volume 50, issue 3, P583-590 2014
DOI: 10.1590/s1984-82502014000300018
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Abstract: The present study was planned to improve the stability of dithranol using solid dispersions (SD). Two different SD at a 1:9 ratio of dithranol/excipient were prepared: one of them using glyceryl behenate as excipient and the other using a mixture of argan oil with stearic acid (1:8 ratio) as excipient. Pure dithranol and SD of dithranol were incorporated in an oil-in-water cream and in a hydrophobic ointment in a drug/ dermatological base ratio of 1:10. The physical and mechanical properties of semisolid form…

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