Blue nevus with satellitosis: case report and literature review

Abstract

Blue nevus is a benign melanocytic lesion, typically asymptomatic and of unknown etiology. Many histological subtypes are recognized, the most commons being: common blue nevus, cellular blue nevus, and combined blue nevus. New rare variants have been described in the literature, with emphasis on eruptive blue nevus, plaque, agminate, linear, with satellitosis, disseminated, familial and targetoid. The diagnosis of blue nevus usually presents no difficulties, however, the presence of structures such as irregular edges or satellitosis, are highly suggestive of malignancy, and the differential diagnosis with malignant blue nevus and melanoma with peripheral spread should be considered. We report a case of blue nevus with satellitosis in a 15-year-old female patient.

Agminated blue nevi: a case series and updated dermoscopic review

“…Moreover, a rare variant of blue nevus with satellitosis, in which multiple blue globules located on the skin close to the main tumour are found, should be considered in the differential diagnosis of AGM [8].…”

Nevus Blue as a Sporadic Finding in a Patient with a Blue Toe?

“…Although in most cases blue nevi are considered benign, there are occasions when they are likely to progress to melanomas [ 3 ] [ 4 ] [ 5 ]. Determination of the risk of occurrence of a possible melanoma based on a blue nevus, as well as which of the occurred or congenital blue nevi will have an aggressive course, may be a significant challenge for the clinician [ 3 ] [ 4 ].…”

“…Several histological types of blue nevi are known: simple blue nevus, cellular blue nevus, atypical cellular blue nevus, combined blue nevus, blue nevus-like melanoma, and malignant blue nevus – with the worst prognosis [ 3 ] [ 4 ] [ 5 ].…”

“…No consensus has yet been reached on the histological features indicating malignancy in blue nevi, and this poses significant diagnostic difficulties in attempting to distinguish between benign and malignant blue nevus [ 7 ]. The presence of irregular edges with satellites (satellitosis) is considered a strong precondition for malignancy [ 5 ]. Other signs considered to be indicative of possible malignant transformation are infiltration boundaries, common mitoses, nuclear pleomorphism, hyperchromasia [ 7 ].…”

Case of a cellular blue nevus with multiple satellite lesions showing radial blue‐white lesion: Unique dermoscopy–histopathology correlation in blue nevus with satellitosis

“…Only eight cases of a blue nevus with satellite lesions have been reported between 1999 to 2015. 2 Histopathologically, three cases were common blue nevus, one case was cellular blue nevus, and the other four cases were not specified. [2][3][4] In these cases, patients' ages ranged 15-71 years, and the tumor size ranged 6-18 mm (average 9.5 mm).…”