Lichen planus pigmentosus inversus

Lichen planus pigmentosus-inversus is a rare variant of lichen planus. So far, only 24 cases from 12 reports have been documented in the published work. The prominent characteristics of the disease are dark-brown macules and patches confined to the non-sun exposed, flexural areas and skin folds with lichenoid pathological changes and prominent melanin incontinence. We report three female Chinese patients with typical clinical and pathological manifestations and a miniature review of the published work.

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“…So far, LPP‐inversus has been reported in 24 cases from 12 reports internationally . The original seven cases were reported by Pock et al .…”

Section: Discussionmentioning

confidence: 99%

“…in the Czech Republic in 2001. As far as we know, there have been 24 cases reported internationally . Herein, we would like to present three more cases of this unusual entity with a review of the literature.…”

Section: Introductionmentioning

confidence: 99%

Lichen planus pigmentosus‐inversus: Report of three Chinese cases and review of the published work

Chen

Sun²,

Zhou

et al. 2014

The Journal of Dermatology

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“…It predominantly affects women, mostly after 40 years, but has been described in individuals 15–82 years of age. LPP‐inversus affects fair and dark skin, with a worldwide distribution . Its pathogenesis is similar to LPP, but in LPP‐inversus a transition from papular LP to macular lesions of LPP has been observed.…”

Section: Lichen Planus Pigmentosus Inversus (Lpp‐inversus)mentioning

confidence: 99%

“…Triggers (friction and wearing of tight clothing) must be avoided . Spontaneous resolution of lesions has been reported …”

Section: Lichen Planus Pigmentosus Inversus (Lpp‐inversus)mentioning

confidence: 99%

Lichen planus pigmentosus and its variants: review and update

Robles-Méndez¹,

Rizo-Frías²,

Herz‐Ruelas³

et al. 2017

Int J Dermatology

109

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Lichen planus pigmentosus (LPP) is considered a rare variant of lichen planus (LP). It is characterized by acquired dark brown to gray macular pigmentation located on sun-exposed areas of the face, neck, and flexures, commonly found in dark-skinned patients. In patients with LPP, an inflammatory lichenoid response results in marked pigmentary incontinence. It has been associated with hepatitis C virus, sun exposure, and contactants such as mustard oil and nickel. LPP-inversus affects fair and dark skin, predominantly involving flexural and intertriginous areas, while sun-exposed areas are spared; friction is an associated trigger. LPP along Blaschko's lines has been associated with susceptibility to genetic mosaicisms. LPP can present concomitantly with other variants of LP such as frontal fibrosing alopecia, as well as endocrinopathies, and autoimmune diseases. Treatment is difficult and consists of avoidance of triggers and topical and systemic medications in order to stop the inflammatory reaction and reduce pigmentation, improving aesthetic appearance and quality of life.

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“…Various morphological patterns of LPP including diffuse (most common), reticular, blotchy, perifollicular, 2 and atypical variants like inversus, 3 linear, 4 mucosal 5 and zosteriform 6 have been described. Herein, we report six unique cases of follicular LPP (FLPP), a previously undescribed morphological variant.…”

mentioning

confidence: 99%