Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

Baiak, Barbara Haline Buss; Lehnen, Cheila Roberta; Rocha, Rosilene Fernandes da

doi:10.1590/s1984-296120180093

Cited by 17 publications

(7 citation statements)

References 47 publications

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“…The anthelmintic resistance of gastrointestinal nematodes (GIN) has become an emerging problem worldwide [48][49][50][51][52][53]. Often, anthelmintics are administered without technical criteria for drug selection, empirically and indiscriminately, with additional implications for the efficacy of the products, causing the emergence and spread of anthelmintic resistance [54,55].…”

Section: Advances In the Control Of Gastrointestinal Nematodes In Pasture Animalsmentioning

confidence: 99%

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

et al. 2021

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This review describes the advances acquired and proven in the use of helminthophagous fungi in the control of gastrointestinal helminth parasites in domestic animals. Old and well-known premises about parasitic epidemiology and the factors that can interfere with the best performance of biological control are mentioned. Some of the most promising fungi are Duddingtonia flagrans from the predatory fungi group and Pochonia chamydosporia and Mucor circinelloides from the ovicidal fungi group. These fungi produce resistance spores called chlamidospores. Bioverm® and BioWorma®, based on the fungus D. flagrans, are available as commercial. Biotechnological products such as nanoparticles and obtaining primary and secondary metabolites have already been obtained from these fungi. Because they have different mechanisms of action, ovicidal and predatory fungi, when used together, can present a complementary and synergistic action in the biological control of helminths. Therefore, future research in the search for new formulations, the association of fungi from different groups, extraction of new molecules, and nanoparticles of these fungi in the control of helminths in various domestic animals are desired.

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Section: Advances In the Control Of Gastrointestinal Nematodes In Pasture Animalsmentioning

confidence: 99%

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

et al. 2021

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“…The resistance of bovine gastrointestinal nematodes to most drugs available on the market has become an emerging problem worldwide (O'Shaughnessy et al, 2014;Rose et al, 2015;Berk et al, 2016;Lobayan et al, 2017;Baiak et al, 2019). In several countries, there are high rates of resistance, such as in New Zealand (Leathwick & Luo, 2017), Australia (Bullen et al, 2016), Germany, Belgium and Sweden (Demeler et al, 2009), Sudan (Mohammedsalih et al, 2021), United States (Gasbarre, 2014) and Argentina (Cristel et al, 2017).…”

Section: Introductionmentioning

confidence: 99%

Resistance of bovine gastrointestinal nematodes to four classes of anthelmintics in the semiarid region of Paraíba state, Brazil

Melo

Sousa

Oliveira

et al. 2021

Rev. Bras. Parasitol. Vet.

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The effectiveness of four anthelmintic classes on cattle gastrointestinal nematodes in the semi-arid region of Paraiba State, Brazil, was evaluated. Twenty farms were used, testing 40 animals in each one, totaling 800 animals. Cattle were divided into four groups composed with ten animals: I, treated with albendazole sulfoxide 15%; II, treated with ivermectin 1%; III, treated with closantel 25%; IV, treated with levamisole hydrochloride 7.5%. All treatments were administered subcutaneously. For the Fecal Egg Count Reduction Test (FECRT), individual fecal samples were collected on days 0 and 14, and sent for analysis of egg count per gram of feces (EPG) and larval cultures. It was observed that multiresistance was present in 95% (19/20) of the farms. Resistance to ivermectin and albendazole was observed in 95% (19/20), to closantel in 75% (15/20) and to levamisole in 20% (4/20). The most used management system was semi-intensive (75%; 15/20) and the ivermectin was the most reported drug for controlling helminths (65%; 13/20). Haemonchus spp. was the most prevalent helminth genus. It was concluded that the anthelmintic resistance of bovine gastrointestinal nematodes is high in the semi-arid of Paraíba State, Brazil, with multiresistance observed mainly to ivermectin, albendazole and closantel.

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“…Economic losses also occur due to the costs associated with use of synthetic anthelmintic preparations. At the same time, frequent application of such preparations may not provide the necessary positive effect due to the gradual development by the parasites of resistance to anthelmintic preparations (Lyndal-Murphy et al, 2014;Dyary, 2015;Gárcia et al, 2016;Kotze & Prichard, 2016;Singh et al, 2016;Ploeger & Everts, 2018;Sangster et al, 2018;Baiak et al, 2019;Kelleher et al, 2020). Therefore, the search of alternative treatment of helmianthiases without synthetic anthelmintic preparations is a promising direction of studies on host animals and their parasites.…”

Section: Introductionmentioning

confidence: 99%

Nematicidal activity of aqueous tinctures of plants against larvae of the nematode Strongyloides papillosus

O.O.¹

2021

Trop Biomed

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This research was undertaken to evaluate the nematicidal activity of various concentrations of aqueous tinctures of 80 plant species towards L 1-2 of S. papillosus. For the experiment with larvae of S. papillosus, there were used 0.19%, 0.75% and 3.00% aqueous tinctures of plants. Out of 80 tested species, nematicidal activity against L 1-2 of S. papillosus was displayed by 20 plants. The greatest activity (LC 50 = 0.060-0.069%) towards larvae of S. papillosus was exerted by Teucrium polium, Achillea millefolium, Genista tinctoria and Ulmus laevis. Less expressed nematicidal activity (LC 50 = 0.070-0.079%) was recorded for Thalictrum minus, Stachys recta, Falcaria vulgaris, Lavatera thuringiaca. Even lower effect (LC 50 = 0.080-0.089%) was shown by aqueous tinctures of Mentha × piperita, Achillea millefolium, Salvia nutans, Eryngium campestre and Cerasus fruticosa. The following plants could be arranged in declining order of effectiveness of nematicidal activity (LC 50 = 0.090-0.165%) Malus sylvestris, Tragopogon orientalis, Erigeron annuus, Grindelia squarrosa, Urtica dioica, Daucus carota, Medicago sativa, Carduus acanthoides, Ulmus minor and Hieracium umbellatum. A far weaker effect on the nematodes was displayed by Bromopsis inermis and Tragopogon podolicus. Aqueous tinctures of 60 other studied species of plants exhibited low nematicidal activity in 3.00% aqueous tincture, while in 0.19% and 0.75% aqueous tinctures, no nematicidal activity was seen. The results of the research suggest that in the conditions of natural ecosystems, some species of plants of the Apiaceae, Asteraceae, Fabaceae, Lamiaceae, Malvaceae, Rosaceae, Ulmaceae and Urticaceae families could reduce vitality of free-living L 1-2 larvae of S. papillosus.

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Anthelmintic resistance of injectable macrocyclic lactones in cattle: A systematic review and meta-analysis

Cited by 17 publications

References 47 publications

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

Recent Advances in the Control of Helminths of Domestic Animals by Helminthophagous Fungi

Resistance of bovine gastrointestinal nematodes to four classes of anthelmintics in the semiarid region of Paraíba state, Brazil

Nematicidal activity of aqueous tinctures of plants against larvae of the nematode Strongyloides papillosus

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