A frequência do HPV na mucosa oral normal de indivíduos sadios por meio da PCR

Abstract

The human papillomavirus (HPV) is a DNA virus, which belongs to papillomaviridae family, being of low and high risk, which infect the skin and mucous membranes and can induce benign and malign tumor formation. In the oral mucosa they have been associated with oral papilloma, focal epithelial hyperplasia, leucoplakia and oral neoplasia. Aim: to study the frequency of HPV finding in oral mucosa of normal people. Materials and methods: Prospective study, cross-sectional cohort. One hundred volunteers, young adults, healthy, aged between 20 and 31 years, university students with no history, no complains, without oral or oropharyngeal lesions. They were submitted to a questionnaire with questions regarding HPV infection epidemiology. The samples were harvested by brushing and analyzed by PCR. Results: The results were negative for HPV in all samples. Conclusion: It seems we had high social and economical class individuals, with nutrition rich in carotenoyds and vitamin C, low smoking and alcohol consumption and heterosexual habits with predominant monogamy and regular use of condoms.

The prevalence of human papillomavirus in patients with oral lichen planus and normal oral mucosa

“…A japanese study (13) reported higher HPV positivity. Data from Brazil, on the other hand, show that there was not a single case of HPV in healthy mucosa (14). Th e age of subjects in this study, however, was between 20-31 years and all were university students, which suggests that a higher socioeconomic status may play a role in these fi ndings.…”

Prevalência do papilomavírus humano (HPV) em Belém, Pará, Brasil, na cavidade oral de indivíduos sem lesões clinicamente diagnosticáveis

“…Esquenazi et al 6 verificaram ausência de HPV nos 100 voluntários universitários pesquisados no Rio de Janeiro. Baixas prevalências foram encontradas por Ammatuna et al 7 (3,3%) e Migaldi et al 8 na Itália (1,2%).…”

“…O HPV 16 é o tipo mais comum associado ao câncer oral e ao de colo de útero, enquanto os tipos 6 e 11 são mais frequentes em lesões benignas e pré-malignas e raramente nas lesões neoplásicas da cabeça e do pescoço. Os achados comuns dos mesmos tipos de HPV (6,11, 16 e 18) em mucosa oral e genital são um forte indicativo para a transmissão orogenital 2,3,4 .…”

Elevated prevalence of high-risk HPV in healthy oral mucosa of users and nonusers of drugs in Northeastern Brazil

“…1 Approximately 200 HPV types have been identified and classified into high or low oncogenic risk groups. 2 In the oral cavity, benign lesions are mainly associated with the types 2, 4, 6, 7, 11, 13 and 32, which are of low oncogenic risk. Other types (16,18,31,33,35,39,45,51,52,56,58,59 and 66) of high oncogenic risk are associated with malignant lesions of the oral cavity, mainly squamous cells.…”

“…Other types (16,18,31,33,35,39,45,51,52,56,58,59 and 66) of high oncogenic risk are associated with malignant lesions of the oral cavity, mainly squamous cells. 2,3 In Brazil, 500,000 to 1 million cases of HPV infections are estimated annually. 1 Detection rates for HPV in healthy oral mucosa vary significantly around the globe, suggesting that this site may work as a reservoir for Declaration of Interests: The authors certify that they have no commercial or associative interest that represents a conflict of interest in connection with the manuscript.…”