Syndrome In Question

Nascimento, Ana Cláudia Mendes do; Gaspardo, Daniela Barros Cortez; Cortez, Tatiana Mimura; Miot, Hélio Amante

doi:10.1590/abd1806-4841.20142615

Cited by 9 publications

(4 citation statements)

References 6 publications

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“…Including our case, there have been 16 reports of MAGIC syndrome (21 patients) in the English-language published work [ Table 1 ]. [ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 ] The patients (8 males and 13 females) had an age range of 10–59 years old (mean, 35.8; median, 37.0), which tends to occur at a young to early middle age. In ten evaluable cases, 6 were the white races and 4 were the yellow races.…”

Section: Discussionmentioning

confidence: 99%

“…In 20 evaluable cases, 16 and 4 showed initial symptoms of BD and RP, respectively, suggesting that the symptoms of BD may tend to predate the appearance of RP in the course of MAGIC syndrome. Pharmacological treatment options for MAGIC syndrome were comprised of nonsteroidal anti-inflammatory drugs,[ 1 14 ] dapsone,[ 1 2 13 ] colchicines,[ 1 8 9 10 11 15 ] steroids (prednisone, prednisolone, methylprednisolone, corticosteroid),[ 1 2 3 4 5 6 7 8 9 10 11 12 13 14 ] immunosuppressants (azathioprine, cyclophosphamide, methotrexate, cyclosporin A),[ 3 4 5 6 7 9 10 11 12 ] and biologics (infliximab, tocilizumab). [ 10 11 12 14 15 ] Although there is still no specific treatment for MAGIC syndrome, systemic steroids, immunosuppressants, and the combination therapy are considered the standard treatment for MAGIC syndrome.…”

Section: Discussionmentioning

confidence: 99%

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Mouth and genital ulcers with inflamed cartilage syndrome: Case report and review of the published work

et al. 2016

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Mouth and genital ulcers with inflamed cartilage (MAGIC) syndrome are disease that fulfilled criteria for diagnosis of Behcet's disease (BD) and relapsing polychondritis (RP). We report a 22-year-old Japanese woman presented with MAGIC syndrome and we described the clinicopathological characteristics of MAGIC syndrome based on a review of published cases from July 1985 to December 2015. In our case, the patient with oral aphthae, erythema nodosum, acne-like eruptions, uveitis, and polyarthritis fulfilled criteria for diagnosis of incomplete form of BD. The patient with uveitis, polyarthritis, and histological confirmation of chondritis also fulfilled criteria for diagnosis of RP. The patient was successfully treated with oral colchicine followed by prednisolone. The symptoms of MAGIC syndrome gradually disappeared, and the prednisolone dosage was gradually decreased and stopped. She has been in remission without active medication for a further 8 months. In the previous reports, some authors suggested that MAGIC syndrome was not a disease entity and might be RP occurring secondary to BD, another association of an autoimmune disease, or vasculitis with RP. However, the pathogenic association between MAGIC syndrome, BD, and RP is still unclear, and the number of reported cases of MAGIC syndrome is insufficient to establish a clear explanation. Therefore, further accumulation of data and careful observation of the clinical course are required to improve the understanding of MAGIC syndrome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Mouth and genital ulcers with inflamed cartilage syndrome: Case report and review of the published work

et al. 2016

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“…The MAGIC syndrome is the combination of m outh a nd g enital ulcers with i nflamed c artilage in Behçet's disease 2…”

Section: Examplesmentioning

confidence: 99%

When I use a word . . . . More medical magic

Aronson

2022

BMJ

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“…There have been cases cited of RP association with other autoimmune or inflammatory disease such as ulcerative colitis, ankylosing spondylitis, Behcet's disease, myelodysplastic syndromes [13,14,15,16]. There are reported cases of central nervous system affection translated by encephalitis, meningitis, meningoencephalitis [17,18].…”

Section: Discusionsmentioning

confidence: 99%

Relapsing Polychondritis Possibly Caused by Chronic Infection with Borrelia Burgdorferi – Case Report

Morariu

Badea

Cotoi

et al. 2015

Acta Medica Marisiensis

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Introduction: Relapsing polychondritis has been described by Rudolph von Jaksch Warthenhorst in 1923 under the name of polichondropathy. Although the etiology is unknown, an autoimmune mechanism is likely due to formation of autoantibodies to type II collagen in the extracellular matrix of the cartilage with its consequent destruction. Case report: We present a case with relapsing polychondritis according to McAdam and Damiani criteria and with positive Western blot reaction for Ac IgG anti Borrelia burgdorferi. Serological reaction became negative and the patient presented favorable evolution at 6 months follow-up after corticosteroid therapy and antibiotics. Conclusion: Chronic infection with Borrelia burgdorferi may play a role in relapsing polychondritis determinism

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Syndrome In Question

Cited by 9 publications

References 6 publications

Mouth and genital ulcers with inflamed cartilage syndrome: Case report and review of the published work

Mouth and genital ulcers with inflamed cartilage syndrome: Case report and review of the published work

When I use a word . . . . More medical magic

Relapsing Polychondritis Possibly Caused by Chronic Infection with Borrelia Burgdorferi – Case Report

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