2010
DOI: 10.1590/s1980-57642010dn40100012
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Efficacy and safety of brand-risperidone versus similar-risperidone in elderly patients with neuropsychiatric disorders: A retrospective study

Abstract: To compare the efficacy and tolerability of brand-risperidone against similar-risperidone in elderly outpatients.MethodThe medical files of 16 elderly outpatients from the IPq-HCFMUSP treated with two formulations of risperidone (brand and similar) between July/1999 and February/2000 were reviewed. Two independent raters, using the Clinical Global Impression scale, evaluated the efficacy of the treatment with risperidone and the frequency of adverse effects.ResultsComparing October/1999 to November/1999, Rater… Show more

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Cited by 2 publications
(2 citation statements)
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“…It also involves an antagonistic action on 5-HT2a in post-synaptic receptors, which can have direct antipsychotic effects as well as indirect antipsychotic effects (via promoting D2 antagonism). In addition, antagonism on post-synaptic 5-HT2a receptors can regulate the firing of dopamine (DA) neurons, leading to an increase in the amount of DA released by the dorsal striatum, the prefrontal cortex, and the nigrostriatal region 1,2 The lactotrophs in the anterior pituitary gland are largely responsible for synthesizing prolactin and its subsequent release. Prolactin is a single-chain protein with 199 amino acids and a molecular weight of 23 kilodaltons.…”
Section: Introductionmentioning
confidence: 99%
“…It also involves an antagonistic action on 5-HT2a in post-synaptic receptors, which can have direct antipsychotic effects as well as indirect antipsychotic effects (via promoting D2 antagonism). In addition, antagonism on post-synaptic 5-HT2a receptors can regulate the firing of dopamine (DA) neurons, leading to an increase in the amount of DA released by the dorsal striatum, the prefrontal cortex, and the nigrostriatal region 1,2 The lactotrophs in the anterior pituitary gland are largely responsible for synthesizing prolactin and its subsequent release. Prolactin is a single-chain protein with 199 amino acids and a molecular weight of 23 kilodaltons.…”
Section: Introductionmentioning
confidence: 99%
“…Embora os antipsicóticos atípicos também possam apresentar reações adversas que prejudiquem a comunicação adequada do indivíduo, como por exemplo a clozapina, que também pode ocasionar alterações na mobilidade oromiofacial em decorrência de hipotonia muscular (DURÃO, 2004). A risperidona é outro antipsicótico que pode trazer efeitos indesejáveis relacionados à expressão verbal, como por exemplo, a rigidez muscular em alguns casos (FOLQUITTO et al, 2010).…”
Section: Modalidades De Tratamentounclassified