Antidepressant and skeletal muscle relaxant effects of the aqueous extract of the Prosopis cineraria

George, Mathew; Joseph, Lincy; Sharma, Abishika

doi:10.1590/s1984-82502012000300025

Cited by 16 publications

(14 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Muscle relaxant activity was analyzed using rotarod apparatus and total fall off-time for standard and control group was measured. A significant decrease in immobility time duration in FST was observed (at a dose of 200 mg/kg of leaf extract), and the effect was similar to imipramine [81].…”

Section: Anti-depressive and Cns Disorders Effectsmentioning

confidence: 57%

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

et al. 2019

View full text Add to dashboard Cite

Members of the Prosopis genus are native to America, Africa and Asia, and have long been used in traditional medicine. The Prosopis species most commonly used for medicinal purposes are P. africana, P. alba, P. cineraria, P. farcta, P. glandulosa, P. juliflora, P. nigra, P. ruscifolia and P. spicigera, which are highly effective in asthma, birth/postpartum pains, callouses, conjunctivitis, diabetes, diarrhea, expectorant, fever, flu, lactation, liver infection, malaria, otitis, pains, pediculosis, rheumatism, scabies, skin inflammations, spasm, stomach ache, bladder and pancreas stone removal. Flour, syrup, and beverages from Prosopis pods have also been potentially used for foods and food supplement formulation in many regions of the world. In addition, various in vitro and in vivo studies have revealed interesting antiplasmodial, antipyretic, anti-inflammatory, antimicrobial, anticancer, antidiabetic and wound healing effects. The phytochemical composition of Prosopis plants, namely their content of C-glycosyl flavones (such as schaftoside, isoschaftoside, vicenin II, vitexin and isovitexin) has been increasingly correlated with the observed biological effects. Thus, given the literature reports, Prosopis plants have positive impact on the human diet and general health. In this sense, the present review provides an in-depth overview of the literature data regarding Prosopis plants’ chemical composition, pharmacological and food applications, covering from pre-clinical data to upcoming clinical studies.

show abstract

Section: Anti-depressive and Cns Disorders Effectsmentioning

confidence: 57%

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

et al. 2019

View full text Add to dashboard Cite

show abstract

“…NC: Negative Control FLX: Fluoxetine 20 mg/kg TEP 50: Alpha-Terpineol 50 mg/kg TEP100: Alpha-Terpineol 100 mg/kg Thus, preclinical experimental studies using mice and behavioral testing protocols are of paramount importance to assess the effectiveness of substances with potential antidepressants. In one of these trials, there was a reduction in the immobility time of mice in FST, when they received Proposis cineria at a dose of 200 mg/kg compared to the control group, demonstrating significant antidepressant activity and relaxation of skeletal muscle (George, Joseph, & Sharma, 2012). The same effect was verified by Mendonça-Netto et al (2008) when using a fraction of total tertiary alkaloids 12 mg/kg of Cissampelos sympodialis Eichler (Menispermaceae).…”

Section: Subtitlementioning

confidence: 76%

“…The adapted test by Gonçalves et al (2008) by Montenegro, Sena, Barbosa Filho and Almeida (2010) and Nogueira Neto et al (2012) measures the effect of muscle relaxation or impaired motor coordination produced by compounds in animals.…”

Section: Rota-rod Testmentioning

confidence: 99%

Alpha-terpineol: evaluation and pharmacological screening as an antidepressant agent

Assunção

Rodrigues

Sampaio

et al. 2021

RSD

View full text Add to dashboard Cite

Objective: To evaluate the possible antidepressant effects of alpha-terpineol in rodents. Material and Methods: Depression levels were analyzed by comparing the total immobility time presented by the animals of the experimental groups in the test session, using the Forced Swimming Test and the Tail Suspension Test. The parameters of locomotion (central, peripheral and total) and motor coordination were evaluated in the Open Field Test and in the Rota Rod Test, respectively. In the second stage, the involvement of the noradrenergic system in the antidepressant action of alpha-terpineol in Forced Swimming Test was investigated. Results and Discussion: After performing the experimental tests, it was observed that the animals that received alpha-terpineol had reduced immobility time in Forced Swimming Test and Tail Suspension Test, compared to the other groups. In the Open Field Test and Rota-rod, the mice showed, respectively, good exploratory activity and motor coordination during the tests. In addition, the study of the Noradrenergic System proved to be a promising mechanism used during its antidepressant action. Conclusion: In view of the results of the experimental tests, alpha-terpineol presented similar responses to those found in other monoterpenes investigated in the literature. Thus, it is shown as a promising antidepressant to be used clinically in humans, with less side effects and low production cost.

show abstract

“…However, no study has been published in scientific journals that investigated the effects of PFE on morphine withdrawal syndrome in rats. It has been reported that some species (i.e., P. spicigera ) exhibited significant antidepressant-like effect and skeletal muscle relaxant activity by using the forced swimming and tail suspension tests [ 25 ]. Another species of this genus, such as the P. juliflora , has been shown to stimulate the immune system [ 26 ] and function as an acetylcholinesterase inhibitor and butyrylcholinesterase inhibitor with Ca2+ channel blocking activity [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats

Moayeri

Azimi

Karimi

et al. 2018

Med Sci Monit Basic Res

View full text Add to dashboard Cite

BackgroundToday, the plant Prosopis farcta is frequently used for traditional medicinal purposes. The aim of this study was the identification of luteolin in P. farcta extract (PFE) and to evaluate its effect on morphine discontinuation syndrome in rats.Material/MethodsUsing high-performance liquid chromatography (HPCL), luteolin was evaluated in PFE. The frequency of behavioral symptoms of morphine withdrawal (jumping, rearing, and teeth chattering) induced by naloxone challenge were illustrated in morphine-dependent rats receiving PFE, luteolin, saline, or clonidine. LD50 of PFE and luteolin was 540 mg/kg and 150 mg/kg, respectively. Signs of behavioral morphine withdrawal in rats were significantly inhibited by chronic co-administration of PFE, luteolin, or clonidine with morphine.ResultsThis study showed that PFE was less effective than clonidine at a dose of 100 mg/kg, and at doses of 200 mg/kg and 300 mg/kg it was comparable to clonidine, and did not show a significant difference in the reduction of morphine withdrawal symptoms. Luteolin was comparable in 30 mg/kg, 60 mg/kg, and 90 mg/kg with clonidine to reduce the frequency of morphine withdrawal symptoms. PFE can be used as a source of luteolin.ConclusionsThe study findings suggest that PFE and luteolin might reduce the signs of narcotic withdrawal. Due to a similar effect to clonidine, its mechanism of action might be through the protein kinase A pathway and might have human therapeutic potential.

show abstract

Antidepressant and skeletal muscle relaxant effects of the aqueous extract of the Prosopis cineraria

Cited by 16 publications

References 5 publications

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

Prosopis Plant Chemical Composition and Pharmacological Attributes: Targeting Clinical Studies from Preclinical Evidence

Alpha-terpineol: evaluation and pharmacological screening as an antidepressant agent

Attenuation of Morphine Withdrawal Syndrome by Prosopis Farcta Extract and Its Bioactive Component Luteolin in Comparison with Clonidine in Rats

Contact Info

Product

Resources

About