Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent

Quaresma, Maria Victória; Filho, Fred Bernardes; Hezel, Janaína; Peretti, Murilo Calvo; Kac, Bernard Kawa; Azulay‐Abulafia, Luna

doi:10.1590/abd1806-4841.20153408

Cited by 12 publications

(3 citation statements)

References 8 publications

(8 reference statements)

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“…A study revealed that this drug was the most common cause of acquired methemoglobinemia, which is caused by hydroxylamine, a dapsone metabolite. 16 Although sulfamethoxazole-trimethoprim is not a drug of treatment for pemphigus vulgaris, this drug was prescribed to our patient because he presented infection in different body sites. Sulfamethoxazoletrimethoprim was prescribed due to its ability to control superinfections, mainly by Staphylococcus aureus, and also due to the indirect immunomodulatory effect, regulating the secretion of IL-1 and TNF-α.…”

Section: Discussionmentioning

confidence: 93%

Childhood pemphigus vulgaris is a challenging diagnosis

Filho¹,

Barbosa²,

Abreu

et al. 2021

Autops Case Rep

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Pemphigus Vulgaris (PV) is an uncommon autoimmune and blistering mucocutaneous disease. Childhood Pemphigus Vulgaris (CPV) is a pediatric variant of PV, which affects children below 12 years, being very rare among children under 10 years of age. CPV has similar clinical, histological, and immunological features as seen in PV in adults. The mucocutaneous clinical presentation is the most common in both age groups. Vesicles and erosions arising from the disease usually cause pain. A few CPV cases have been reported in the literature. This study reports a case of an 8-year-old male patient with oral lesions since the age of 3 years, and the diagnosis of pemphigus was achieved only 2 years after the appearance of the initial lesions. CPV remains a rare disease, making the diagnosis of this clinical case a challenge due to its age of onset and clinical features presented by the patient. Therefore, dentists and physicians should know how to differentiate CPV from other bullous autoimmune diseases more common in childhood.

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Section: Discussionmentioning

confidence: 93%

Childhood pemphigus vulgaris is a challenging diagnosis

Filho¹,

Barbosa²,

Abreu

et al. 2021

Autops Case Rep

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“…There are studies showing that dopsone treatment may have serious adverse effects. [13] Pemphigus is a bullous, rare and chronic autoimmune disease. There are two major forms of pemphigus: vulgaris and foliaceus.…”

Section: Discussionmentioning

confidence: 99%

Assessment of Biochemical Factors in Patients with Pemphigus Foliaceous Receiving Dapsone

2016

Eminent Association of Pioneers (EAP) August 22-24, 2016 Kuala Lumpur (Malaysia)

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Pemphigus is a rare group of blistering autoimmune diseases that affect the skin and mucous membranes. The reports indicate that Dapsone can be used as an effective medicine against this disease. This study was exerted to determine in in FBS, direct Billirubin and total Billirubin in patients with Pemphigus foliaceous receiving Dapsone. The data were analyzed using ANOVA. Our findings show that there was no significant difference in serum levels of FBS and total or direct Billirubin before and after receiving dapsone in patients with Pemphigus Foliaceous.

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“…Até o presente momento, não há consenso no manejo terapêutico de pacientes portadores de pênfigo, devendo ser consideradas as particularidades de cada caso. No entanto, corticosteroides sistêmicos são considerados a primeira linha de tratamento para reduzir a produção de autoanticorpos 7 , sendo a prednisona a droga mais utilizada. imunobiológico de alto custo e com possíveis complicações ainda não totalmente elucidadas 24,25 .…”

Section: 22unclassified

Pênfigos na amazônia: aspectos clínicos, epidemiológicos e terapêuticos de pacientes atendidos em serviço de referência.

Alves

Pires

Lima

et al. 2021

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O termo "pênfigo" é usado para descrever um grupo de doenças bolhosas autoimunes que comprometem a pele e as mucosas. É histologicamente caracterizado pela clivagem intraepidérmica e deposição de IgG na superfície dos ceratinócitos. Pênfigo vulgar (PV) e pênfigo foliáceo (PF) são as principais formas clínicas. Essa pesquisa objetivou identificar os aspectos clínicos, socio-demográficos e terapêuticos dos pacientes com diagnóstico de pênfigo. Para isso, foi realizada análise retrospectiva de prontuários médicos nos arquivos do ambulatório de Dermatologia da Universidade do Estado do Pará (UEPA) de janeiro de 2007 a janeiro de 2017. Foram identificados no período 19 pacientes com diagnóstico de pênfigo, dos quais 11 com PV e 8 PF, ambas as formas clínicas foram mais prevalentes em mulheres (57,89%). A faixa etária mais comprometida por PV foi entre 22 a 59 anos (81,82%), enquanto por PF maiores de 60 anos (62,5%). A principal área afetada nos casos de PV foi de membros superiores (20,69%), e de PF a face (21,43%). A prednisona foi o tratamento mais utilizado (42,87%). Observou-se que os dados epidemiológicos referentes a essa patologia ainda são escarços, especialmente na rgião norte do Brasil. Ainda não há consenso referente ao tratamento, e a escolha de medicações deve ser baseada nas particularidades de cada caso.

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Dapsone in the treatment of pemphigus vulgaris: adverse effects and its importance as a corticosteroid sparing agent

Cited by 12 publications

References 8 publications

Childhood pemphigus vulgaris is a challenging diagnosis

Childhood pemphigus vulgaris is a challenging diagnosis

Assessment of Biochemical Factors in Patients with Pemphigus Foliaceous Receiving Dapsone

Pênfigos na amazônia: aspectos clínicos, epidemiológicos e terapêuticos de pacientes atendidos em serviço de referência.

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