Nanotechnology in Dermatology

Antônio, Joäo Roberto; Antônio, Carlos Roberto; Cardeal, Izabela Lídia Soares; Ballavenuto, Julia Maria Avelino; Oliveira, Joao Rodrigo

doi:10.1590/abd1806-4841.20142228

Cited by 73 publications

(41 citation statements)

References 125 publications

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“…There are three routes by which nanoparticles gain penetration: (1) intercellular, (2) transcellular, and (3) follicular permeation. Intercellular permeation is very difficult and depends on the solutes ability to penetrate the hydrophilic pores of the skin, whose size is estimated to be less than 36 nm [9]. Transcellular permeation is also highly unlikely given the tight matrix of corneocytes.…”

Section: Follicular Targeting With Nanoparticlesmentioning

confidence: 99%

Nanotechnology-Based Cosmetics for Hair Care

2015

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Abstract:Hair is a significant indicator of health and can have a major impact on an individual's cosmetic appearance. Research within the cosmetics industry has revealed that when nanomaterials are engineered into hair care, they can enhance the benefits of active ingredients in order to improve hair cosmesis. Within the cosmetics arena, the unique size and intrinsic properties of nanoparticles can be tailored to target the hair follicle and shaft. This review aims to provide an overview of cosmetic nanocarriers that can be employed to improve the appearance of hair.

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Section: Follicular Targeting With Nanoparticlesmentioning

confidence: 99%

Nanotechnology-Based Cosmetics for Hair Care

2015

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“…A drug must first be absorbed through the skin, cross the stratum corneum (horny layer) and subsequent layers of the epidermis and dermis to reach the blood flow and has its systemic action. However, the aim of cosmetic products is not to have a systemic action, but most of these formulations should have enough penetration to cross layers of epidermis [5,24]. There are three possible pathways for a solute to pass through the horny layer of intact skin [46][47][48].…”

Section: Skin Penetration Of Topical Formulationsmentioning

confidence: 99%

“…Various substances have been employed as antiseptics in nanoformulations like Chlorhexidine gluconate, naked TiO 2 , silver, etc. [5].Chlorhexidine gluconate employed as nano-formulation exhibits both immediate as well as sustained antibacterial effects. The former is due to fast absorption from the capsular wall while the latter is due to prolonged liberation of the antibacterial from the nucleus of the particle [74,75].…”

mentioning

confidence: 99%

“…Due to the alteration in the surface of the particle preventing their aggregation and enhancing their uptake by the cells [10]. Nanoparticle based diagnostic applications are presumed to be highly sensitive and specific; will require minimum quantity of tissue sample and will give results in a very short period of time [5]. The various possible nanoparticles employed in nanodiagnosis are Optical fabric, Gold nanoparticles, Quantum dots, nanoparticles with magnetic properties, etc [116,117].…”

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confidence: 99%

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Therapeutic and Diagnostic Applications of Nanotechnology in Dermatology and Cosmetics

Arif¹,

Nisa²,

Amin³

et al. 2015

J Nanomedine Biotherapeutic Discov

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Nanoscience is the branch of science pertaining to the study of minute particles on an atomic or molecular scale, whose size is measured in nanometers. A nanometer represents one billionth of a meter (i.e., 10 -9 m). Nanotechnology is an emerging branch of engineering that involves the use of particles on a nanoscale (1-100 nm). Thus, the application of nanotechnology in the field of dermatology is the Nanodermatology. Nanodermatology represents one of the most emerging fields for which an increasing interest is rising among scientists as well as pharmaceutical companies. Nanotechnology has revolutionized the treatment of several skin diseases. It is effective in targeted delivery of active medicaments and cosmetic ingredients. The skin forms the first point of contact for a diverse number of nanomaterials. Nanomedicine in dermatology has opened a new era in the diagnosis and treatment of various skin disorders. Possible applications of nanotechnology in dermatology and cosmetics include sunscreens, moisturizers, anti-aging formulations, phototherapy, anti-sepsis, vaccines, skin cancers, hair and nail care, etc. In this review after an introduction of nanotechnology, authors have described various types of nanoparticles followed by various possible indications of nanotechnology in dermatology and cosmetics. An account on safety of nanoparticles has also been added to the review. properties. Various other agents including vitamins (Vit. A, E, and K) and certain antioxidants like Carotenoids, lycopene, etc have been introduced in liposomes. These increase the physical and chemical stability of liposomes when dispersed in water [12]. Due to their biocompatible, biodegradable and nontoxic nature, liposomes find uses in a variety of cosmeceuticals as they encapsulate active moiety easily [11]. When associated to medication; liposomes ensure a high penetration into hair follicles [13]. Solid lipid nanoparticles (SLN)SLNs are colloidal carriers with size varying from 50 nm to 1000 nm. In these particles, Lipids (physiological lipids) are dispersed in an aqueous solution of surfactant or water [14]. SLNs possess various favourable properties viz., a) Presence of physiological and biodegradable lipids with low toxicity b) Occlusive properties which increase skin moisture level, c) Having a small size which ensures increased penetration of active ingredients, and d) Possessing characteristics of physical sunscreens of their own. These properties have made them popular in cosmetics [15,16]. SLNs have also been employed as topical vehicles for perfumes. When perfumes or fragrances are incorporated in SLNs, their release is delayed giving a prolonged effect of the perfume [17]. Nanostructured lipid carrier (NLC)NLC particles are manufactured by using blends of solid lipids with oils (liquid lipids).The solid lipid component is usually kept in a ratio of 70:30 while for oils, the preferred ratio is 99.9: 0.1. The overall melting point of such formulations decrease in comparison to the pure solid lipid which can be exp...

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“…They can also counteract the side effects of general photosensitivity, as they can specifically accumulate in target cells saving the surrounding healthy tissues from the undesired effects of PDT. 92 Preferential accumulation of nanoparticles in target tumour tissue also improves drug efficacy. With an identical dose, a higher concentration of photosenstiser is found in target cells when associated to nanoparticles than in isolated administration.…”

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confidence: 99%

Nanotechnology in Dermatology

Nasir¹,

Friedman²,

Wang³

2013

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Abstract:The scientific community and general public have been exposed to a series of achievements attributed to a new area of knowledge: Nanotechnology. Both abroad and in Brazil, funding agencies have launched programs aimed at encouraging this type of research. Indeed, for many who come into contact with this subject it will be clear the key role that chemical knowledge will play in the evolution of this subject. And even more, will see that it is a science in which the basic structure is formed by distilling different areas of inter-and multidisciplinary knowledge along the lines of new paradigms. In this article, we attempt to clarify the foundations of nanotechnology, and demonstrate their contribution to new advances in dermatology as well as medicine in general. Nanotechnology is clearly the future.

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Nanotechnology in Dermatology

Cited by 73 publications

References 125 publications

Nanotechnology-Based Cosmetics for Hair Care

Nanotechnology-Based Cosmetics for Hair Care

Therapeutic and Diagnostic Applications of Nanotechnology in Dermatology and Cosmetics

Nanotechnology in Dermatology

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