Flukicide efficacy against Fasciola hepatica of Triclabendazole and Nitroxynil in cattle of the central valley of Chile

Abstract

On a farm with permanent history of fasciolasis a study was performed aimed to know the efficacy of triclabendazole (TCBZ) and then to contrast with that of nitroxynil. Thirty-nine cattle naturally infected with Fasciola hepatica were randomly allocated into 4 experimental groups: Group 1 (control) was left untreated. Group 2 was treated with of 12 mg/kg body weight (bw) of TCBZ by oral route. Group 3 treated with 24 mg/kg bw TCBZ orally. Group 4 was treated with 10 mg/kg bw of nitroxynil subcutaneously. The anthelmintic efficacy was calculated as the percentage of reduction in faecal egg count (FEC) at 14 and 28 d post-treatment. Results indicated that there were no significant differences in the percentage of FEC reduction between control group and the groups treated with 12 or 24 mg/kg of TCBZ. On the contrary, the treatment with nitroxinyl significantly reduced the FEC and decreased the percentage of positive animals. In conclusion, Fasciola hepatica is reported for first time as resistant to TCBZ in Chile, which highlights the need of rotating drugs and assessing the efficacy of the administered drug in order to avoid the selection of resistant worms.

Assessment of anthelmintic effectiveness to control Fasciola hepatica and paramphistome mixed infection in cattle in the humid tropics of Mexico

“…Unlike the results obtained in this study, the reports in Fasciola indicate that NITROX, oxyclozanide, CLOS and TCBZ are effective against F. gigantica infection at 14 post-treatments (Nzalawahe et al, 2018). Additionally, the treatment with NITROX reduced the positive animals infected with F. hepatica (Romero et al, 2019). In other study TCBZ was the most effective drug in both cattle and buffaloes with efficacy of 97.92% and 100%, respectively; Oxyclozanide and NITROX show efficacy upper to 90% at 21st day post-medication (Nzalawahe et al, 2018) There were very notable differences between farms in the effectiveness of anthelmintic.…”

“…However, in cattle in Australia, it was reported that F. hepatica was resistant to this product using FECRT by a coproantigen reduction test (CRT), and the results suggest that resistance is widespread in the southeast region of that country (Brockwell et al, 2014) and therefore other treatment alternatives, such as new drugs or vaccines, are required. Results in Chile also indicated low effectiveness with TCBZ (Romero et al, 2019). However, in Mexico, high effectiveness of TCBZ, fosfatriclaben and CLOS against F. hepatica has been reported in dairy cows (Rojas-Campos et al, 2019); in sheep, the high fasciolicidal efficiency was observed in TCBZ (Arias-García et al, 2020).…”

Tegumental alterations and resistance of Fasciola gigantica adult worms exposed to flukicides in Egypt

“…Besides, in cattle infected with F. gigantica in Tanzania, the fecal egg reduction test was 100% after nitroxynil treatment [36]. The egg reduction was significantly higher in nitroxynil-treated cattle compared with triclabendazole [37]. In addition, nitroxynil was the most potent flukicide compared with clorsulon, closentel and triclabendazole in Mexico [38].…”

Prevalencia de Fasciola hepatica y Paramphistomidae en bovinos de doble propósito en una hacienda del trópico bajo andino colombiano Digeneos en bovinos de doble propósito del trópico bajo andino colombiano

“…En la realización de este estudio se identificó la importancia de implementar la aplicación de antihelmínticos contra los digeneos encontrados en los bovinos, pues, como se mencionó, se evidenció infección patente. Por lo tanto, se sugiere suministrar tratamientos específicos contra F. hepatica y la especie de Paramphistomidae, diseñando un esquema terapéutico, que alterne el uso de moléculas (Kelley et al 2016;Romero et al 2019;Sánchez et al 2019), para impedir el fenómeno de resistencia a los medicamentos, tan denunciado en todos los continentes (Ortiz et al 2013;Novobilský y Höglund 2015). También es conveniente enfatizar en la importancia de identificar la especie de Paramphistomidae, que afecta al hato investigado, para diseñar un programa de manejo apropiado contra ese agente etiológico.…”