Histopathologic findings of pulmonary acariasis in a rhesus monkeys breeding unit

Andrade, Márcia Cristina Ribeiro; Marchevsky, Renato Sérgio

doi:10.1590/s1984-29612007000400009

Cited by 11 publications

(14 citation statements)

References 9 publications

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“…However, the lesions in pulmonary acariasis appear to be multifocal distribution rather than diffuse airway inflammation, accompanied by various degrees of pyogranulomatous reaction and associated with golden-brown pigmented material, both free and within macrophages. 1 These findings are inconsistent with the present case. Hypereosinophilic syndrome was recently reported in a colony-bred owl monkey (Aotus vociferans), which was characterized by multisystemic eosinophilia affecting lung, gastrointestinal tracts, and kidney in the absence of recognizable etiology.…”

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confidence: 99%

Eosinophilic Airway Inflammation in a Cynomolgus Monkey

Shirai

Geoly

2009

Vet Pathol

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The present article describes an occurrence of eosinophilic airway inflammation of a 4-year-old female cynomolgus monkey in a vehicle control group of a routine toxicology study. Histologically, the airway lesion was characterized by prominent eosinophilic infiltrates, accompanied by mast cells, lymphocytes, and plasmacytes. The eosinophilic infiltrates were distributed throughout the airway: from trachea through respiratory bronchioles in the lung. The morphological feature of the lesion was indicative of an allergic airway disorder that can occur in humans with asthma. The present case is remarkable in that there is a paucity of reports on naturally occurring allergic airway disorders in nonhuman primates. Keywords airway, cynomolgus, eosinophilic, inflammationHuman allergic disorders, such as anaphylaxis, hay fever, eczema, and asthma, have been increasing in the developed world, with roughly 25% of the population currently being affected. 4 For many asthma patients, the disease has its roots in infancy, and factors both genetic and environmental contribute to its inception and evolution.2 Allergic asthma can be referred to as abnormal adaptive immune responses in the airway. Briefly, this begins with presentation of an allergen to naive CD4þ helper T cells by dendritic cells. Then, T-helper-2 (T H 2) cells are generated and cytokines (IL-4, IL-5, IL-13) are released from T H 2 cells. These cytokines induce activation of eosinophils (IL-5) and immunoglobulin E-producing (IgE-producing) B cells (IL-4 and IL-13) and mast cells (IL-4); subsequently, IgE binds to mast cells. After that, exposure of IgE-coated mast cells to the allergen leads to the release of proinflammatory mediators (including those stored in the cytoplasmic granules), lipid-derived mediators, and newly synthesized cytokines, chemokines, and growth factors, as well as other mediators. These induce the recruitment and activation of T H 2 cells, eosinophils, and other leucocytes and the persistent mediator production by resident cells (such as mast cells). Prolonged or repetitive exposure to specific allergens ultimately results in airway remodeling, characterized by goblet cell hyperplasia and increases in submucosal tissue, the adventitia, and smooth muscle. 4,13The animal was a captive-bred 4-year-old female cynomolgus monkey (Macaca fascicularis), which was originally from Mauritius, obtained via commercial supplier and kept at our facilities for 18 months, then assigned to a vehicle (0.5% methylcellulose) control group consisting of 3 females for a 1-month oral toxicity study. The monkeys were housed in same-sex pairs in stainless-steel cages in a single room with a temperature of 70 + 5 F (21 + 3 C), a relative humidity of 50 + 10%, a minimum of 12 air changes per hour with air filtered through 90 to 95% efficiency filters, then through highefficiency particulate air (HEPA) filters, and an approximately 12-hour light/dark cycle. A standard diet of pelleted food (Certified Primate Diet 5K91, PMI Feeds, Inc, Gray Summit, MO) supplemen...

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confidence: 99%

Eosinophilic Airway Inflammation in a Cynomolgus Monkey

Shirai

Geoly

2009

Vet Pathol

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“…The macrophages frequently contain characteristic birefringent crystalline golden brown to black pigment. The pigment is thought to be a product of the mite (Andrade and Marchevsky, 2007). The pathology of lung mite infection in baboons and chimpanzees is similar to that described for the rhesus monkey (McClure and Guilloud, 1971;Kim andKalter, 1975a, 1975b).…”

Section: Pulmonary Acariasismentioning

confidence: 72%

Respiratory System Diseases of Nonhuman Primates

Lowenstine

Osborn

2012

Nonhuman Primates in Biomedical Research

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“…The likely etiology of pulmonary bullae would be P. simicola . Many reports have shown that P. simicola can induce pulmonary bullae, and one complication of pulmonary bullae is pneumothorax in NHPs . Particularly, the prevalence of P. simicola in wild‐caught rhesus macaques is almost 100% .…”

Section: Discussionmentioning

confidence: 99%

“…Various etiology of pulmonary bullae has been reported in veterinary and human medicine. It has been reported that the lung mites (Pulmonary acariasis; Pneumonyssus simicola ) can induce pulmonary bullae in non‐human primates (NHPs) . The consequences of pulmonary bullae include pneumothorax .…”

Section: Introductionmentioning

confidence: 99%

Computed tomography or necropsy diagnosis of multiple bullae and the treatment of pneumothorax in rhesus macaques (Macaca mulatta)

Kim

Han

Shin

et al. 2017

J of Medical Primatology

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Pulmonary bullae and pneumothorax have various etiologies in veterinary medicine. We diagnosed multiple pulmonary bullae combined with or without pneumothorax by computed tomography (CT) or necropsy in seven rhesus macaques (Macaca mulatta) imported from China. Two of seven rhesus macaques accompanied by pneumothorax were cured by fixation of ruptured lung through left or right 3rd intercostal thoracotomy. Pneumonyssus simicola, one of the etiologies of pulmonary bullae, was not detected from tracheobronchiolar lavage. To the best of our knowledge, this is the first case report on the CT-aided diagnosis of pulmonary bullae and the successful treatment of combined pneumothorax by thoracotomy in non-human primates (NHPs).

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Histopathologic findings of pulmonary acariasis in a rhesus monkeys breeding unit

Cited by 11 publications

References 9 publications

Eosinophilic Airway Inflammation in a Cynomolgus Monkey

Eosinophilic Airway Inflammation in a Cynomolgus Monkey

Respiratory System Diseases of Nonhuman Primates

Computed tomography or necropsy diagnosis of multiple bullae and the treatment of pneumothorax in rhesus macaques (Macaca mulatta)

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