First autochthonous case of canine visceral leishmaniasis in Volta Redonda, Rio de Janeiro, Brazil

Campos, Monique Paiva; Silva, Denise Amaro da; Madeira, Maria de Fátima; Júnior, Artur Augusto Mendes Velho; Figueiredo, Fabiano Borges

doi:10.1590/s1984-29612013000300018

Cited by 11 publications

(10 citation statements)

References 12 publications

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“…In 2010, a case of CVL was described in the south zone of the city 11 . CAMPOS et al 4 reported the first case of CVL in the municipality of Volta Redonda and predicted the expansion of this parasitosis in non-endemic areas, as it had already been verified in Marica 8 .…”

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confidence: 71%

Geographical Expansion of Canine Visceral Leishmaniasis in Rio De Janeiro State, Brazil

Silva

Madeira

Figueiredo

2015

Rev. Inst. Med. trop. S. Paulo

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SUMMARYVisceral Leishmaniasis (VL) is a vector-borne disease that affects humans, and domestic and wild animals. It is caused by the protozoan Leishmania (Leishmania) infantum (syn = Leishmania chagasi). The domestic dog (Canis familiaris) is considered the main reservoir of the etiologic agent of VL in domestic and peridomestic environments. In the past three years, although control actions involving domestic dogs are routinely performed in endemic areas of the Rio de Janeiro State, new cases of canine visceral leishmaniasis (CVL) have been reported in several municipalities. The objective of this short communication was to describe the geographical expansion of CVL in the Rio de Janeiro State, Brazil, through its reports in the scientific literature and studies performed by our group. From 2010 to 2013, autochthonous and allochthonous cases of CVL were reported in the municipalities of Mangaratiba, Marica, Niteroi, Barra Mansa, Cachoeiras de Macacu, Volta Redonda, Resende and Rio de Janeiro. These reports demonstrate that CVL is in intense geographical expansion around the state; therefore, a joint effort by public agencies, veterinarians and researchers is needed in order to minimize and/or even prevent the dispersion of this disease.

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confidence: 71%

Geographical Expansion of Canine Visceral Leishmaniasis in Rio De Janeiro State, Brazil

Silva

Madeira

Figueiredo

2015

Rev. Inst. Med. trop. S. Paulo

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“…This disease has spread to several areas previously considered non-endemic, for example the cases reported in Rio de Janeiro State 36 and CVL outbreaks in the countryside of São Paulo State 37 . These facts justify performing surveillance surveys to prevent the spread of the disease to other animals and humans.…”

Section: Discussionmentioning

confidence: 99%

Leishmania infantum INFECTION IN DOGS FROM THE SOUTHERN REGION OF MINAS GERAIS STATE, BRAZIL

Nunes

Laurenti

Kanamura

et al. 2016

Rev. Inst. Med. trop. S. Paulo

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SUMMARYVisceral leishmaniasis is a systemic and chronic disease and dogs are the main reservoir of the etiologic agent, Leishmania infantum (syn L. chagasi). A serological and molecular investigation of canine visceral leishmaniasis (CVL) was performed in the municipality of Alfenas, located in the southern region of Minas Gerais, where the disease is not endemic. Samples from 87 dogs were submitted to serological tests including the Dual Path Platform (DPP(r) ) CVL Bio-Manguinhos rapid test, an in-house enzyme-linked immunosorbent assay (ELISA) and an immunofluorescence antibody test (IFAT), as well as molecular techniques such as a conventional polymerase chain reaction (PCR) with the RV1/RV2 primers and a quantitative PCR (qPCR) with the LinJ31, Ldon and DNApol primers. Of the 87 serum samples, eight (9.2%) were positive for Leishmania using the DPP rapid test, but only four (4.6%) were confirmed by ELISA and two (2.3%) by IFAT. In these two serologically confirmed cases, spleen and liver samples were positive by all the employed molecular and parasitological procedures performed on spleen samples. When whole blood samples were used in the molecular assays, two samples (2.3%) were positive only by qPCR. DNA extracted and amplified from the spleens of seropositive dogs was sequenced, showing 100% of similarity with the Leishmania infantum (syn L. chagasi) sequence. Thus, the first cases of CVL have been confirmed in the Alfenas region, suggesting the importance of canine surveys in non-endemic municipalities for CVL to monitor disease progression and to prevent outbreaks.

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“…Samples of skin, spleen, and liver were collected in tubes containing absolute ethanol for Polymerase Chain Reaction (PCR) or sterile saline (sodium chloride-NaCl at 58.44 g/mol) with antibiotics and antifungals (10 mg streptomycin, 25 µL amphotericin B, and 10,000 IU penicillin per mL, Sigma ® commercial solution) for culture. After being stored at 4 • C for 24 h in this solution, tissue fragments were transferred to culture tubes containing NNN medium and Schneider liquid medium [59].…”

Section: Field Proceduresmentioning

confidence: 99%

Trypanosomatids in Small Mammals of an Agroecosystem in Central Brazil: Another Piece in the Puzzle of Parasite Transmission in an Anthropogenic Landscape

et al. 2019

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We surveyed infection by Trypanosoma spp. and Leishmania spp. in small wild mammals from Cumari, Goiás State aiming to investigate the diversity of trypanosomatid in a modified landscape of the Brazilian Cerrado (and possible infection overlapping with canids from the same area). Blood, skin, spleen, and liver samples were collected for parasitological, serological, and molecular assays. Gracilinanus agilis was the most abundant species (N = 70; 48.6%) and it was the only one with patent parasitemia. Characterization by mini-exon and 18SrDNA targets were achieved in 7/10 hemocultures with positive fresh blood examination, which confirmed the T. cruzi infection by Discrete Typing Units (DTU) TcI in single (N = 2) and mixed infections with other DTUs (N = 5). T. rangeli and T. dionisii were detected in skin fragments from Didelphis albiventris and Oecomys cleberi, respectively. G. agilis were found to be infected by L. braziliensis and L. guyanensis, while Leishmania sp. DNA was detected in the liver of Oligoryzomys nigripes and Calomys expulsus. Subpatent infection by T. cruzi and Leishmania sp. was serologically detected in 15% and 9% of the small mammal fauna, respectively. Small mammals from Cumari are included in T. cruzi and Leshmania spp. transmission cycles, showing a higher diversity of trypanosomatid species and/or genotypes than that observed in canids of the same agroecosystem.

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First autochthonous case of canine visceral leishmaniasis in Volta Redonda, Rio de Janeiro, Brazil

Cited by 11 publications

References 12 publications

Geographical Expansion of Canine Visceral Leishmaniasis in Rio De Janeiro State, Brazil

Geographical Expansion of Canine Visceral Leishmaniasis in Rio De Janeiro State, Brazil

Leishmania infantum INFECTION IN DOGS FROM THE SOUTHERN REGION OF MINAS GERAIS STATE, BRAZIL

Trypanosomatids in Small Mammals of an Agroecosystem in Central Brazil: Another Piece in the Puzzle of Parasite Transmission in an Anthropogenic Landscape

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