2016
DOI: 10.1590/abd1806-4841.20163941
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Abstract: BACKGROUND:Actinic prurigo is an idiopathic photodermatosis, the pathophysiology of which has been hypothesized to involve subtype IV type b (Th2) hypersensitive response, whereby IL4, IL5, and IL13 are secreted and mediate the production of B cells, IgE, and IgG4.OBJECTIVES:To examine the association of serum IgE levels and the clinical severity of injuries.METHODS:This case-control study comprised patients with a clinical and histopathological diagnosis of actinic prurigo, as well as clinically healthy subje… Show more

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Cited by 11 publications
(4 citation statements)
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“…Ultraviolet light liberates TNF‐α from keratinocytes triggering the Th1 cell–mediated inflammatory pathway resulting in apoptosis, which forms the rationale for thalidomide therapy 4 . A recent study demonstrated elevated serum IgE levels in actinic prurigo that correlated with disease severity, as seen in atopic dermatitis, suggesting activation of the Th2 cell–mediated inflammatory pathway 5 . Dupilumab, an IL‐4 receptor antagonist, disrupts the Th2‐mediated inflammatory response.…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Ultraviolet light liberates TNF‐α from keratinocytes triggering the Th1 cell–mediated inflammatory pathway resulting in apoptosis, which forms the rationale for thalidomide therapy 4 . A recent study demonstrated elevated serum IgE levels in actinic prurigo that correlated with disease severity, as seen in atopic dermatitis, suggesting activation of the Th2 cell–mediated inflammatory pathway 5 . Dupilumab, an IL‐4 receptor antagonist, disrupts the Th2‐mediated inflammatory response.…”
Section: Discussionmentioning
confidence: 99%
“…4 A recent study demonstrated elevated serum IgE levels in actinic prurigo that correlated with disease severity, as seen in atopic dermatitis, suggesting activation of the Th2 cell-mediated inflammatory pathway. 5 Dupilumab, an IL-4 receptor antagonist, disrupts the Th2-mediated inflammatory response.…”
Section: A S Ementioning
confidence: 99%
“…The pathogenesis of AP is mediated by interleukin-2 (IL2); the presence of T lymphocytes in peripheral blood which are part of the Th1 response; tumor necrosis factor alpha (TNF-α); macrophages, and the induction of apoptosis as the last step in the type IV hypersensitivity reaction. 3 , 11 - 14 In addition, elements of the type IV hypersensitivity subtype b response have been observed in AP, such as elevated levels of serum IgE and the presence of mast cells, macrophages, and B lymphocytes. 13 - 15…”
Section: Introductionmentioning
confidence: 99%
“…A case–control study included 21 subjects diagnosed with AP (with mild, moderate, and severe injuries) and 21 clinically healthy subjects. Serum IgE was identified by immunoassay (access total IgE sandwich assay), concluding that patients with moderate to severe AP injuries had high IgE levels …”
mentioning
confidence: 99%