Development of enteric coated tablets from spray dried extract of feverfew (Tanacetum parthenium L: )

Abstract

Tanacetum parthenium (feverfew) is an herb that is commercialized worldwide as a therapeutic treatment for migraine. Its pharmacological effect is mainly due to the presence of the sesquiterpene lactone parthenolide as well as of flavonoids. So far, there are no studies on standardization of pre-formulations or phytomedicines containing this herb. The present study aimed at developing a pre-formulation using a standardized spray-dried extract of feverfew and further designing and standardizing enteric coated tablets. In this work, the spray-dried extract of feverfew was evaluated for its parthenolide, santin and total flavonoid content, parthenolide solubility, particle size, tapped density, hygroscopicity, angle of repose and moisture content. Tablets containing the spray-dried extract were tested for their average weight, friability, hardness, and disintegration time. The total flavonoid and parthenolide contents in the spray-dried extract were 1.31 % and 0.76% w/w, respectively. The spray-dried extract presented consistent pharmacotechnical properties and allowed its tableting by direct compression. Tablet properties were in accordance with the proposed specifications. The procedures described herein can be used to prepare and evaluate pre-formulations of feverfew with adequate properties for the development of a high-quality phytomedicine.Uniterms: Enteric coated tablets. Flavonoids. Parthenolide. Phytomedicine. Spray-dried extract. Tanacetum parthenium.Tanacetum parthenium (tanaceto) é uma planta medicinal comercializada no mundo todo para tratamento de enxaqueca. Seu efeito farmacológico é creditado principalmente à lactona sesquiterpênica partenolídeo e flavonóides. Até o momento não existem estudos sobre a padronização de pré-formulações ou o desenvolvimento de fitoterápicos com tanaceto. Logo, o objetivo deste trabalho foi obter comprimidos de revestimento entérico a partir de extrato seco e padronizado de tanaceto. Neste trabalho, o extrato seco do tanaceto obtido pelo método de spray drying foi avaliado quanto ao teor de partenolídeo, presença da santina, teor de flavonóides totais, solubilidade do partenolídeo, tamanho de partícula, ângulo de repouso, densidade, análise higroscópica e teor de umidade. A partir do extrato seco obtiveram-se comprimidos que foram revestidos em leito de jorro. Os comprimidos revestidos foram avaliados com relação ao peso médio, friabilidade, dureza e desintegração. O teor de flavonóides totais e de partenolídeo no extrato seco foram 1,31% e 0,76% (p/p), respectivamente. O extrato seco apresentou características farmacotécnicas satisfatórias permitindo a obtenção de comprimidos pelo método de compressão direta. As propriedades dos comprimidos revestidos estão de acordo com as especificações da literatura. Os procedimentos utilizados nesse trabalho podem ser utilizados para obter extrato seco e fitoterápicos de T. parthenium com alto padrão de qualidade.

Libidibia ferrea extract as a promising antidiabetic agent: characterization, pre-clinical analysis and development of pharmaceutical dosage forms / Extrato de Libidibia ferrea como um promissor agente antidiabético: caracterização, análise pré-clínica e desenvolvimento de formas de dosagem farmacêutica

“…The angle of repose and the flow time of the dry extract of L. ferrea were not possible to be obtained, since the extract showed high hygroscopicity and lack of fluidity. Unsatisfactory determinations of these tests are expected for dried plant extracts (Chaves et al, 2009). Regarding the Hausner factor and densification index, the results presented for these parameters indicate that the powder has more stable packing properties and this characteristic impairs the flowability (Table III).…”

Probiotic dried apple snacks: Development of probiotic coating and shelf‐life studies

“…Fluidized bed drying showed to be an alternative to dry some kinds of fruits because of its high heat and mass transfer between the fruit and the drying air, reducing considerably the drying time at mild temperatures (Galvão et al., 2019; Jafari & Zare, 2017; Villegas‐Santiago et al., 2011). Fluidized bed technology is also useful in coating food and pharmaceutical products during drying (Cabral et al., 2017; Chaves et al., 2009).…”

Development of DiabecineTM Tablet and Confirmation of Its Physical Properties and Pharmaceutical Safety Analysis

“…Although the traditional herbal medicines widely trusted due to their efficacy but the products are often being criticized due to lack of standardization and poor presentation (Gbenga & Olabanji 2013;Majekodunmi & Odeku 2009). Up till now, the design and formulation of herbal tablet is still very challenging task due to poor tableting properties of the herbs and their dried extract (Chaves et al 2009;Ghiware Nitin B. 2010).…”