph node biopsy in thin invasive primary cutaneous melanoma (up to 1mm thick) is a controversial subject. The presence of tumor-infiltrating lymphocytes could be a factor to be considered in the decision to perform this procedure.ObjectiveTo evaluate the association between the presence of tumor-infiltrating lymphocytes and lymph node metastases caused by thin primary cutaneous melanoma.MethodsCross-sectional study with 137 records of thin invasive primary cutaneous melanoma submitted to s… Show more

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Cited by 11 publications
(11 citation statements)
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“…This is no surprising finding, as it is known that ulceration is a negative prognostic factor and associated with higher BT as well, both of which is known to increase the likelihood of a positive SLNB. 25,26 No significant difference in OS was found between patients with only INN and patients with negative SLNB, corroborating previous studies, 12,13 while patients with positive SLNB had significantly worse OS as expected. However, patients with INN in our study were significantly younger compared with patients with negative and positive SLNB, which may have affected OS.…”
Section: Discussionsupporting
confidence: 88%
See 1 more Smart Citation
“…This is no surprising finding, as it is known that ulceration is a negative prognostic factor and associated with higher BT as well, both of which is known to increase the likelihood of a positive SLNB. 25,26 No significant difference in OS was found between patients with only INN and patients with negative SLNB, corroborating previous studies, 12,13 while patients with positive SLNB had significantly worse OS as expected. However, patients with INN in our study were significantly younger compared with patients with negative and positive SLNB, which may have affected OS.…”
Section: Discussionsupporting
confidence: 88%
“…Regarding ulceration, we found a nearly similar ulceration rate between INN‐ and SLNB‐negative patients (respectively 19.2% and 20.3%), compared with 35.1% in SLNB‐positive patients ( P < 0.001). This is no surprising finding, as it is known that ulceration is a negative prognostic factor and associated with higher BT as well, both of which is known to increase the likelihood of a positive SLNB …”
Section: Discussionmentioning
confidence: 62%
“…Studies have generally not shown that TILs are predictive of SLN metastases, 24‐28 but TILs were not considered in the majority of these studies. However, all studies that did evaluate TILs showed that the presence of TILs was predictive of a lower positive SLN rate 5,8‐14 . The current study also confirms the lower likelihood of SLN metastasis with the presence of TILs and suggests that TILs are a favorable predictive marker for the SLN status.…”
Section: Discussionsupporting
confidence: 75%
“…For instance, Azimi et al 5 showed that an increasing TIL grade from 0 to 3 was significantly prognostic of better 5‐year melanoma‐specific survival (MSS) 5 . Additionally, some studies have demonstrated that the presence of TILs predicts a negative sentinel lymph node biopsy (SLNB) 5,8‐14 . However, other studies evaluating TILs in melanoma have found no correlation between survival and TILs, 8,11,13,15 and most studies evaluating SLNB in melanoma have been unable to evaluate whether TILs are predictive of the sentinel lymph node (SLN) status.…”
Section: Introductionmentioning
confidence: 99%
“…Microsatellites are a rarely present pathologic feature associated with poor prognosis and are more likely found in thicker melanoma (78). Four studies in our meta-analysis including 1411 patients with thin melanoma reported data on microsatellites (18,25,32,41). Two of them demonstrated a remarkable increase in SLN positive rate when microsatellites were present, but none of the four studies found it statistically significant because of the infrequence of events.…”
Section: Discussionmentioning
confidence: 81%