2016
DOI: 10.1590/abd1806-4841.20163722
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Abstract: Background:The incidence of cutaneous melanoma has increased over the last decades. Recurrences occur most frequently within the first 2-3 years after diagnosis but patients carry a lifelong risk of relapse. Nevertheless, there is no consensus in the literature on what screening tests patients should undergo.Objectives:To evaluate the most common melanoma metastasis sites among a South Brazilian population from a city with one of the highest melanoma rates, and establish the best screening method for these pat… Show more

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“…Forty-six full-text articles with the outcomes of interest (e.g., proportion and risk factors of MBM) were evaluated, and seven were excluded due to duplication or presenting results on the same population. A total of 39 articles were included in this SLR, and 38 full-text articles were extracted for the proportion results [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. Among of them, 29 studies included patients with MBM at diagnosis (Stage IV) ( Supplementary Table S1 ) and 9 studies reported MBM proportion with brain metastasis occurring after diagnosis ( Supplementary Table S2 ).…”
Section: Resultsmentioning
confidence: 99%
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“…Forty-six full-text articles with the outcomes of interest (e.g., proportion and risk factors of MBM) were evaluated, and seven were excluded due to duplication or presenting results on the same population. A total of 39 articles were included in this SLR, and 38 full-text articles were extracted for the proportion results [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 ]. Among of them, 29 studies included patients with MBM at diagnosis (Stage IV) ( Supplementary Table S1 ) and 9 studies reported MBM proportion with brain metastasis occurring after diagnosis ( Supplementary Table S2 ).…”
Section: Resultsmentioning
confidence: 99%
“…Among the 38 included studies for MBM proportion, 36 were observational studies and two were clinical trials. Five publications (2948 total patients) reported data on cutaneous melanoma separately, with a proportion of MBM at diagnosis of 33% [ 7 , 17 , 31 , 41 , 43 ], and 25% after diagnosis (for Stage IV patients) [ 26 , 43 ]. Fourteen publications included cutaneous mixed with others (with most patients having cutaneous), and the proportion was 23% at diagnosis ( n = 11 studies, 2875 total patients) [ 8 , 10 , 11 , 15 , 16 , 18 , 20 , 22 , 23 , 24 , 29 ] and 36% after diagnosis for stage IV patients ( n = 3 studies) [ 27 , 39 , 40 ] ( Table 1 ).…”
Section: Resultsmentioning
confidence: 99%
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