Multiple minute digitate hyperkeratosis - a peculiar entity

Coutinho, Inês; Gameiro, Ana; Gouveia, Miguel; Cardoso, José Carlos; Figueiredo, Américo

doi:10.1590/abd1806-4841.20153440

Cited by 7 publications

(5 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Multiple minute digitate hyperkeratosis (MMDH) is a rare disorder of keratinization, first coined by Goldstein in 1967 . To our knowledge, only 27 female and 11 male cases of MMDH have been reported worldwide, with age at onset ranging from 4 months to 83 years, including this case . Several synonymous terms for MMDH exist in the medical literature (eg, familial disseminated piliform hyperkeratosis, disseminated spiked hyperkeratosis, minute aggregate keratosis) …”

Section: Discussionmentioning

confidence: 97%

“…1 To our knowledge, only 27 female and 11 male cases of MMDH have been reported worldwide, with age at onset ranging from 4 months to 83 years, including this case. 2,3 Several synonymous terms for MMDH exist in the medical literature (eg, familial disseminated piliform hyperkeratosis, disseminated spiked hyperkeratosis, minute aggregate keratosis). 4 Multiple minute digitate hyperkeratosis is characterized by multiple submillimeter spiky projections or spicules, usually located on the trunk and limbs in a symmetrical nonfollicular distribution, classically sparing the face and palmoplantar surfaces.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

A Case of Unilateral Focal Hyperkeratosis

2022

View full text Add to dashboard Cite

A patient in their 50s presented with asymptomatic keratotic papules, first noticed on the left middle and ring fingers and left toe web spaces more than 10 years earlier. The papules progressed proximally over the subsequent decade to involve the forearm, arm, scapular area, ankle, shin, and thigh, but only affected the left side of the body. The patient's face, palms, soles, and entire right side of the body were spared. The patient has a history of rosacea being treated with topical metronidazole gel for flares but was otherwise asymptomatic. The patient did not have any alopecia, night blindness, or dry eyes or skin. There was no history of any exposure to radiation or arsenic, nutritional deficiency, inflammatory skin disease, or malignant neoplasm. There was no family history of a similar condition.Examination revealed multiple, submillimeter, skin-colored to yellowish keratotic spiny projections over the aforementioned areas, only on the left side of the body (Figure , A and B). Punch biopsy from a lesion showed orthokeratosis with parakeratotic columns emerging from an epidermal invagination. The epidermis was mildly acanthotic and with a normal granular layer. There was a sparse superficial perivascular lymphocytic infiltrate. Adjacent hair follicles were unaffected (Figure , C). Diagnosis B. Multiple minute digitate hyperkeratosis

show abstract

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

A Case of Unilateral Focal Hyperkeratosis

2022

View full text Add to dashboard Cite

show abstract

“…6 18 19 MMDH, a rare keratinization disorder, is a morphologically similar entity that is differentiated by its nonfollicular nature, appreciated both clinically and histologically, and localization over the trunk and proximal extremities. 17 20 Sorafenib-induced KP-like eruption and PRP-like eruption are infrequently reported folliculocentric skin disease that demonstrates orthokeratotic follicular plug akin to SFH on histology. 21 22 23 24 However, the absence of erythematous inflammatory papules (of KP and PRP) and plaques (of PRP) in our patient rendered these diagnoses unlikely.…”

Section: Discussionmentioning

confidence: 99%

Sorafenib-Induced Spiny Follicular Hyperkeratosis: A Case Report with Review of Literature

Shajil

Sathishkumar

Boddu

et al. 2023

Indian J Med Paediatr Oncol

View full text Add to dashboard Cite

Sorafenib is a multikinase inhibitor used in the treatment of various solid tumors. Mucocutaneous adverse events are experienced by 70 to 90% of the patients receiving sorafenib, underscoring the importance of awareness among oncologists and dermatologists. Spiny follicular hyperkeratosis (SFH) is a benign and rarely reported skin reaction linked to sorafenib. It is characterized by flesh-colored or white, follicular hyperkeratotic spicules, preferentially involving the face, scalp, upper trunk, and upper arms. Besides being acknowledged as a paraneoplastic cutaneous manifestation of multiple myeloma, SFH has also been linked to a few diseases and drugs, other than sorafenib. However, the precise etiopathogenesis remains to be elucidated. We report an interesting case of SFH in a 14-year-old child, 1 week following the initiation of sorafenib. Trichodysplasia spinulosa, multiple minute digitate hyperkeratosis, keratosis pilaris, filiform warts, and pityriasis rubra pilaris are morphologically similar conditions that were excluded by clinicopathological correlation. A complete resolution of skin rash following sorafenib dose reduction further reinforced our diagnosis. Our patient also developed hand-foot skin reaction, facial erythema, and eruptive nevi during treatment. The regrowth of curly hair following chemotherapy-induced anagen effluvium was an interesting development in our case. We report this case to familiarize clinicians with this rare entity.

show abstract

“…Clinically, the spectrum of MMDH lesions has been largely characterized. Apart from the spiky filiform projections, the lesions could also be flat-topped, crateriform, 46,47 or adopt a dome-shape. Various colors have been described, 48 namely, brownish, white, yellowish, honey, greyish 49 or skin-colored.…”

Section: Clinical Featuresmentioning

confidence: 99%

Multiple minute digitate hyperkeratosis: 10 years from Caccetta's algorithm. A case report and narrative review

Prados‐Carmona,

Ruiz‐Villaverde

et al. 2023

J Deutsche Derma Gesell

View full text Add to dashboard Cite

SummaryTo date, the clinical appearance and histological features of multiple minute digitate hyperkeratosis have been well characterized. However, there is no consensus on its treatment. After a comprehensive search of the databases MEDLINE, EMBASE, Web of Science, and the Cochrane Library and Database of Systematic Reviews, we have summarized the available clinical evidence regarding the therapeutic approaches already reported for this entity since its first description in 1967. Additional publications were identified within the references of retrieved papers. Sixty‐five articles have been revised, resulting in a total of 73 compatible cases. The histopathological features and different classifications used through history have also been considered, updating and completing the available knowledge. Ultimately, we propose topical treatment with 5 % 5‐fluorouracil formulated with 10 % salicylic acid as a potential treatment that has been used successfully in a 51‐year‐old woman at our facility. Further research in form of prospective or comparative studies is encouraged for a better conceptualization of the therapeutics of this disease.

show abstract

Multiple minute digitate hyperkeratosis - a peculiar entity

Cited by 7 publications

References 9 publications

A Case of Unilateral Focal Hyperkeratosis

A Case of Unilateral Focal Hyperkeratosis

Sorafenib-Induced Spiny Follicular Hyperkeratosis: A Case Report with Review of Literature

Multiple minute digitate hyperkeratosis: 10 years from Caccetta's algorithm. A case report and narrative review

Contact Info

Product

Resources

About