2013
DOI: 10.1590/abd1806-4841.20132054
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Abstract: There are many alternatives to treat vitiligo, including surgical procedures, which are recommended for patients resistant to other therapies. The melanocyte/keratinocyte transplantation consists in the separation of epidermal cells obtained from a donor site and spreading these cells on the depigmented and dermabraded recipient area. Two patients were submitted to transplantation, showing more than 70% repigmentation in the treated areas after four months, both with excellent degree of satisfaction. The metho… Show more

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Cited by 11 publications
(9 citation statements)
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References 10 publications
(11 reference statements)
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“…Numerous studies have demonstrated the tolerability and efficacy in repigmentation of affected areas with MKTP in patients with refractory, stable vitiligo . However, the response rates have been largely variable, with 13–86% of patients achieving 95–100% repigmentation .…”
Section: Discussionmentioning
confidence: 99%
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“…Numerous studies have demonstrated the tolerability and efficacy in repigmentation of affected areas with MKTP in patients with refractory, stable vitiligo . However, the response rates have been largely variable, with 13–86% of patients achieving 95–100% repigmentation .…”
Section: Discussionmentioning
confidence: 99%
“…In 1992, the use of epidermal suspensions (containing melanocytes and keratinocytes) for repigmentation was introduced . The techniques were modified and presented by Olsson and Juhlin in 1998 and have been further refined by Mulekar and others to current autologous noncultured MKTP techniques as described in this review …”
Section: Introductionmentioning
confidence: 99%
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“…In recent years, various treatments such as immunosuppressive drugs, topical agents, and light-based and surgical therapies are increasingly applied to patients suffering from vitiligo for the restoration of damaged skin (4). Despite all progresses made in therapeutic approaches, several disadvantages, including high recurrence, inadequate pigment covering, and patient unsatisfactory, are reported (5). Significant advances in regenerative medicine and cell therapy have introduced melanocyte transplantation as a promising replacement for damaged cells (6).…”
Section: Introductionmentioning
confidence: 99%
“…Most skin substitutes are acellular; however, in the last few years increasing attention has been paid to the development of cellular substitutes mainly manufactured using two types of cells: fibroblasts and keratinocytes. [4][5][6] Moreover, recent researches also include new cell types such as melanocytes, 7 mesenchymal stem cells (MSCs), 8 epidermal stem cells, 9 hair follicle stem cells 10 and even cell-based products such as platelet-rich-plasma (PRP). [11][12][13] New approaches for skin TE are focused on combining novel natural or synthetic materials and living cells in several biomedical and pharmaceutical applications.…”
Section: Introductionmentioning
confidence: 99%