2017
DOI: 10.1590/abd1806-4841.20175496
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Abstract: BackgroundVenous ulcers represent 70% of the lower limb ulcers. They are difficult to heal, requiring a correct diagnostic and therapeutic approach. Many products have been developed to healing, such as homologous platelet gel obtained from the platelet concentrate exceeding from blood transfusion.ObjectiveTo evaluate the safety and efficacy of homologous platelet gel in venous ulcers compared with hydrocolloid dressing.MethodA pilot randomized clinical trial in patients with venous ulcers. Randomized groups (… Show more

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Cited by 18 publications
(31 citation statements)
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References 12 publications
(12 reference statements)
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“…We excluded another 29 articles for reasons like non‐RCTs, lack of useful outcome data, basic research, and introduction of a surgery technique. Finally, 19 RCTs were included in the meta‐analysis (Figure ).…”
Section: Resultsmentioning
confidence: 99%
See 2 more Smart Citations
“…We excluded another 29 articles for reasons like non‐RCTs, lack of useful outcome data, basic research, and introduction of a surgery technique. Finally, 19 RCTs were included in the meta‐analysis (Figure ).…”
Section: Resultsmentioning
confidence: 99%
“…As is shown in Figure , all studies involved random sequence generation. The methods of randomization were detailed in only 10 of the studies, in eight of which appropriate random sequence was generated; However, two used inappropriate randomization (one was randomized by date of birth, and the other was randomized by sealed envelope), which resulted in categorization as “high risk” (Figure ). Adequate allocation concealment was reported in eight of the studies .…”
Section: Resultsmentioning
confidence: 99%
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“…Our group's experience of advanced dressings and dermal substitutes over the years during treatment of patients with acute and chronic ulcers of multifactorial origin (arteriopathic, phlebopathic, immunological and traumatic) produced a study based on chronic arteriopathic patients, the results of which were published in the article "Wounds Difficult to Heal: An Effective Treatment Strategy" [60]. There we highlighted the fact that recognition of the aetiology of a skin lesion and the correction of the pathophysiological conditions that determine and support it are the assumption and "step" fundamental to the success of local treatment.…”
Section: Wound Healing -Current Perspectivesmentioning
confidence: 99%
“…It is not possible, in actual fact, to reach definitive conclusions given the variability of the factors capable of influencing the outcome of therapy and the difficulty of rendering populations of patients treated totally homogeneous. Furthermore, this aspect also emerges from the field's latest literature [60][61][62], being the only source available at present (since there are no definitive guidelines available). In addition, this kind of patient is not always willing to follow the lengthy periods of treatment often deemed necessary or comply with the temporal parameters the cure requires.…”
Section: Perspectives and Conclusionmentioning
confidence: 99%