Development and in vitro evaluation of sustained release multiparticulate tablet of freely water soluble drug

Abstract

Blends of aqueous dispersion of a hydrophobic and hydrophilic polymer, namely Surelease ® : hydroxypropyl methylcellulose (Surelease ® : HPMC E15) were used as coating materials to control the drug release from coated pellets of the highly water soluble drug metoprolol succinate. Varying the polymer blends, ranges of drug release patterns were obtained at pH 6.8. The present study dealt with diffusion of drug through plasticized Surelease ® / hydroxypropyl methylcellulose (HPMC E15) films prepared by coating of drug and polymers onto non-pareil seeds using the solution layering technique. The release of metoprolol succinate from coated pellets was decreased with increased coating load of polymer. The optimized formulation was obtained by 3 2 full factorial design. The release profile revealed that the optimized formulation follows zero order release kinetics. The stability data showed no interaction for storage at 25 o C and 60% relative humidity.

Development and evaluation of a novel modified release pellet-based system for the delivery of desloratadine and pseudoephedrine hydrochloride

“…The nine formulations 3 2 randomized formulated as per the experimental design [ Table 3]. [12] In vitro dissolution studies In vitro release of pellet formulations was investigated by the USP apparatus I (Basket method) the release medium was 1000 ml 0.1N HCl solution at 37±0.5°C and the rotating speed of the apparatus was set to 50 rpm for all formulations (pellets) for 1 hour then dissolution media was replaced by 7.5 pH 0.1 M phosphate buffer. At certain time intervals, 5 ml of samples were withdrawn and immediately same amount of fresh medium was added [ Table 4a-b].…”

Formulation and Evaluation of Sustained-Release Pellets of Lornoxicam

“…Pellets as a drug delivery system offer not only technological advantages but also better flow properties, less friable dosage form, narrow particle size distribution, ease of coating, and uniform packing [7,8]. It also has therapeutic advantages such as less irritation of the gastrointestinal tract, a low risk of side effects associated with dose dumping and reduction of the variation in gastric emptying rates [9,10]. Lornoxicam, also known as chlortenoxicam is a member of the oxicam group of nonsteroidal anti-inflammatory drugs (NSAIDs) with extremely potent anti-inflammatory and analgesic activities [11][12][13].…”

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“…Finally, the Carvedilol loaded pellets of step I layered with several coats of ethyl cellulose or Eudragit RS 100 referred as soft pellets (III step). By using various ratio of these pellets sustained release tablet were prepared and evaluated for further investigation to obtain best formulation, which obeys the maximum characteristics to fulfil the desired requirements 4,5,6,7 . Ethyl cellulose 5% 7% 10% 15% ----------------Eudragit RS100 ----------------5% 07% 10% 15% PEG 400 1% 1% 1% 1% 1% 1% 1% The particle size analysis of different types of pellets; drug pellets (Carvedilol), soft pellets coated with ethyl cellulose 10 cps and Eudragit RS 100 and disintegrant pellets through sieve analysis from the sieve shaker.…”