2014
DOI: 10.1590/s1984-82502014000200012
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Abstract: The dissolution process is considered an important in vitro tool to evaluate product quality and drug release behavior. Single dissolution methods for the analysis of combined dosage forms are preferred to simplify quality control testing. The objective of the present work was to develop and validate a single dissolution test for a telmisartan (TEL) and amlodipine besylate (AML) combined tablet dosage form. The sink conditions, stability and specificity of both drugs in different dissolution media were tested … Show more

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Cited by 2 publications
(1 citation statement)
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“…Derivative spectrofluorimetry is a powerful approach for the resolution of analytes when an analytical peak is overlapped by a large peak of another analyte, particularly in multi-component analysis. [13][14][15][16][17][18][19][20][21] The development of a suitable method for simultaneous analysis of TMH and SFS is a challenge because the drugs are present in the ratio of 1:15 in tablet form. If SFS is diluted, the quantification of second drug (TMH) analysis may become difficult.…”
Section: Tamsulosin Hydrochloride (Tmh) Is Chemically 5-[(2r)-2-{[2-(mentioning
confidence: 99%
“…Derivative spectrofluorimetry is a powerful approach for the resolution of analytes when an analytical peak is overlapped by a large peak of another analyte, particularly in multi-component analysis. [13][14][15][16][17][18][19][20][21] The development of a suitable method for simultaneous analysis of TMH and SFS is a challenge because the drugs are present in the ratio of 1:15 in tablet form. If SFS is diluted, the quantification of second drug (TMH) analysis may become difficult.…”
Section: Tamsulosin Hydrochloride (Tmh) Is Chemically 5-[(2r)-2-{[2-(mentioning
confidence: 99%