Development and optimization of self microemulsifying drug delivery of domperidone

Laddha, Pankaj; Suthar, Vrunda; Butani, Shital

doi:10.1590/s1984-82502011000100009

Cited by 24 publications

(17 citation statements)

References 21 publications

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“…S-SMEDDS of individual adsorbent like Neusilin US2, Aerosil 200, microcrystalline cellulose PH102 and lactose were prepared by adsorption onto carrier technique. The prepared S-SMEDDS were further evaluated for flow properties, compressibility index and characterized by Scanning electron microscopy and X-ray diffraction study (Laddha, Suthar, Butani, 2014).…”

Section: Selection Of Adsorbent For S-smeddsmentioning

confidence: 99%

Experimental design approach for development of novel microemulsion system and immediate release self microemulsifying tablet of nebivolol HCl

Trivedi

Siriah

Puranik

2020

Braz. J. Pharm. Sci.

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The objective of this study was to determine specific combination of pharmaceutical excipients that lead to formulation of efficient nebivolol hydrochloride SMEDDS and its subsequent formulation into IR-SET (Immediate release-Self emulsifying tablet) which will enhance its solubility and dissolution. Solubility and Pseudo-ternary phase studies were carried out to identify the excipients showing highest solubility and to identify the zone of microemulsion with selected ingredients. Liquid-SMEDDS (L-SMEDDS) were optimized for Concentration of oil(X1) and Smix(X2) and formulated using a combination of Kollisolv GTA as oil, Tween 80 as surfactant and propylene glycol as co-surfactant which gave smaller droplet size(Y1) 55.98nm , Emulsification time (Y2) 16±1.5 s,% transmittance (Y3) 99.94±0.47%. Neusilin US2 was used as solid carrier for solidification of L-SMEDDS in to Solid-SMEDDS (S-SMEDDS) by adsorption technique. IR-SET of nebivolol were formulated with S-SMEDDS and optimized for the concentration of binder (X1) (PVP K30) and superdisintegrant (X2) (KOLLIDON CL) which showed low Disintegration time (Y1) (92±0.5s) and low Friability(Y2)(0.424±0.03%). Also the DSC and XRD data revealed the molecular state of the drug in S-SMEDDS. The extent of in-vivo drug release and ex-vivo diffusion values from L-SMEDDS and IR-SET was much higher than pure drug and marketed tablet. In conclusion, the results showed potential of SMEDDS to improve solubility and thus the bioavailability.

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Section: Selection Of Adsorbent For S-smeddsmentioning

confidence: 99%

Experimental design approach for development of novel microemulsion system and immediate release self microemulsifying tablet of nebivolol HCl

Trivedi

Siriah

Puranik

2020

Braz. J. Pharm. Sci.

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“…Globule size (Y1) and emulsification time (Sec) (Y2) were fixed as responses to optimize SMEDDS formulation with excellent physiochemical characteristics. Appropriate design space (DS) and multiple linear regression (MLR) equations were evolved by Design-Expert Software version 7 (12,13).…”

Section: Optimization Of Smedds (Ril)mentioning

confidence: 99%

Development and Characterization of a Self-Emulsifying Drug Delivery System (Smedds) of Rilpivirine HCL

Patel¹,

Soniwala²,

Shah³

2019

Int. Res. J. Pharm.

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The present study was aimed towards to formulate and characterize self-emulsifying drug delivery system containing Rilpivirine HCl (RIL). Exhaustive Solubility study of the model drug, RIL was performed in different edible and GRAS listed oils to select oil component. Similarly, a supportive mixture of surfactants and Co-surfactants (Smix) of was selected. Pseudo-ternary diagram was plotted to judge micro emulsification existence area. The d-optimal design was employed to optimize SMEDDS composition using the amount of oil, surfactant, and Co-surfactant as independent variables and globule size and emulsification time as dependent variables. Developed SMEDDS formulations tested for self-micro emulsifying properties and the resultant formulation loaded with RIL measured for clarity, phase separation, % transmittance, globule size, and zeta potential. TEM study was performed to check the morphology of developed microemulsion globules. In vitro drug release study was undertaken and comparison was done with market formulation (Edurant ®). Out of different trials, Capryol (Oil), Labrasol (Surfactant) and Transcutol-P (Co surfactant) were selected SMEDDS components. Highest microemulsion region was found in 1:1 Smix ratio. Significant impact of selected independent variables was found on responses, which was confirmed by regression equations (Y1 and Y2) and contour plots (2D). Significant improvement in the dissolution of RIL was observed by SMEDDS as compared to pure drug and marketed formulation. Short term stability study revealed stable characteristics of developed SMEDDS.

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“…Globule Size Determination: 3,4,8,10,12,13,14 Globule size was determined for all thirty three formulations with drug. A 0.5 ml of the homogeneous mixture was measured and diluted up to 100 ml with distilled water in beaker of 100 ml.…”

Section: Ease Of Emulsification: 4 6 11 12mentioning

confidence: 99%

“…Emulsification Time: 8,11,13 Emulsification time of the SMEDDS formulations on the basis of droplet size was assessed on a USP type II dissolution apparatus (TDT 08, Electrolab, India). Formulation (800 mg) was added dropwise to 500 ml of distilled water maintained at 37 ± 0.5 °C.…”

Section: Phase Separation Study: 15mentioning

confidence: 99%

Untitled

2018

IJPSR

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Self-microemulsifying drug delivery system (SMEDDS) of Aceclofenac (ACE) was aimed at overcoming the problems of poor solubility. ACE is practically insoluble in water as a result it shows erratic oral absorption and affects the bioavailability. The formulation strategy included selection of oil phase based on saturated solubility studies and surfactant and co-surfactant screening on the basis of their emulsification ability. Ternary phase diagrams were constructed to identify the self-emulsifying region. Labrafac PG 8 (20%) as oil, tween 80 (60%) as surfactant and Polyethylene glycol 400 (20%) as cosurfactant were concluded to be optimized components. The prepared SMEDDS was characterized through its droplet size, zeta potential, emulsification time and rheological determination. The optimized formulation exhibited 98.14 ± 0.34% in-vitro drug releases, which was significantly higher than that of the drug solution. The study confirmed the potential of ACE SMEDDS for oral administration. It was concluded that the SMEDDS formulation approach can be used to improve solubility and dissolution of poorly water-soluble drugs such as ACE.

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Development and optimization of self microemulsifying drug delivery of domperidone

Cited by 24 publications

References 21 publications

Experimental design approach for development of novel microemulsion system and immediate release self microemulsifying tablet of nebivolol HCl

Experimental design approach for development of novel microemulsion system and immediate release self microemulsifying tablet of nebivolol HCl

Development and Characterization of a Self-Emulsifying Drug Delivery System (Smedds) of Rilpivirine HCL

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