Characterization of sporotrichosis cases treated in a dermatologic teaching unit in the state of São Paulo - Brazil, 2003 - 2013

Marques, Gabriela Franco; Martins, Ana Luiza Grizzo Peres; Sousa, João; Brandão, Leticia Stella Gardini; Wachholz, Patrick Alexander; Masuda, Paula Yoshiko

doi:10.1590/abd1806-4841.20153447

Cited by 12 publications

(21 citation statements)

References 10 publications

(24 reference statements)

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“…[14][15][16] In the local context, the largest sporotrichosis case series have been reported in Southern and Southeastern Brazil, the main endemic areas of the disease. [17][18][19] There is little sporotrichosis-related information in the state of Espírito Santo, [20][21][22][23] also located within southeastern Brazil. In this way, our findings could be used in the state health surveillance program, for understanding and comparing the actual disease epidemiological changing pattern in the country.…”

Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Caus

Zanotti

Faccini-Martínez

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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This study discusses a historical patient series and is designed to describe clinical and epidemiological characteristics of human sporotrichosis in the state of Espírito Santo, Brazil. Data were derived from patients treated at the Infectious Diseases service of Cassiano Antônio Moraes University Hospital in Vitória, the state capital, from July 1982 to June 2012. A total of 171 patients were diagnosed with sporotrichosis, mostly men (80.7%) with a median age of 33 years and 5 months. We can presume an approximate average incidence rate of 4.9 cases per 100,000 inhabitants during the studied period. All the patients were involved in occupational or leisure activities with direct contact with soil or plants. Most cases were recorded in the mountainous region of the state during the hot and rainy periods. The average time elapsed from lesion progression to diagnosis was 3 months, with the lymphocutaneous form being the most common (70.2%), followed by the fixed cutaneous form (28.6%). Diagnosis was confirmed in 93.6% of the cases by culturing Sporothrix spp. in Sabouraud dextrose agar, and from the clinical features in the remaining cases. Aspiration of cutaneous nodule secretions was the best method for the collection of clinical specimens for disease diagnosis. A 25% saturated solution of potassium iodide (SSKI) was provided to almost all patients (98.8%), with therapeutic success. In conclusion, in this retrospective study in the state of Espírito Santo, we found that sporotrichosis affects primarily the ³ 10-year-old population, and the most common presentation is the lymphocutaneous form affecting the lower and upper limbs, and the infection appeared to be acquired predominantly through occupational activities. Treatment with SSKI was safe and effective.

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Section: Introductionmentioning

confidence: 99%

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Caus

Zanotti

Faccini-Martínez

et al. 2019

The American Journal of Tropical Medicine and Hygiene

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“…The primary lesion develops at the site of skin inoculation, commonly hands and arms. After some days to weeks it progresses to nodules along the lymphatic tract [2]. Patients are otherwise healthy, afebrile and well.…”

Section: Discussionmentioning

confidence: 99%

“…In a large outbreak that occurred in gold mines of South Africa in more than 3000 miners, none of them had disseminated disease. Pulmonary sporotrichosis via inhalation of Sporotrichum displays a form radiographically indistinguishable from tuberculosis and histoplasmosis in patients with severe underlying chronic obstructive pulmonary disease and alcoholism [2,3]. Granulomatous tenosynovitis and carpal tunnel syndrome have also been described [4].…”

Section: Discussionmentioning

confidence: 99%

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Cutaneous sporotrichosis as an occupational disease: Case report

Bimbi¹,

Brzezinski²

2017

Our Dermatol Online

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“…More than ten years after the publication of the results of Rosa et al (2005), in a recent study evaluating 25 patients with S. schenckii infection in the state of São Paulo conducted by Marques et al (2015), despite the small size of the sample, a high prevalence of the disease was also found in male individuals, mostly rural workers, who also had their upper limbs as the region most affected by the microorganism. This study differed from others (Oyarce et al, 2016;Rosa et al, 2005) because it emphasized sporotrichosis in its lymphocutaneous form as the most prevalent in the majority of individuals followed up.…”

Section: Introductionmentioning

confidence: 99%

Analysis of laser therapy effects in Sporothrix schenckii inactivation in vivo

Guirado

Feitosa

et al. 2018

Res. Biomed. Eng.

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Sporotrichosis is a common disease in tropical regions, caused by the fungus Sporothrix schenckii, affecting mainly rural workers and in direct contact with animals. Although treatment by indiscriminate use of oral antifungal drugs gives rise resistant isolates, leading to therapeutic failures and no remission of the disease. To evaluate the effectiveness of red low-power laser photobiomodulation in inactivation of S. schenckii infection induced in rodents. Methods: Subcutaneously inoculation (2x10 3 S. schenckii/ml, 0.2 ml suspension) in the left footpad, in 27 mice divided into: control (n = 6, inoculated, without irradiation): early stage (not inoculated) = 1 th biopsy; intermediate (9 weeks of evolution) = 2 nd biopsy; final (21 weeks of evolution) = 3 th biopsy. Treated (n = 21, inoculated and irradiated): early (13 weeks of evolution, 4 weeks after first irradiation) = 4 th biopsy, intermediate (17 weeks of evolution, 8 weeks after first irradiation) = 5 th biopsy, final (21 weeks of evolution, 12 weeks after first irradiation) = 6 th biopsy. Serial irradiation with biopsies occurred every 30 days during each month, for three months. At the end of testing, the mice were euthanized, and histological analyzes of biopsies were performed. Results: Each laser treatment session showed an inactivation of S. schenckii in treated animals compared to controls, with a regression of pseudoepitheliomatous hyperplasia, chronic inflammation, neutrophils, granulomas, giant mononuclear cells and steroid corpuscles. Conclusion: The laser photobiomodulation was effective on S. schenckii inactivation, appearing to be an interesting therapeutic option in infections caused by this organism.

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Characterization of sporotrichosis cases treated in a dermatologic teaching unit in the state of São Paulo - Brazil, 2003 - 2013

Cited by 12 publications

References 10 publications

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Epidemiological and Clinical Aspects of Sporotrichosis in Espírito Santo State, Southeast Brazil: A Study of Three Decades (1982–2012)

Cutaneous sporotrichosis as an occupational disease: Case report

Analysis of laser therapy effects in Sporothrix schenckii inactivation in vivo

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