The impact of cognitive performance on quality of life in individuals with Parkinson's disease

Abstract

BackgroundEvidence points to the occurrence of cognitive impairment in all stages of PD, constituting a frequent and debilitating symptom, due to high impact on quality of life and mortality of patients.ObjectiveTo correlate cognitive performance with quality of life in PD.MethodsThe sample was drawn from a Movement Disorders Clinic of a reference hospital in Porto Alegre. Inclusion criteria were: PD diagnosis, according to the United Kingdom Parkinson's Disease Society Brain Bank criteria for idiopathic PD (Hughes et al. 1992) and patient consent to participate. Patients with other neurological pathologies and those submitted to deep brain stimulation were excluded. The evaluation consisted of a cognitive testing battery (composed of eight tests for assessing cognitive performance), and a questionnaire on quality of life (PDQ-39) and depression (BDI).ResultsThe sample comprised 85 individuals with PD, with a mean age of 62.9 years (±10.7), mean disease duration of 10.4 years (±5.7), and mean educational level of four years (±4.3). There was a significant relationship between total score on the PDQ and all cognitive tests, showing that poor cognitive performance was correlated with poor quality of life. Moreover, a significant correlation was observed between cognitive tests and depression, H&Y, education level, and age.ConclusionIt may be concluded that the individuals with PD in this sample showed a correlation between poorer quality of life and worse cognitive performance. Poor performance was also correlated with more advanced stage, older age, low level of education and depression.

Nordic Walking and Free Walking Improve the Quality of Life, Cognitive Function, and Depressive Symptoms in Individuals with Parkinson’s Disease: A Randomized Clinical Trial

“…Changes in the central nervous system resulting from Parkinson’s disease (PD) lead to the manifestation of non-motor symptoms, such as cognitive deficits and increased depressive symptoms [ 1 , 2 ]. The severity of non-motor and motor symptoms, in turn, is causally related to deficits in quality of life (QoL) [ 3 , 4 ]. Furthermore, some studies show the influence of sedentary time on factors associated with quality of life in people with PD [ 5 ].…”

“…From a mechanistic standpoint, enhanced cognitive function implies mitigating not just movement disorders but also non-motor symptoms including autonomic dysfunction, sleep disorders, and pain [ 4 , 5 , 14 ]. Although positive motor and clinical adaptation using Nordic walking in patients with PD have been shown [ 10 , 12 , 15 , 16 ], to the best of our knowledge no data have been reported about the effects of Nordic walking in comparison to a free walking training program on QoL and non-motor symptoms in individuals with PD.…”

The control of language production and its neural substrates in Parkinson's disease

“…For example, in their population-based study, Schrag, Jahanshahi, and Quinn (2000) identified a significant correlation between results on the Mini-Mental State Exam (Folstein, Robins, & Helzer, 1983) and the Parkinson's Disease Questionairre-39 (a PD specific measurement of quality of life; Peto, Jenkinson, & Fitzpatrick, 1998). A similar relationship between cognitive decline and quality of life has also been replicated more recently by Olchik, Ayres, Ghisi, Schuh, and Rieder (2016). In addition, the presence of significant cognitive deficits has been linked to greater caregiver distress or burden (Aarsland, Larsen, Karlsen, Lim, & Tandberg, 1999;Lawson et al, 2016;Leroi, McDonald, Pantula, & Harbishettar, 2012) and higher incidence of nursing home admission (Aarsland, Larsen, Tandberg, & Laake, 2000).…”

Efeitos de um treino de marcha associado à prática mental sobre o desempenho da marcha em pacientes com doença de Parkinson

“…A prevalência de déficit cognitivo leve em estágios iniciais é de 15-25% e aproximadamente 50% das PDP desenvolvem demência nos primeiros 10 anos do curso da doença (OLCHIK et al, 2016).…”

“…Alguns fatores contribuem para que o indivíduo tenha maior propensão a desenvolver déficits cognitivos, são eles: idade avançada, baixa escolaridade, rigidez, instabilidade postural, distúrbios do sono REM, alucinações e substância branca afetada (OLCHIK et al, 2016).…”