Argyria - Case report

Lencastre, André; Lobo, Maria de Lurdes; João, Alexandre

doi:10.1590/abd1806-4841.20131864

Cited by 15 publications

(23 citation statements)

References 10 publications

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“…4 It is noteworthy in mentioning, that the nitrates present in silver nitrate are toxic to human body and can cause blue and/or bluish-grey colored pigmentation, which is termed as argyria. 36 To find out nitrate content of AgNO 3 is completely reduced out by action of DMF and/or incubation in presence of silk fibroin during electrospinning. This will simultaneously address the degree of toxicity with the presented methodology.…”

Section: Resultsmentioning

confidence: 99%

“…It is also well established that silver enhances the epithelization . It is noteworthy in mentioning, that the nitrates present in silver nitrate are toxic to human body and can cause blue and/or bluish‐grey colored pigmentation, which is termed as argyria . To find out nitrate content of AgNO 3 is completely reduced out by action of DMF and/or incubation in presence of silk fibroin during electrospinning.…”

Section: Resultsmentioning

confidence: 99%

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Facile and highly efficient approach for the fabrication of multifunctional silk nanofibers containing hydroxyapatite and silver nanoparticles

Sheikh

Moon

et al. 2013

J Biomedical Materials Res

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In this study, a good combination consisting of electrospun silk fibroin nanofibers incorporated with high-purity hydroxyapatite (HAp) nanoparticles (NPs) and silver NPs is introduced as antimicrobial for tissue engineering applications. The variable pressure field emission scanning electron microscope results confirmed randomly placed nanofibers are produced with highly dispersed HAp and silver NPs in nanofibers after electrospinning. The X-ray diffraction results demonstrated crystalline features of each of the three components used for electrospinning. Moreover, the TEM-EDS analysis confirmed the presence and chemical nature of each component over individual silk nanofiber. The FT-IR analyses was used confirm the different vibration modes caused due to functional groups present in silk fibroin, Hap, and silver NPs. The obtained nanofibers were checked for antimicrobial activity by using two model organisms Escherichia coli and Staphylococcus aureus. Subsequently, the antimicrobial tests have indicated that prepared nanofibers do possess good bactericidal activity. The ability of N,N-dimethylformamide and silk fibroin used to reduce silver nitrate into silver metal was evaluated using MTT assay. The nanofibers were grown in presence of NIH 3T3 fibroblasts, which revealed toxic behavior to fibroblasts at higher concentrations of silver nitrate used in this study. Furthermore, cell attachment studies on nanofibers for 3 and 12 days of incubation time were minutely observed and correlated with the results of MTT assay. The reported results confirmed the high amounts of silver nitrate can lead to toxic effects on viability of fibroblasts and had bad effect in cell attachment.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Facile and highly efficient approach for the fabrication of multifunctional silk nanofibers containing hydroxyapatite and silver nanoparticles

Sheikh

Moon

et al. 2013

J Biomedical Materials Res

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“…This dependency is probably related to the stability of the complexes and the hydrophilicity-lipophilicity of the complexes formed by the type of the ligand [6,7,8]. It is noteworthy to mention that the nitrates present in silver nitrate are toxic to the human body and can cause blue and/or bluish grey pigmentation, which is known as argyria [9]. The goal of many studies was to find out whether the toxicity of AgNO 3 in complexes is reduced by the synergic action caused by the presence of metronidazole or 4-hydroxymethylpyridine molecules [1,5].…”

Section: Introductionmentioning

confidence: 99%

Silver(I) Complexes of the Pharmaceutical Agents Metronidazole and 4-Hydroxymethylpyridine: Comparison of Cytotoxic Profile for Potential Clinical Application

et al. 2019

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In previous papers, we have reported on the high antifungal and significant antibacterial activity against Gram-positive and Gram-negative bacteria of the water-soluble silver(I) complexes of metronidazole and derivatives of pyridine compared to silver nitrate. In the present study, the cytotoxic activity of the silver(I) complexes of metronidazole and 4-hydroxymethylpyridine was compared with that of silver nitrate. Metronidazole and 4-hydroxymethylpyridine were investigated using Balb/c 3T3 and HepG2 cell lines in order to evaluate the potential clinical application of silver(I) complexes. The cells were exposed for 72 h to compounds at eight concentrations. The cytotoxic concentrations (IC50) of the study compounds were assessed within four biochemical endpoints: mitochondrial activity, lysosomal activity, cellular membrane integrity, and total protein content. The investigated silver(I) complexes displayed comparable cytotoxicity to that of silver nitrate used in clinics. Mean cytotoxic concentrations calculated for investigated silver(I) complexes from concentration–response curves ranged from 2.13 to 26.5 µM. HepG2 cells were less sensitive to the tested complexes compared to fibroblasts (Balb/c 3T3). However, the most affected endpoint for HepG2 cells was cellular membrane damage. The cytotoxicity of both silver complexes was comparable for Balb/c 3T3 cells. The cytotoxic potential of the new silver(I) compounds compared to that of silver nitrate used in medicine indicates that they are safe and could be used in clinical practice. The presented results are yet more stimulating to further studies that evaluate the therapeutic use of silver complexes.

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“…The reason as to why the gray color is more evident in photoexposed skin areas is unknown. It is believed that silver assumes a brownish-black hue through a chemical reduction reaction or through a photomediated exacerbation of its stimulatory effect on melanin synthesis [3].…”

Section: Discussionmentioning

confidence: 99%

Localized cutaneous argyria: a new observation

Kadiri¹,

Baybay²

2021

Our Dermatol Online

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A 27-year-old female, a radiotherapy technician, was referred to our consultation with a localized gray pigmentation of the perinasal area. The condition had been asymptomatic for its entire duration of 2 years. A dermatological examination found a localized bluish-gray pigmentation in the perinasal area. Dermoscopy revealed an annular bluish-gray patch. Her occupation involved the manufacture and micromanipulation of machines, which required handling pure iron, nickel, copper, and silver with bare hands. She also reported a tic of flaring the nose. A skin biopsy was performed and histology revealed deposits of fine granules in the basal cell layer of eccrine sweat glands and along the elastic fibers of the superficial dermis, conforming with the diagnosis of argyria. The patient was given laser Q-switching treatment and showed a measurable improvement. This case studies a currently rare dermatological curiosity. Argyria is a disease caused by chronic absorption of silver-rich materials. This is the first description of argyria following the manipulation of radiopaque caches with a tic of flaring the nose.

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Argyria - Case report

Cited by 15 publications

References 10 publications

Facile and highly efficient approach for the fabrication of multifunctional silk nanofibers containing hydroxyapatite and silver nanoparticles

Facile and highly efficient approach for the fabrication of multifunctional silk nanofibers containing hydroxyapatite and silver nanoparticles

Silver(I) Complexes of the Pharmaceutical Agents Metronidazole and 4-Hydroxymethylpyridine: Comparison of Cytotoxic Profile for Potential Clinical Application

Localized cutaneous argyria: a new observation

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