Voxel-based morphometry in Alzheimers disease and mild cognitive impairment: Systematic review of studies addressing the frontal lobe

Ribeiro, Luís Gustavo de Imparato Rodrigues; Filho, Geraldo Busatto

doi:10.1590/s1980-5764-2016dn1002006

Cited by 14 publications

(6 citation statements)

References 53 publications

(134 reference statements)

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“…Previous imaging studies have reported that reduced GMV or cortical thickness is associated with cognitive decline in healthy or aging populations ( 38 ). Also, frontal GMV reduction is most affected, including the middle, inferior, and superior frontal gyri in patients with AD or in patients with mild cognitive impairment who developed AD ( 39 ). Our results support previous findings that cortical GMV was affected mainly in the frontal cortices of individuals with obesity.…”

Section: Discussionmentioning

confidence: 99%

Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

Ge¹,

Zheng²,

Mei³

et al. 2023

Journal of Clinical Investigation

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Section: Discussionmentioning

confidence: 99%

Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

Ge¹,

Zheng²,

Mei³

et al. 2023

Journal of Clinical Investigation

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“…Consistent with the antagonistic pleiotropic effect of APOE ε4 in controls, greater surface area in this region has been associated with better executive functioning (Boisgueheneuc et al, 2006; Nissim et al, 2017). Of note, there is evidence of reduced grey matter volume in the superior frontal gyrus in AD (Ribeiro and Busatto Filho, 2016). Although the post hoc contrasts for this cluster were not significant, the fact that the cluster emerged was not expected based on prior studies.…”

Section: Discussionmentioning

confidence: 99%

Neurostructural and neurocognitive correlates of APOE ε4 in youth bipolar disorder

et al. 2023

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Background: Bipolar disorder (BD) is a clinical risk factor for Alzheimer’s disease (AD). Apolipoprotein E ε4 ( APOE ε4), a genetic risk factor for AD, has been associated with brain structure and neurocognition in healthy youth. Aims: We evaluated whether there was an association between APOE ε4 with neurostructure and neurocognition in youth with BD. Methods: Participants included 150 youth (78 BD:19 ε4-carriers, 72 controls:17 ε4-carriers). 3T-magnetic resonance imaging yielded measures of cortical thickness, surface area, and volume. Regions-of-interest (ROI) and vertex-wise analyses of the cortex were conducted. Neurocognitive tests of attention and working memory were examined. Results: Vertex-wise analyses revealed clusters with a diagnosis-by- APOE ε4 interaction effect for surface area ( p = 0.002) and volume ( p = 0.046) in pars triangularis (BD ε4 -carriers > BD noncarriers), and surface area ( p = 0.03) in superior frontal gyrus (controls ε4 -carriers > other groups). ROI analyses were not significant. A significant interaction effect for working memory ( p = 0.001) appeared to be driven by nominally poorer performance in BD ε4 -carriers but not control ε4 -carriers; however, post hoc contrasts were not significant. Conclusions: APOE ε4 was associated with larger neurostructural metrics in BD and controls, however, the regional association of APOE ε4 with neurostructure differed between groups. The role of APOE ε4 on neurodevelopmental processes is a plausible explanation for the observed differences. Future studies should evaluate the association of APOE ε4 with pars triangularis and its neurofunctional implications among youth with BD.

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“…The VBM toolbox in the Statistical Parametric Mapping software (SPM 12, http://www.fil.ion.ucl.ac.uk/spm/software/spm12) implemented in MATLAB was used to pre- process structural images (2, 44, 45).…”

Section: Methodsmentioning

confidence: 99%

Seed-based morphometry of nodes in the default mode network among patients with Alzheimer’s disease in Klang Valley, Malaysia

Mohad Azmi,

Suppiah,

Nabila Ibrahim

et al. 2023

Preprint

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The default mode network (DMN) is a prominent neural network in the human brain that exhibits a substantial association with Alzheimer's disease (AD). Functional connectivity (FC) and grey matter volume (GMV) were reported to differ between AD and healthy controls (HC). Nevertheless, available evidence is scarce regarding the structural and functional alterations observed in individuals diagnosed with Alzheimer's disease (AD) within the context of Malaysia. A prospective cross-sectional study was conducted in the Klang Valley region of Malaysia. A total of 22 participants were enlisted for the study, following a thorough clinical assessment completed by geriatricians. The participants underwent a series of neuropsychological tests, including the Montreal Cognitive Assessment (MoCA), Mini-Mental State Examination (MMSE), and Clinical Dementia Rating (CDR). The participants were classified into two groups, namely AD (Alzheimer's disease) and HC (healthy controls), before the acquisition of resting-state functional magnetic resonance imaging (Rs-fMRI) images. The analysis of voxel-based morphometry (VBM) was conducted using SPM 12, a widely used software package in the field of neuroimaging, implemented in MATLAB. The primary objective of this analysis was to assess the grey matter volume (GMV). The CONN toolbox was employed to assess the functional connectivity (FC) and activation patterns of the nodes inside the default mode network (DMN). In this pilot project, a cohort of 22 participants was enlisted, consisting of 11 individuals with Alzheimer's disease (AD) with an age range of 64-84 years and 11 healthy controls (HC) with an age range of 64-79 years. In the Alzheimer's disease (AD) group, there was a reduction in grey matter volume (GMV) observed in several brain regions when compared to the healthy control (HC) group. Specifically, decreased GMV was found in the right and left inferior temporal gyrus, left superior frontal gyrus, right superior frontal gyrus medial segment, right gyrus rectus, right temporal lobe, left putamen, and right precuneus, respectively. The significance level for the Rs-FC analysis was established at a cluster-size corrected p-value of less than 0.05. A notable reduction in the activation of the nodes within the default mode network (DMN) was observed in individuals with Alzheimer's disease (AD) compared to healthy controls (HC). This drop was notably evident in the functional connectivity of the precuneus and anterior cingulate cortex in both AD and HC groups, as well as in the comparison between AD and HC groups. Resting-state functional magnetic resonance imaging (fMRI) can identify specific imaging biomarkers associated with Alzheimer's disease by analysing grey matter volume (GMV) and default mode network (DMN) functional connectivity (FC) profiles. Consequently, there is promise for utilising resting-state fMRI as a non-invasive approach to enhance the detection and diagnosis of Alzheimer's disease within the Malaysian community.

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Voxel-based morphometry in Alzheimers disease and mild cognitive impairment: Systematic review of studies addressing the frontal lobe

Cited by 14 publications

References 53 publications

Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

Butyrate ameliorates quinolinic acid–induced cognitive decline in obesity models

Neurostructural and neurocognitive correlates of APOE ε4 in youth bipolar disorder

Seed-based morphometry of nodes in the default mode network among patients with Alzheimer’s disease in Klang Valley, Malaysia

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