Use of solid dispersions to increase stability of dithranol in topical formulations

Estanqueiro, Marilene; Conceição, Jaime; Amaral, Maria Helena; Lobo, José Manuel Sousa

doi:10.1590/s1984-82502014000300018

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…Assim, o probe fêmea, contendo a formulação, foi colocado no suporte da base, sendo este alinhado com o cone macho, que contém a sonda de análise. As análises foram efetuadas em triplicata por teste de penetração, através da determinação do parâmetro "Work of Shear" com distância percorrida de 25 mm, numa velocidade de 20 mm/s utilizando cone acrílico em analisador de textura TA.XTplus (Stable Micro Systems) 6,7 . such as hardness, consistency, viscosity index, among others.…”

Section: Análise De Espalhabilidadeunclassified

“…Thus assembled, the female probe containing the formulation was placed on the base support, which is aligned with the male cone containing the analysis probe. The samples were analysed in triplicate by a penetration test, by determining the parameter "Work of Shear" with distance of 25 mm at a speed of 20 mm / sec using an acrylic cone 6,7 .…”

Section: Spreadability Analysismentioning

confidence: 99%

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Hair care formulations containing argan oil: development, stability and texture profile

Delsin

Campos

2015

BBR

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Biopharmaceutical Sciences│Ciências BiofarmacêuticasBiomed Biopharm Res. , 2015; (12) 2: , 233-242 233 Biomedical and Biopharmaceutical Research J o r n a l d e I n v e s t i g a ç ã o B i o m é d i c a e B i o f a r m a c ê u t i c aHair care formulations containing argan oil: development, stability and texture profile AbstractThe aim of this study was to develop hair care cosmetic formulations containing argan oil to evaluate the stability and texture profile of these formulations. Shampoos, conditioners and leave-in formulations were developed with or without (vehicle) argan oil in concentrations of 0.1, 2.0 and 2.0% (w/w) respectively. The formulations were stored at room temperature (25°C), 37°C and 45°C for a period of 28 days and submitted to spreadability and texture tests using the Texture Analyser. For this purpose, work of shear and consistency parameters were determined. The results have shown that all formulations were stable and the argan oil-based formulations had a better spreadability when compared with the vehicle. This is a desirable effect, once cosmetic formulations which presents a lower values of work of shear are better accepted by cosmetic sensory panels. In addition, no difference was found between conditioners with or without argan oil in terms of texture profile, and leave-informulation with argan oil showed an increased consistency when compared with the vehicle. Finally, formulations with argan oil showed better the texture profile, therefore, it is a potential ingredient for use in hair care formulations.Keywords: Argan Oil, hair care formulations; Stability, Texture profile ResumoO objetivo deste estudo foi desenvolver e avaliar a estabilidade e textura de formulações cosméticas para os cuidados dos cabelos contendo óleo de argan. Formulações de shampoos, condicionadores e leave on foram desenvolvidas com ou sem (veículo) óleo de argan nas concentrações de 0,1, 2,0 e 2,0% (a/a), respectivamente. As formulações foram armazenadas à temperatura ambiente (25°C), 37°C e 45°C, por 28 dias e submetidas à testes de espalhabilidade e de textura utilizando um texturômetro. Foram avaliados os parâmetros de "Work of Shear" e consistência. Os resultados mostraram que as formulações foram estáveis e as formulações com óleo de argan mostraram melhor espalhabilidade quando comparada com o veículo. Este é um efeito desejável pois formulações cosméticas que apresentam baixos valores de "Work of Shear" são mais bem aceitas por painéis sensoriais. Além disso, não houve diferença entre os condicionadores, com ou sem óleo de argan, em termos de perfil de textura e a formulação leave on contendo óleo de argan mostrou um aumento da consistência em relação ao o veículo. Por fim, as formulações contendo o óleo de argan mostraram um melhor perfil de textura, e portanto, este é um potencial ingrediente para utilização em formulações para os cuidados dos cabelos.Palavras-chave: Óleo de Argan, Formulações para os cuidados dos cabelos; Estabilidade, Perfil de textura

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Section: Análise De Espalhabilidadeunclassified

Section: Spreadability Analysismentioning

confidence: 99%

Hair care formulations containing argan oil: development, stability and texture profile

Delsin

Campos

2015

BBR

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“…Considerable data have been provided in the literature that DTL impedes cellular proliferation in psoriatic skin, by limiting cellular movement or restricting the run of neutrophils, and so, it exhibits an anti-inflammatory action [15]. Despite being effective, benefits of this moiety are hampered by burning, staining, irritating and necrotizing expressions on normal and diseased skin [16]. Further, it also exhibits challenges in the preparation of nanoformulations, which have been attributed to its higher lipophilicity and sensitivity toward photodegradation, as it easily gets photo-oxidized [17].…”

Section: Introductionmentioning

confidence: 99%

“…DTL oxidation increases in daylight and it is vulnerable to air, ultraviolet light and higher temperature [18]. The degradation by-products, such as dithranol dimmer and danthron, are anticipated to give unwanted results and found less active or inactive [16,19]. The currently available commercial formulations are not only unsuccessful to diminish the unwanted effects of DTL but also not able to enhance its photochemical stability [20].…”

Section: Introductionmentioning

confidence: 99%

“…The currently available commercial formulations are not only unsuccessful to diminish the unwanted effects of DTL but also not able to enhance its photochemical stability [20]. As per literature reports, several endeavors have been attempted to synthesize novel DTL formulations to improve its solubility and stability such as liposomes/niosomes [20], hydrophilic silica aerogels [21], solid lipid nanoparticles [22], phospholipid microemulsions [17], nanoemulsions [23], hyperbranched dendritic nanocarriers [24], solid lipid dispersions [16], solid lipid nanoparticles [22], lipid-core nanocapsules [25] and dendrimer entrapped microsponges gels [26]. Although each reported novel system have addressed a few concerns of DTL, there are certain inherent limitations associated with each carrier.…”

Section: Introductionmentioning

confidence: 99%

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Comparative evaluation of dithranol-loaded nanosponges fabricated by solvent evaporation technique and melt method

et al. 2023

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Background Dithranol, a standard drug for psoriasis, has lured keen attention by virtue of its antioxidant, anti-proliferative and anti-inflammatory activities. However, its poor stability and solubility critically impair the formulation design, evaluation and administration. To improve these issues, dithranol was encased in β-cyclodextrin nanosponges using solvent evaporation technique. Previously, nanosponges containing dithranol were developed in our laboratory using melt technique. Herein, a comparison of nanosponges prepared by both techniques was also included. Results Different nanosponge batches were engineered using diphenyl carbonate as cross-linker with β-cyclodextrin as polymer employing solvent evaporation technique. Dithranol was loaded in nanosponges via lyophilization. Fourier transform infrared spectroscopy, differential scanning colorimeter and powdered X-ray diffraction studies confirmed successful encapsulation and complexation of this drug in β-cyclodextrin nanosponges. The effect of a variable amount of cross-linker on the solubility, encapsulation efficiency, zeta potential, particle size and polydispersity index was evaluated in fabricated nanocarriers. Further, β-cyclodextrin nanosponge batches were subjected to solubility studies, photostability examination and antioxidant activity analysis and compared with previously prepared dithranol-loaded nanosponges. From the present studies results, it was concluded that dithranol-loaded nanosponges using solvent evaporation technique not only improved solubility and photostability but also preserved the antioxidant efficacy of the chosen drug. Conclusion The overall results emphasized moral guidance concerning encapsulation, evaluation and characterization and accredited dithranol solubilization, photostability and antioxidant potential. However, solvent evaporation and melt method are easy and promising methods to fabricate nanosponges for dithranol. This comparative study demonstrated the parameters which were affected by chosen techniques. Further, from the results of present studies, it was concluded that the formulation scientists should select the preparation technique based on the objective of their research work and requirement of desired features. Graphical abstract

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Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst.

Feilcke

Arnouk

Raphane

et al. 2019

Journal of Pharmaceutical and Biomedical Analysis

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Use of solid dispersions to increase stability of dithranol in topical formulations

Cited by 5 publications

References 30 publications

Hair care formulations containing argan oil: development, stability and texture profile

Hair care formulations containing argan oil: development, stability and texture profile

Comparative evaluation of dithranol-loaded nanosponges fabricated by solvent evaporation technique and melt method

Biological activity and stability analyses of knipholone anthrone, a phenyl anthraquinone derivative isolated from Kniphofia foliosa Hochst.

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