Effect of non-surgical periodontal therapy on the levels of C-reactive protein: a pilot study

Freitas, Camila Oliveira Teixeira de; Gomes‐Filho, Isaac Suzart; Naves, Roberta Catapano; Cruz, Simone Seixas da; Santos, Carlos Antônio de Souza Teles; Barbosa, Monica Dourado

doi:10.1590/s1980-65232011000100006

Cited by 3 publications

(2 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chronic periodontitis patients either with or without atherosclerosis symptoms had increase of CRP level. 18 Chronic periodontitis patients with atherosclerosis symptoms had twice CRP level than patients without atherosclerosis s ymptoms. Other study b y De Freitas et al 19 stated that non-surgical periodontal therapy could reduce CRP level significantly.…”

Section: Methodsmentioning

confidence: 92%

Serum C-reactive protein and C-reactive gene (-717C>T) polymorphism are not associated with periodontitis in Indonesian male patients

Suhartono

Sulijaya

Djamal

et al. 2015

Dent. J. (Majalah Kedokteran Gigi)

View full text Add to dashboard Cite

Background: Periodontitis is an inflammatory disease caused by periodontal pathogens and influenced by multiple risk factors such as genetics, smoking habit, age and systemic diseases. The inflammatory cascade is characterized by the release of C-reactive protein (CRP). Periodontitis has been reported to have plausible links to increased level of CRP, which in turn has been associated to elevated risk of cardiovascular disease (CVD). Purpose: The purpose of this study was t o investigate the relationship amongst the severity of periodontitis, CRP level in blood and CRP (-717 C>T) gene polymorphism in male Indonesian smokers and non-smokers. Method: The severity of periodontitis was assessed for 97 consenting male Indonesian smokers and non-smokers. The CRP level of the subjects was determined by using immuno-turbidimetric assay performed in PARAHITA Diagnostic Center Laboratory ISO 9001: 2000 Cert No. 15225/2. The rate of CRP (-717C>T) gene polymorphism was determined by using PCR-RFLP in Oral Biology Laboratory, Faculty of Dentistry, Universitas Indonesia. Result: The results suggest that the CRP protein level is not significantly associated with the tested CRP gene polymorphism (p>0.05). Also, while the severity of periodontitis increased significantly with subject age, the CRP level in blood serum was not significantly related to the severity of periodontitis. The genotypes of the tested polymorphism did not show significant association with the severity of periodontitis either in smokers or in the combined population including smokers and non-smokers. The results naturally do not exclude such associations, but suggest that to discern the differences the sample size must be considerably increased. Conclusion: The CRP (-717C>T) gene polymorphism and CRP level in blood serum were not found to be associated with the severity of periodontitis in male smokers or in the combined population of smokers and non-smokers.

show abstract

Section: Methodsmentioning

confidence: 92%

Serum C-reactive protein and C-reactive gene (-717C>T) polymorphism are not associated with periodontitis in Indonesian male patients

Suhartono

Sulijaya

Djamal

et al. 2015

Dent. J. (Majalah Kedokteran Gigi)

View full text Add to dashboard Cite

show abstract

“…CRP also increases the expression of s CD40 ligand and MCP-1, which further accentuates the expression of cellular adhesion molecules. [ 15 16 17 ]…”

Section: Discussionmentioning

confidence: 99%

Assessment of Levels of C-Reactive Proteins and Interleukin 6 in Patients with Peri-Implantitis: A Case–Control Study

Khichy¹,

Khichy²,

Singh³

et al. 2021

Journal of Pharmacy and Bioallied Sciences

View full text Add to dashboard Cite

Aim: The present study was undertaken for assessing the C-reactive proteins (CRP) levels and IL-6 levels in patients with peri-implantitis. Materials and Methods: A total of 20 patients with confirmed clinical and radiographic diagnosis of peri-implantitis were included in the present study. Another set of 20 subjects who reported for routine health check-up were included as healthy controls. All the subjects were recalled in the morning and fasting (minimum of 12 h) venous blood samples were obtained. Plain vials were used for collecting the venous blood which was sent to the laboratory for biochemical analysis. In the laboratory, levels of CRP were assessed by means of latex enhanced nephelometric method, and interleukin 6 (IL-6) was assessed by means of Elisa kit. Results: Mean levels of CRPs in patients of the peri-implantitis group and the control group was found to be 0.795 mg/dL and 0.294 mg/dL respectively. Mean IL-6 levels among the patients of the peri-implantitis group and the control group was found to be 12.178 pg/ml and 6.458 pg/ml respectively. While analyzing statistically, significant results were obtained. Conclusion: Enhanced periodontal inflammation in peri-implantitis patients is accompanied by a considerable increase in the concentration of CRPs and IL-6.

show abstract

Avaliação da influência da doença periodontal sobre os níveis séricos de proteína C reativa

Neto

Oliveira

Martins

et al. 2020

RSD

View full text Add to dashboard Cite

Objective: To investigate the influence of periodontal disease on serum levels of C-reactive protein (CRP), evaluating the levels of this biomolecule in patients with and without periodontal disease and, in those who have periodontal disease, evaluating the levels of this protein before and after periodontal treatment. Methodology: The research was carried out with 82 patients seen at the Clinic-School of Dentistry of the Federal University of Campina Grande, campus Patos-PB. The individuals were divided into two groups, one consisting of 42 patients with healthy periodontium and the other composed of 40 patients with periodontal disease. Among the individuals in the group with periodontal disease, 11 were reassessed one week after the completion of periodontal treatment. Results: CRP concentrations were significantly higher in the group with periodontal disease (6.09 ± 1.34 mg / l, n = 40) compared to the control group (2.93 ± 0.55 mg / l, n = 42). The results also showed that periodontal treatment reduced CRP values (3.76 ± 0.92 mg / l, n = 11) when compared to values before treatment (10.58 ± 3.69 mg / l, n = 11), however, with no statistically significant difference. Conclusion: It is observed that CRP levels are significantly increased in the serum of patients with periodontal disease compared to patients with healthy periodontium and that lower CRP levels were observed after non-surgical periodontal therapy. The results indicate that periodontal disease interferes with serum CRP levels, and that periodontal treatment can have a positive effect in reducing this protein.

show abstract

Effect of non-surgical periodontal therapy on the levels of C-reactive protein: a pilot study

Cited by 3 publications

References 0 publications

Serum C-reactive protein and C-reactive gene (-717C>T) polymorphism are not associated with periodontitis in Indonesian male patients

Serum C-reactive protein and C-reactive gene (-717C>T) polymorphism are not associated with periodontitis in Indonesian male patients

Assessment of Levels of C-Reactive Proteins and Interleukin 6 in Patients with Peri-Implantitis: A Case–Control Study

Avaliação da influência da doença periodontal sobre os níveis séricos de proteína C reativa

Contact Info

Product

Resources

About