2018
DOI: 10.1590/abd1806-4841.20186340
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Skin's innate immunity is the initial activator of immune response mechanisms, influencing the development of adaptive immunity. Some contact allergens are detected by Toll-like receptors (TLRs) and inflammasome NLR3. Keratinocytes participate in innate immunity and, in addition to functioning as an anatomical barrier, secrete cytokines, such as TNF, IL-1β, and IL-18, contributing to the development of Allergic Contact Dermatitis. Dendritic cells recognize and process antigenic peptides into T cells. Neutrophi… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
2
1
1
1

Citation Types

0
27
0

Year Published

2019
2019
2023
2023

Publication Types

Select...
6
3

Relationship

0
9

Authors

Journals

citations
Cited by 32 publications
(27 citation statements)
references
References 82 publications
0
27
0
Order By: Relevance
“…Other studies have shown that these cytokines are produced by macrophages and effector T cells 32,33 , and that TLR4 increases the sensitivity of contact dermatitis. TLR4 is expressed in several non-immune cells such as keratinocytes and sebocytes, and antigen-presenting cells such as macrophages and dendritic cells (DCs) [33][34][35] , and is required for the activation of the innate immune system, which is necessary for the sensitization of allergens 34,[36][37][38] . When the innate immune system is activated, the migration of dermal DCs to regional lymph nodes, which is the sensitisation phase of contact dermatitis, is initiated.…”
Section: Discussionmentioning
confidence: 99%
“…Other studies have shown that these cytokines are produced by macrophages and effector T cells 32,33 , and that TLR4 increases the sensitivity of contact dermatitis. TLR4 is expressed in several non-immune cells such as keratinocytes and sebocytes, and antigen-presenting cells such as macrophages and dendritic cells (DCs) [33][34][35] , and is required for the activation of the innate immune system, which is necessary for the sensitization of allergens 34,[36][37][38] . When the innate immune system is activated, the migration of dermal DCs to regional lymph nodes, which is the sensitisation phase of contact dermatitis, is initiated.…”
Section: Discussionmentioning
confidence: 99%
“…Human skin also functions as an active immune organ, constantly providing resistance to microorganisms and other noxious environmental agents through innate and acquired immune mechanisms. 1,2 To date, the intrinsic potential of the skin's immune cells has been underused.…”
Section: The Skin As An Immune Organmentioning
confidence: 99%
“…3,4 Under homeostatic conditions, keratinocytes constitutively produce Toll-like receptors, cytokines, and chemokines that initiate signaling cascades to maintain the diverse populations of leukocytes responsible for tolerance. 1 Immature antigen-presenting dendritic cells (DCs), including Langerhans cells (LCs) and classical DC subsets (cDC1 and cDC2) patrol the periphery, where they sample antigens and secrete cytokines that suppress inflammation and also promote survival of regulatory T (Treg) cells. [5][6][7] Skin-homing Treg cells also play a critical role in mitigating the reactivity of immune cells, promoting tolerance in the absence of a noxious signal.…”
Section: Maintenance Of Tolerance In Resting-state Skinmentioning
confidence: 99%
“…Ixekizumab is a humanized IgG4 monoclonal antibody that binds to IL‐17A and blocks the interaction with its receptor, IL‐17RA. IL‐17 plays a stimulatory role in the sensitization and effector stages, and has been reported to be elevated in patients with ACD caused by nickel and fragances . In addition, T helper 17 memory cell counts were higher in the peripheral blood of nickel‐allergic individuals than in control patients .…”
Section: Discussionmentioning
confidence: 98%