Antidiabetic and antihyperlipidemic effects of Dillenia indica (L.) leaves extract

Abstract

The present study was carried out to evaluate antidiabetic and antihyperlipidemic effects of Dillenia indica methanolic leaves extracts in streptozotocin induced diabetic Wistar rats by administering graded oral doses (250 and 500 mg/kg body weight) for 21 days. The extract showed significant antidiabetic activity (p<0.001). Furthermore, the decreased body weight of rats was significantly improved after extract treatments. Daily oral treatment with the extract for 21 days to diabetic rats, also resulted in significant reduction in serum cholesterol, triglycerides and serum transaminase levels but HDL-cholesterol level was found to be improved (p<0.001) as compared to the diabetic control group. The extract treatment also showed to enhance serum insulin level in diabetic rats as compared to the diabetic control group. In conclusion, D. indica leaf extract might be useful for diabetes mellitus management and other abnormalities associated with this metabolic disorder.Uniterms: Dillenia indica/antidiabetic effects/experimental study. Dillenia indica/antihyperlipidemic effects/experimental study. Antidiabetics/experimental study. Serum transaminase. Serum cholesterol. HDL-cholesterol level.Realizou-se o presente estudo para avaliar os efeitos antidiabético e anti-hiperlipidêmico de extratos metanólicos de folhas de Dillenia indica em ratos wistar com diabetes induzido por estreptozotocina por meio da administração de doses orais (250 e 500 mg/kg de peso corporal) por 21 dias. O extrato mostrou atividade antidiabética significativa (p<0,001). Além disso, a diminuição do peso corporal dos ratos foi significativamente melhorada após o tratamento com os extratos. O tratamento com doses orais do extrato por 21 dias aos ratos diabéticos também resultou em redução significativa do colesterol, triglicerídios e níveis de transaminase séricos, mas o nível de HDL-colesterol foi melhorado (p<0,001), quando comparado ao grupo controle diabético. O tratamento com extrato também mostrou aumento do nível sérico de insulina em ratos diabéticos comparativamente ao grupo controle diabético. Em conclusão, o extrato de folha de D. indica poderia ser útil para o controle do diabetes mellitus e de outras anormalidades associadas a essa disfunção metabólica.Unitermos: Dillenia indica/efeitos antidiabéticos/estudo experimental. Dillenia indica/efeito antihiperlipidêmico/estudo experimental. Antidiabéticos/estudo experimental. Transaminase sérica. Colesterol sérico. Nível de HDL-colesterol.

Evaluation of Antidiabetic Activity of Hydroalcoholic Extract ofCestrum nocturnumLeaves in Streptozotocin-Induced Diabetic Rats

“…Cestrum nocturnum hydroalcoholic extract showed antidiabetic effect comparable to various plants extracts like Dillenia indica [7, 8], Callistemon lanceolatus [19], and Cassia siamea [20] as reported in our previous research work. However, this is a preliminary work, and more work is needed to determine the active ingredients in the extract which may help in improving management of the antidiabetic agents.…”

“…Hyperglycemia can be handed initially with oral synthetic agent and insulin therapy. But these synthetic agents produce some serious side effects and are relatively expensive for developing countries [7]. The toxicity of oral antidiabetic agents differs widely in clinical manifestations, severity, and treatment [8].…”

Phytochemical and zootechnical studies of Physalis peruviana L. leaves exposured to streptozotocin-induced diabetic rats

“…Kumar et al (2011) reported that antidiabetic and antihyperlipidemic effects is best induced in rat models using streptozotocin-induced rat models for better comparison with test plants, and give a better result profile of the test battery. With respect to the reference group, the inability of the plant to improve the animals' weight, at the end of treatment was observed, although a stabilization of weight was recorded at the end of treatment.…”

Dilleniaspecies: A review of the traditional uses, active constituents and pharmacological properties from pre-clinical studies

“…Besides that, Kumar et al (2011a) also reported the cholesterollowering potential of the extract. It has shown to reduce the cholesterol and triglyceride level in diabetic rats after oral administration with the extract for 21 d. The anti-diabetic and antihyperlipidemic effect of methanol extract of D. indica was also reported in STZ-induced diabetic rats (Kumar et al, 2011b). Subsequently, further studies were conducted by the same group of researchers (Kumar et al, 2011c) on the antidiabetic and cholesterol-lowering properties of the bioactive fraction derived from solvent-solvent extraction of methanol extract of D. indica.…”