Uso e efetividade da papaína no processo de cicatrização de feridas: uma revisão sistemática

Leite, Andréa Pinto; Oliveira, Beatriz Guitton Renaud Baptista de; Soares, Marja Ferreira; Barrocas, Desirée Lessa Rodrigues

doi:10.1590/s1983-14472012000300026

Cited by 39 publications

(48 citation statements)

References 11 publications

(19 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…This reduction in the concentration of papain gel is required in wounds that do not have necrotic material and do not require the formation of a large amount of granulation tissue. A high concentration may cause irritation to the intact skin and result in erythema and scaling (Rocha et al, 2005;Leite et al, 2012). In agreement with a study conducted by Rocha et al (2005), which stated that the determination of the concentration of papain depends on the characteristic of the lesion, the concentrations used in the present study varied from 2 to 4% depending on the wounds or dry granulation tissue.…”

Section: Discussionsupporting

confidence: 90%

“…Several observations of the treatment with papaya preparations facilitated wound-healing responses in different etiologies such as deep burns, ulcers in diabetics, suture dehiscence, and pressure ulcers (Leite et al, 2012).…”

Section: -1206 2016mentioning

confidence: 99%

“…Studies demonstrate the safety and effectiveness of the use of papain in humans (Leite et al, 2012) and rats (Rocha et al, 2005). However, in veterinary medicine, research on papain is scarce and studies need to be conducted to verify the effectiveness of this drug in dogs.…”

Section: -1206 2016mentioning

confidence: 99%

See 2 more Smart Citations

The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: three case reports

Porsani

Carvalho

Pereira

et al. 2016

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

Papain is a proteolytic enzyme removed from the leaves of green papaya and/or latex. This enzyme is widely known as a medicinal fruit used extensively in human medicine for the treatment of wounds of various etiologies. However, studies and reports in veterinary medicine are scarce. Another herbal drug widely used in wound healing is Sunflower oil (Helianthus annus). It has inflammatory and antimicrobial properties which stimulate the local neovascularization, promoting tissue granulation, cell migration, fibroblast proliferation, and differentiation. Three dogs were treated with infected necrosis wounds, considered large, extent, and severe, with varied etiology. All cases were treated with papain gel with the exception of one dog, which was given the sunflower oil at the end of the treatment. Papain gel shows effectiveness in the treatment of wounds especially with wound debridement and removal of necrotic tissue. In addition, the healing time was shorter when compared to the treatment with sunflower oil. Finally, the herbal drugs have a low cost and high accessibility. This study contributes to create a new research regarding the use of this drug in animal wound healing. Keywords: phytotherapy, Carica papaya L, Helianthus annus, necrosis RESUMO A papaína é uma enzima proteolítica retirada do mamão-papaia verde e/ou do látex das folhas do mamoeiro, tendo propriedades medicinais conhecidas na medicina humana para tratamento de feridas

show abstract

Section: Discussionsupporting

confidence: 90%

Section: -1206 2016mentioning

confidence: 99%

See 1 more Smart Citation

The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: three case reports

Porsani

Carvalho

Pereira

et al. 2016

Arq. Bras. Med. Vet. Zootec.

View full text Add to dashboard Cite

show abstract

“…The use of papain is indicated for clean and infected wounds at different phases of the healing process, and applied at different concentrations and/or presentations, according to the type of tissue in the wound bed. Bactericidal and bacteriostatic action is also attributed to papain, however, this evidence comes from studies of research designs, which are not capable of producing strong evidence (7) .…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial activity of Eucalyptus globulus oil, xylitol and papain: a pilot study

Mota¹,

Turrini

Poveda

2015

Rev. esc. enferm. USP

View full text Add to dashboard Cite

Objective:To evaluate the in vitro antimicrobial activity of the Eucalyptus globulus essential oil, and of the xylitol and papain substances against the following microorganisms: Pseudomonas aeruginosa; Samonella sp.; Staphylococus aureus; Proteus vulgaris; Escherichia coli and Candida albicans. Method: The in vitro antimicrobial evaluation was used by means of the agar diffusion test and evaluation of the inhibition zone diameter of the tested substances. Chlorhexidine 0.5% was used as control. Results: The Eucalyptus globulus oil showed higher inhibition than chlorhexidine when applied to Staphylococcus aureus, and equal inhibition when applied to the following microorganisms: Escherichia coli, Proteus vulgaris and Candida albicans. Papain 10% showed lower antimicrobial effect than chlorhexidine in relation to Candida albicans. Xylitol showed no inhibition of the tested microorganisms. Conclusion: The Eucalyptus globulus oil has antimicrobial activity against different microorganisms and appears to be a viable alternative as germicidal agent hence, further investigation is recommended.

show abstract

“…There are many studies conducted in order to prove the effectiveness of oils and phytotherapeutics on wound healing in humans and animal species, being possible to highlight researches involving copaiba oil (CAVALCANTI NETO et al, 2005), papain (LEITE et al, 2012), sugar (LIMA et al, 2012), barbatimão (VIANA et al, 2014), passion fruit (GARROS et al, 2006), and sunflower-seed oil (MARQUES et al, 2004). Some topical preparations have already been tested in skin wounds in horses (MARTINS et al, 2003;SOUZA et al, 2006;COELHO et al, 2012.…”

Section: Introductionmentioning

confidence: 99%

Effects of topical application of pure and ozonized andiroba oil on experimentally induced wounds in horses

Araújo¹,

Teixeira²,

Lacerda³

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

View full text Add to dashboard Cite

The aim of this study was to evaluate clinical and histopathological aspects of topical application of pure and ozonized andiroba oil (Carapa guianensis Aublet.) on the healing process of wounds in healthy horses. Eight 6.25 cm 2 wounds were surgically produced on each horse, from the cranial region to the sacrum, being four wounds on each side of the lumbar region. In three animals, left side was used for macroscopic observations and area measurement and right side was used for histopathological analysis. For the other two animals, evaluations were inverted. The beginning of the topical treatment occurred 12 hours after surgical induction of the injuries and was maintained daily until complete healing of the wounds, using saline solution (GC), ozonized saline solution (GO) sequentially and bilaterally in the craniocaudal direction, pure andiroba oil (GAP) and ozonized andiroba oil (GAO). Randomly, the sequence of the treatments was modified. Macroscopic and histopathological analyses were performed at 3, 7, 14, and 21 days after surgery. The time for complete healing of all wounds was recorded. A wound contraction of 67.75% for GC, 65.26% for GO, 67.91% for GAP, and 69.84% for GAO were recorded. Histopathologic evaluation revealed that wounds from the GAO and GAP had an advanced epithelialization, fibroblast proliferation and collagen deposition, moderate vascular proliferation, and presence of PMN infiltrate and discrete viewing of MN. It was possible to conclude that all treatments had benefits when comparing to control group, concluding that both pure and ozonized andiroba oil may be good options for treating wounds in horses. Keywords: Carapa guianensis. Healing process. Equines. Wounds. Ozone. ResumoEste trabalho realizou uma avaliação clínica e histopatológica da aplicação tópica do óleo de andiroba (Carapa guianensis Aublet), puro e ozonizado, no processo de cicatrização de feridas em cinco equinos saudáveis. Oito feridas de 6,25 cm 2 foram induzidas cirurgicamente, quatro de cada lado da região lombar, craniais em relação à região sacral. Em três animais, o lado esquerdo foi destinado à avaliação macroscópica e mensuração de área, enquanto o lado direito foi destinado à análise histopatológica. Nos outros dois animais, as avaliações foram invertidas. O tratamento tópico foi iniciado 12 horas após a indução cirúrgica e foi mantido diariamente até a completa cicatrização das feridas. Foram usados, sequencialmente e bilateralmente, no sentido craniocaudal: solução salina (GC), solução salina ozonizada (GO), óleo de andiroba puro (GAP) e óleo de andiroba ozonizado (GAO). Aleatoriamente, a sequência de tratamentos foi modificada. As análises macroscópicas e microscópicas foram realizadas 3, 7, 14 e 21 dias após a cirurgia, e o tempo total para cicatrização registrado. A contração da ferida foi de 67,75% para GC, 65,26% para GO, 67,91% para GAP, e 69,84% para GAO. A avaliação histopatológica demonstrou que as feridas tratadas com GAO e GAP apresentaram uma avançada epitelização, proliferação fibroblás...

show abstract

Uso e efetividade da papaína no processo de cicatrização de feridas: uma revisão sistemática

Cited by 39 publications

References 11 publications

The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: three case reports

The use of papain gel cream and sunflower oil in promoting healing in a wound in dogs: three case reports

Antimicrobial activity of Eucalyptus globulus oil, xylitol and papain: a pilot study

Effects of topical application of pure and ozonized andiroba oil on experimentally induced wounds in horses

Contact Info

Product

Resources

About