Association between vitamin d levels and adolescent idiopathic scoliosis

Batista, Rodrigo; Martins, Délio Eulálio; Wajchenberg, Marcelo; Lazaretti, Marise; Puertas, Eduardo Barros; Terreri, Maria Teresa; Hayashi, Lilian Fukusima

doi:10.1590/s1808-18512014130400432

Cited by 12 publications

(31 citation statements)

References 10 publications

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“…Recent studies indicate an interaction between 25-OHD deficiency and development of AIS, 11 , 12 which was corroborated in our study: almost all of the patients (97%) had lower 25-OHD levels than expected. Considering the small number of studies suggesting a correlation between 25-OHD and AIS, further studies are needed to support this hypothesis and to the reasons behind this variation.…”

Section: Discussionsupporting

confidence: 91%

Role of Different Hormones in the Pathogenesis and Severity of Adolescent Idiopathic Scoliosis

et al. 2017

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Objective: To evaluate the hormonal profile of patients with adolescent idiopathic scoliosis (AIS) and its relationship to the severity of the curvature and quality of life . Method: Patients with scoliosis (Cobb angle above 10°), of both genders, diagnosed after 10 years of age were included, excluding those who presented other condition that could lead to scoliosis. Serum levels of 25-hydroxyvitamin D (25-OHD), cortisol and gastrin were correlated with Cobb angle and quality of life, measured by the SRS-30 questionnaire . Results: The levels of 25-OHD decreased in 97% of patients. There was an inverse relationship between gastrin levels and quality of life (p = 0.016). Moreover, there was an inverse correlation between the value of Cobb angle and quality of life (p = 0.036). There were no changes in cortisol levels. There was no correlation between Cobb angle and any of the hormones measured . Conclusion: The patients had levels of 25-OHD diminished, strengthening the hypothesis of its involvement in the development of AIS. This study also suggests that increased gastrin levels may be associated with a worse quality of life in patients with AIS. Level of Evidence II, Diagnostic Study.

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Section: Discussionsupporting

confidence: 91%

Role of Different Hormones in the Pathogenesis and Severity of Adolescent Idiopathic Scoliosis

et al. 2017

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“…Acquired vitamin-D disorders include primary hyperparathyroidism and hyperthyroidism, whereas genetic disorders include pseudovitamin-D deficiency rickets, vitamin-D resistant rickets, autosomal dominant hypophosphatemic rickets, and X-linked hypophosphatemic rickets [8]. Of specific relevance to our study is the recently published study by Batista et al [13], in which there were lower serum levels of vitamin D in patients with AIS compared with age-matched controls with no spinal deformity, with no relationship found between vitamin-D levels and BMI. For the 55 patients with AIS in their study, Batista and colleagues reported an overall mean serum vitamin-D levels of 18.83 7.9 ng/ ml, with 34 patients (62%) having levels below the cutoff threshold of 20 ng/ml, 16 patients (29%) with levels in the 20-30 ng/ml range, and five patients (9%) with levels above the 30 ng/ml threshold for normal levels.…”

Section: Discussionmentioning

confidence: 89%

“…For the 55 patients with AIS in their study, Batista and colleagues reported an overall mean serum vitamin-D levels of 18.83 7.9 ng/ ml, with 34 patients (62%) having levels below the cutoff threshold of 20 ng/ml, 16 patients (29%) with levels in the 20-30 ng/ml range, and five patients (9%) with levels above the 30 ng/ml threshold for normal levels. In comparison, in their control group of 60 patients, the overall mean vitamin-D level was 27.05 7.12 ng/ml, with 11 patients (18.3%) having levels below 20 ng/ml, 27 (45%) patients having levels in the range of 20-30 ng/ml, and 22 (36.7%) patients having above the normal threshold of 30 ng/ml [13]. Our results are comparable to those of Batista and colleagues, with a mean serum vitamin-D level of 17.13 8.44 ng/ml (median, 16.14 ng/ml; range, 2.8-54.8 ng/ml) for patients with AIS (group 1) compared with 21.55 14.75 ng/ml (median, 17.25 ng/ml; range, 1.3-116.1 ng/ml) for patients in group 2 (P < 0.0001).…”

Section: Discussionmentioning

confidence: 89%

“…Moreover, vitamin-D insufficiency can have negative effects on bone health in older children and adolescents [15]. In addition, a decrease in vitamin-D level has been reported for adolescents with idiopathic scoliosis compared with that in a normal age-matched population [6,13]. Across different studies using the level of serum 25(OH)-D as an indicator of vitamin-D status, 20 ng/ml or less is classified as a vitamin-D deficiency, levels between 21 and 29 ng/ml as a vitamin-D insufficiency, and levels of 30 ng/ml or greater as normal levels, with a preferred range of 40-60 ng/ml [16][17][18][19].…”

Section: Discussionmentioning

confidence: 99%

“…In addition, recent studies have shown a relationship between gene polymorphisms of vitamin-D receptors (VDRs) and osteoporosis [10,11]. Both osteoporosis and vitamin-D deficiency have specifically been associated with AIS [6,12,13]. As the persistence of low bone mass in patients with AIS through adulthood would increase their risk for developing osteoporosis and osteoporosis-related complications in later life [3,4], understanding the relationship between vitamin D and the AIS process is clinically meaningful to identify optimal intervention strategies for these adolescents.…”

Section: Introductionmentioning

confidence: 99%

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Vitamin-D measurement in patients with adolescent idiopathic scoliosis

Balioğlu

Aydin

Kargın

et al. 2017

Journal of Pediatric Orthopaedics B

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Our retrospective study compared vitamin-D levels in 229 patients with adolescent idiopathic scoliosis (AIS) and 389 age-matched controls, and evaluated the correlation between vitamin-D levels and sex, Cobb's angle, and serum levels of calcium (Ca), phosphorus, and alkaline phosphatase in the AIS group. Vitamin-D levels were lower in the AIS group, with no sex-specific effects, indicative of a possible vitamin-D resistance in AIS. Vitamin-D levels correlated positively with Ca levels and negatively with Cobb's angle, indicative of a possible role of vitamin D in the etiopathogenesis of AIS. Patients with AIS should be monitored for vitamin-D deficiency/insufficiency.

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Association between calcium-phosphorus balance and adolescent idiopathic scoliosis: A meta-analysis

Zhu¹,

Chang-xian²,

Wang³

et al. 2019

Acta Orthopaedica et Traumatologica Turcica

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Study designA systematic review and meta-analysis.ObjectiveThe objective of this meta-analysis was to evaluate the association between calcium-phosphorus balance and adolescent idiopathic scoliosis (AIS).MethodsDatabases, including PubMed, OVID database, Web of Science, CBM database and CNKI database were searched for the relevant case control studies and cross-sectional studies. Two authors selected studies and extracted data independently. Data analysis was performed by Review Manager Software 5.0. Subgroup analysis was performed on the serum level of vitamin D according to gender and menstruation.ResultsFive studies were included, with a total of 646 cases of AIS and 791 controls. AIS group had a lower serum level of vitamin D compared to control group [MD = −6.74, 95% CI (−9.47, −4.00)]. Gender and menstruation condition were thought to have no effect on the primary outcome of vitamin D level by subgroup analysis [MD = −5.97, 95% CI (7.61, −4.34)]. The AIS group had a lower calcium level [SMD= −0.77, 95% CI (−1.51, −0.02)] and calcitonin level compared to control group. There was no statistical difference in phosphorus level [SMD=0.5, 95% CI (−0.46, 0.57)] and parathyroid hormone level [SMD = −0.11, 95% CI (−0.54, −0.31)]. Meanwhile, the observational indexes, including serum levels of calcium, phosphorus, parathyroid hormone and calcitonin were within normal limits.ConclusionVitamin D deficiency may be involved in the pathogenesis of AIS by influencing the regulation of calcium-phosphors metabolism on human bone. Therefore, we suggest to screen vitamin D level in AIS patients.Level of EvidenceLevel III, Therapeutic Study

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Association between vitamin d levels and adolescent idiopathic scoliosis

Cited by 12 publications

References 10 publications

Role of Different Hormones in the Pathogenesis and Severity of Adolescent Idiopathic Scoliosis

Role of Different Hormones in the Pathogenesis and Severity of Adolescent Idiopathic Scoliosis

Vitamin-D measurement in patients with adolescent idiopathic scoliosis

Association between calcium-phosphorus balance and adolescent idiopathic scoliosis: A meta-analysis

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