2011
DOI: 10.1590/s1984-82502011000400021
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Abstract: This study aimed to obtain site-specific and controlled drug release particulate systems. Some particulates were prepared using different concentrations of sodium alginate (Na-Alg) alone and others were formulated using different proportions of Na-Alg with hydroxypropyl methylcellulose (HPMC) stearoxy ether (60M viscosity grade), a hydrophobic form of conventional HPMC, using diclofenac potassium (DP) by ion-exchange methods. Beads were characterized by encapsulation efficiency, release profile, swelling, and … Show more

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Cited by 31 publications
(14 citation statements)
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“…For the Peppas and Sahlin model (Table ), the Fickian diffusion constant ( K 1 ) was negative, whereas the constant for the process of erosion/relaxation ( K 2 ) was positive, which shows a higher effect of the relaxation process on the release of the active compounds in relation to Fickian diffusion. Similar results were observed by Ghosal and Ray, who found negative and positive values for K 1 and K 2 , respectively, which may be related to the insignificant effect of Fickian diffusion on the release of the active compounds in relation to the effect of the relaxation process.…”
Section: Resultssupporting
confidence: 88%
“…For the Peppas and Sahlin model (Table ), the Fickian diffusion constant ( K 1 ) was negative, whereas the constant for the process of erosion/relaxation ( K 2 ) was positive, which shows a higher effect of the relaxation process on the release of the active compounds in relation to Fickian diffusion. Similar results were observed by Ghosal and Ray, who found negative and positive values for K 1 and K 2 , respectively, which may be related to the insignificant effect of Fickian diffusion on the release of the active compounds in relation to the effect of the relaxation process.…”
Section: Resultssupporting
confidence: 88%
“…AVST release from nanoparticles was studied by various math ematical models described elsewhere (Ghosal;Ray, 2011). These models were applied taking into account the amount of drug released from 1 to 48 hours at different intervals as determined in release studies in-vitro.…”
Section: Kinetic Analysis Of the Release Datamentioning
confidence: 99%
“…The sustained release can be interpreted as a consequence of drug and polymer (NaAlg‐PVA) interaction, depending on pH. It has been informed that alginate at acidic pH is protonated into the insoluble form of alginic acid, and thus, penetration of dissolution fluid through the polymer can be limited (Ghosal & Ray, ). Additionally, PVA produces a compact network of macromolecular chains in the nps; thus, this polymer which is stable in acidic environment can protect encapsulated drugs from the low pH (Liu, Yao, Rao, Lu, & Gao, ;).…”
Section: Discussionmentioning
confidence: 99%