2011
DOI: 10.1590/s1807-59322011001300005
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Abstract: Cellular energy metabolism is one of the main processes affected during the transition from normal to cancer cells, and it is a crucial determinant of cell proliferation or cell death. As a support for rapid proliferation, cancer cells choose to use glycolysis even in the presence of oxygen (Warburg effect) to fuel macromolecules for the synthesis of nucleotides, fatty acids, and amino acids for the accelerated mitosis, rather than fuel the tricarboxylic acid cycle and oxidative phosphorylation. Mitochondria b… Show more

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Cited by 105 publications
(79 citation statements)
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References 143 publications
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“…Peritumoral edema showed significantly lower values of this metabolite ratio than the solid tumor part, but with respect to the tumor center, the significance was not confirmed. The lowest values of the Lac/tCr among all investigated brain areas were observed in the healthy tissue, taking into account that the only nonsignificant differences were related to the peritumoral a high tumor cells proliferation and thus also increased density of cell membranes in tumorous tissue area (Lupo et al 2007;Schneider et al 2010;Marie and Shinjo 2011). Membrane phospholipids are beneficial for spectroscopic tumor detection.…”
Section: Resultsmentioning
confidence: 92%
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“…Peritumoral edema showed significantly lower values of this metabolite ratio than the solid tumor part, but with respect to the tumor center, the significance was not confirmed. The lowest values of the Lac/tCr among all investigated brain areas were observed in the healthy tissue, taking into account that the only nonsignificant differences were related to the peritumoral a high tumor cells proliferation and thus also increased density of cell membranes in tumorous tissue area (Lupo et al 2007;Schneider et al 2010;Marie and Shinjo 2011). Membrane phospholipids are beneficial for spectroscopic tumor detection.…”
Section: Resultsmentioning
confidence: 92%
“…However, not all cancer cells have impaired mitochondrial function (Kroemer and Pouyssegur 2008;Cairns et al 2011) and despite of that only about 10% of the glycolytic pyruvate enters the Krebs cycle (de Souza et al 2011). The reason is that for tumor metabolism could be a typical so-called Warburg effect, when cells prefer anaerobic rather than aerobic glycolysis, despite the sufficient presence of oxygen (DeBerardinis et al 2008;Hsu and Sabatini 2008;Marie and Shinjo 2011). This deficiency is compensated by overexpression of glucose transporters leading to 20-to 30-fold increased import of glucose into the tumorous cell (Ganapathy et al 2009), higher expression and activity of glycolytic enzymes, especially of hexokinase, phosphofructokinase and pyruvate kinase (Diaz-Ruiz et al 2009;Ordys et al 2010;Cairns et al 2011), resulting in 30-fold acceleration of glycolysis (Ganapathy et al 2009).…”
Section: Discussionmentioning
confidence: 99%
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“…Many pathways of cancer tumorigenesis, angiogenesis, tumor cell growth, apoptosis, and therapy resistance have been recognized in combination with cellular metabolism. [14] For instance, Puzio-Kuter mentioned that p53 tumor suppressor has an important role in cancer pathways as it can influence several aspects of metabolism through different mechanisms. The p53 promotes a variety of cellular responses to hypoxia, DNA damage, and oncogene activation; however, recently it has been found to regulate glycolysis and assist in maintaining mitochondrial integrity.…”
Section: Metabolism Of Tumor Cellsmentioning
confidence: 99%
“…[16] One of the most active signaling pathway in many cancers is stress-responsive PI3K/AKT mechanism which is linked to cancer metabolism and under low glucose conditions results in rapid tumor cell death. [14] A novel method of cancer therapy is inhibiting the activity of hypoxia-inducible factor 1 (HIF-1) by blocking the transport of glucose into cells, decreasing the conversion of glucose to pyruvate and a concomitant decrease of mitochondrial mass and mitochondrial metabolism. [17] Another oncogene, Myc, in combination with p53 and HIF-1 have a pivotal role in upregulation of proteins in glycolysis and intracellular pH regulation.…”
Section: Metabolism Of Tumor Cellsmentioning
confidence: 99%