Management of effluents and waste from pharmaceutical industry in Minas Gerais, Brazil

Deschamps, Eleonora; Vasconcelos, Olivia; Lange, Liséte Celina; Donnici, Cláudio Luis; Silva, Mercês Coelho da; Sales, J.A. de

doi:10.1590/s1984-82502012000400017

Cited by 17 publications

(5 citation statements)

References 13 publications

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“…Na indústria farmacêutica, possui um grande potencial poluidor, seja pela ausência ou ineficiência de tratamento de efluentes, podendo desta forma destinar substâncias químicas ao meio ambiente. Estudos realizados no Brasil, Estados Unidos e Europa trazem à tona a detecção de fármacos na faixa de μg L -1 e ng L -1 , em águas residuais municipais, águas superficiais, subterrâneas e em menor medida em água potável (Deschamps et al, 2012;Borrelly et al, 2012;Cunha et al, 2016).…”

Section: Rota De Contaminaçãounclassified

Contaminação de efluentes por amoxicilina: consequências ambientais e métodos de remoção

2022

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A intensificação na poluição gerada pelas atividades humanas por décadas, lançando efluentes, in natura ou parcialmente tratados nos corpos hídricos receptores, causando sérios danos ao meio ambiente. Dentre estes efluentes, os fármacos acabam trazendo uma grande preocupação, uma vez que, podem ser resistentes inclusive aos processos convencionais de tratamento, o que acaba alertando para a problemática da falta de tratamento adequado. Objetivou-se com este trabalho, realizar uma análise dos métodos de tratamento de efluentes utilizados para remoção e degradação do antibiótico do grupo β-lactâmicos, amoxicilina. Foi realizado um levantamento bibliográfico envolta de trinta e oito artigos, com uma filtragem e seleção, resultando em apenas doze trabalhos que se enquadraram nos pré-requisitos estabelecidos. Grande parte dos estudos selecionados desenvolveu suas análises em efluentes contaminados artificialmente, utilizando técnicas de adsorção, processos oxidativos avançados (POAs), wetlands, biorreator com membranas submersas, filtro de carvão ativado e hidrólise. É importante ressaltar que cada estudo, operou com técnicas bastante particulares, sendo este o principal motivo dos diferentes resultados encontrados em métodos bastante semelhantes. A análise demonstrou que dentre os métodos observados, apenas o processo tradicional de oxidação com reagente Fenton, e o método de remoção por Hidrólise Alcalina, com pH de 12,5 em 60 minutos atingiram a excelência de 100% da remoção do antibiótico. No outro extremo observou-se que a técnica de remoção do antibiótico por meio de wetlands construídos, atingiu a remoção mínima de 15% e o POA com fotólise natural em tempo de 360 minutos com remoção de 24%. Os números encontrados apontam a importância de combinar os métodos de tratamento de esgoto para alcançar uma maior pureza do efluente que será lançado no ambiente.

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Section: Rota De Contaminaçãounclassified

Contaminação de efluentes por amoxicilina: consequências ambientais e métodos de remoção

2022

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“…Fig. 1 The interconnection between the Pharmaceutical industry, environment, humans and animals Studies have confirmed antibiotic residues in effluents, municipal wastewaters, surface waters, and groundwater around the pharmaceutical manufacturing sites (Deschamps et al 2012;Tong et al 2020). A few studies showing presence of huge quantities of antibiotics in surface water, drinking water, pharmaceutical effluent and in the effluent of wastewater treatment plant is presented in Table 1.…”

Section: Pharmaceutical Industry Effluent Contributions To Amr In the Environmentmentioning

confidence: 99%

Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance

Kotwani

Joshi

Kaloni

2021

Environ Sci Pollut Res

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Antimicrobial resistance (AMR) is a complex global health issue and will push twenty-four million people into extreme poverty by 2030, risking the sustainable development goals (SDGs) 2, 3, 6, 9, 12, and 17 if not addressed immediately. Humans, animals, and the environment are the reservoirs that contribute and allow AMR to propagate in interconnected ecosystems. The emergence of antibiotic-resistant bacteria and antibiotic-resistant genes in the water environment has become an important environmental health issue. One of the major influencers from environment sector is the pharmaceutical industry which is growing globally to meet the ever-increasing demand of antibiotics, especially in low-and middle-income countries. The pharmaceutical effluent has a mix of large concentrations of antibiotics and antibiotic resistance genes, and these sites act as hotspots for environmental contamination and the spread of AMR. Inadequate treatment of the effluent and its irresponsible disposal leads to unprecedented antibiotic contamination in the environment and their persistent presence in the environment significantly modulates the bacterial genomes' expression that is responsible for increase and spread of AMR. However, not much interventions are suggested in the National Action Plan developed on AMR by many countries. There are no regulations across the globe till date for the level of antibiotic residues in pharmaceutical effluent for the growing pharmaceutical industry. This review put together the work done showing several detrimental effects of the antimicrobial residues in the pharmaceutical effluent which leads to rise in development of AMR. The environment risk approach and need to have indicators to measure environment risk is a way forward for all countries engage in antibiotic manufacturing. Overall, efforts to address the problem are isolated and fragmented. Policymakers, regulators, manufacturers, researchers, civil society, and the community need to collaborate so that antibiotics are produced sustainably and continue to stay effective in treating bacterial infections.

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“…Liquid chromatography is the technical method and powerful tool to determine the traces of amoxicillin present in the environment. This is the major pollutant and pharmaceutical wastes put into the environment [7] . Chemotheraphy Waste: Bulk chemotherapy wastes are let into the environment which is considered as the most hazardous materials.…”

Section: Aquatic Pollutionmentioning

confidence: 99%

Endangerment of Pharmaceutical Waste Disposal in the Environment

2020

MLU

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Disposal of pharmaceutical wastes in the environment leads to many losses and causes damage to the ecosystem. Plants, animals and human beings are put in endangerment due to the medicines and injections disposed in the environment. Toxic chemicals and substances exposed to the public nearby places causes many diseases such as respiratory syndromes and cancers skin infections and genetic disorders. Disposal in marine area pollutes the living atmosphere of aquatic organisms affects the ecosystem in unexpected ways. Considering this, environmental department should take effective precautions to protect and ensure the safety and peaceful living of beings in the environment. In this the article pollutants, toxic chemicals scavenged in the environment by the pharmaceutical industry, which has many adverse effects to the safety and a clean environment are discussed.

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Management of effluents and waste from pharmaceutical industry in Minas Gerais, Brazil

Cited by 17 publications

References 13 publications

Contaminação de efluentes por amoxicilina: consequências ambientais e métodos de remoção

Contaminação de efluentes por amoxicilina: consequências ambientais e métodos de remoção

Pharmaceutical effluent: a critical link in the interconnected ecosystem promoting antimicrobial resistance

Endangerment of Pharmaceutical Waste Disposal in the Environment

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