Expressão da p53 no tumor e no epitélio oral em pacientes com câncer de boca e faringe

Abstract

Introduction:Expressive percent of patients with oral and oral pharynx carcinomas presents with overexpression of protein p53 induced by tobacco, alcohol and radiotherapy. Objective:To describe the p53 expression in areas of the normal mucosa adjacent to the tumor and in mouth and pharynx carcinomas. Method:Prospective study with clinical follow-up of one year of 24 patients with oral and oral pharynx spinocellular carcinoma. We performed biopsies in the neoplasm and areas of the normal mucosa adjacent to the tumor, before and 9 months following radiotherapy and an immunohistochemical study of p53 expression. Results:Before radiotherapy, there was a change to the p53 expression in 20 out of the 24 biopsies made in the neoplasm and in 14 in those of normal mucosa adjacent to the tumor. Eleven patients died 1 year before clinical follow-up. From the 2 initial patients with increase of p53 after radiotherapy it remained increased in 7 in the neoplasm region and in 6 in the normal mucosa regions. We noticed association of p53 with smoking and tumor stage (p < 5%), but not with the degree of cellular differentiation and alcoholism. Conclusion:The increase to the p53 expression was viewed both in the neoplasm region and in the normal mucosa in most patients with oral and oral pharynx carcinoma before and after radiotherapy. There was a statistically significant correlation of the p53 expression with smoking and neoplasm stage.

Alterações fonoaudiológicas e acesso ao fonoaudiólogo nos casos de óbito por câncer de lábio, cavidade oral e orofaringe: um estudo retrospectivo

“…The search pattern can vary according to sex, age, social groups, and the use may depend on the health problems and disease severity, specific procedures and geographic areas in which the patient or the service are 29,30 . Thus, the access to speech therapy service is also another complicating factor for the entry and maintenance of the therapy, since most users is SUS-dependent and therefore the high demand of patients, with the low supply of professionals 28,29 leads to extend the waiting time to begin the speech therapy.…”

Câncer De Boca Em Mulheres Jovens: Estudo Dos Fatores De Risco / Oral Cancer in Young Women: Study of Risk Factors

“…A associação entre o fumo e o álcool na etiologia do câncer de boca está relacionada com esse efeito de aumento da permeabilidade causado pelo álcool, que pode ocasionar um aumento da penetração dos carcinógenos presentes no tabaco (SANTOS et al, 2011).…”