Modificações na angulação coronária após implante de suporte vascular bioabsorvível e de stents de cromo-cobalto e aço inoxidável

Silva, Mateus Veloso e; Costa, J. Ribamar; Abizaid, Alexandre; Staico, Rodolfo; Taiguara, Danillo; Borghi, Tarcísio Campostrini; Costa, Ricardo; Chamié, Daniel; Sousa, Amanda G. M. R.; Sousa, J. Eduardo

doi:10.1590/s2179-83972013000400006

Cited by 1 publication

(1 citation statement)

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“…Stent conformity is described as the flexibility of a stent in its expanded state with adaptation to the natural shape of the vessel, determining the flow rheology change within the vessel [49] . The stent design and its material are two main factors determining stent conformity [50] . Previous studies showed that open-cell design had better stent conformity than closed-cell design [51,52] .…”

Section: Bio-adaptation Between Mg Stent and Local Microenvironmentmentioning

confidence: 99%

Bio-Adaption between Magnesium Alloy Stent and the Blood Vessel: A Review

Zhao

Betts

et al. 2016

Journal of Materials Science & Technology

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Biodegradable magnesium (Mg) alloy stents are the most promising next generation of bio-absorbable stents. In this article, we summarized the progresses on the in vitro studies, animal testing and clinical trials of biodegradable Mg alloy stents in the past decades. These exciting findings led us to propose the importance of the concept “bio-adaption” between the Mg alloy stent and the local tissue microenvironment after implantation. The healing responses of stented blood vessel can be generally described in three overlapping phases: inflammation, granulation and remodeling. The ideal bio-adaption of the Mg alloy stent, once implanted into the blood vessel, needs to be a reasonable function of the time and the space/dimension. First, a very slow degeneration of mechanical support is expected in the initial four months in order to provide sufficient mechanical support to the injured vessels. Although it is still arguable whether full mechanical support in stented lesions is mandatory during the first four months after implantation, it would certainly be a safety design parameter and a benchmark for regulatory evaluations based on the fact that there is insufficient human in vivo data available, especially the vessel wall mechanical properties during the healing/remodeling phase. Second, once the Mg alloy stent being degraded, the void space will be filled by the regenerated blood vessel tissues. The degradation of the Mg alloy stent should be 100% completed with no residues, and the degradation products (e.g., ions and hydrogen) will be helpful for the tissue reconstruction of the blood vessel. Toward this target, some future research perspectives are also discussed.

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Section: Bio-adaptation Between Mg Stent and Local Microenvironmentmentioning

confidence: 99%