Avaliação histopatológica de trombos coronários em pacientes com infarto agudo do miocárdio e elevação do segmento ST

Abstract

background: Primary percutaneous coronary intervention (PCI) is the preferred reperfusion method in patients with ST segment elevation myocardial infarction (STEMI). Manual aspiration thrombectomy has been increasingly used and enables the analysis of thrombus aspirates. Methods: Consecutive patients undergoing primary PCI were enrolled from December of 2009 to June of 2011. Clinical, laboratory, and angiographic data were prospectively collected and entered into a dedicated database. The decision to perform thrombus aspiration was left to the discretion of the surgeons. One hundred and twelve samples of thrombi were collected, stored in 10% formalin fixed paraffin, stained with hematoxylineosin, and analysed by light microscopy. Upon histopathological evaluation, the thrombi were classified as recent thrombi or lysed/organised thrombi. results: Recent thrombi were identified in 68 patients (61%), and lysed/organised thrombi were found in 44 patients (39%). Patients with recent thrombi had higher red blood cell infiltration (P = 0.03). There were no other statistically significant differences regarding clinical, angiographic, laboratory, or clinical outcomes between the two study groups. Conclusions: In patients with STEMI undergoing primary PCI, two-thirds of thrombus aspirates presented the histopathological features of recent thrombi. There were no significant associations among these characteristics and the clinical, laboratory, and angiographic data in this

A “Ping-Pong” left atrial thrombus mimicking left atrial myxoma: A case report

“…In contrast, the thrombus found erythrocytes, leukocytes, and fibrin ( Fig. 4 B) [ 12 ]. Echocardiography of the patient, in this case, revealed a freely moving ping-pong-like thrombus in the LA.…”

Immunohistochemical Characteristics of Coronary Thrombi in Patients with ST-Elevation Myocardial Infarction and Diabetes Mellitus: Pilot Studyy

“…4 Primary percutaneous coronary intervention (PPCI) is considered the preferred method of reperfusion in AMI. [7][8][9] Variables, such as red color and thrombus chronology, have been associated with increased mortality, 10,11 but the physiopathological role of the different elements that constitute the thrombus has been seldom studied. 6 Additionally, thrombus removal has allowed for a new line of research regarding the analysis of the morphology, histology, and factors associated with different types of thrombi.…”