Stress urinary incontinence (SUI), a prevalent condition, is represented by an involuntary leakage of urine that results, at least in part, from weakened or damaged pelvic floor muscles and is triggered by physical stress. Current treatment options are limited with no oral therapies available. The pelvic floor is rich in androgen receptor and molecules with anabolic activity including selective androgen receptor modulators (SARMs) may serve as therapeutic options for individuals with SUI. In this study, two SARMs (GTx-024 and GTx-027) were evaluated in a postmenopausal animal model in order to determine their effect on pelvic floor muscles. Female C57BL/6 mice were ovariectomized and their pelvic muscles allowed to regress. The animals were then treated with vehicle or doses of GTx-024 or GTx-027. Animal total body weight, lean body mass, and pelvic floor muscle weights were measured along with the expression of genes associated with muscle catabolism. Treatment with the SARMs resulted in a restoration of the pelvic muscles to the sham-operated weight. Coordinately, the induction of genes associated with muscle catabolism was inhibited. Although a trend was observed towards an increase in total lean body mass in the SARM-treated groups, no significant differences were detected. Treatment of an ovariectomized mouse model with SARMs resulted in an increase in pelvic floor muscles, which may translate to an improvement of symptoms associated with SUI and serves as the basis for evaluating their clinical use. J. Cell. have bladder muscles that can squeeze too often and/or without warning. The dysfunctional bladder will result in a spectrum of symptoms which vary in severity and type. These include increases in urinary frequency and urgency. Accompanying the urgency can be urge urinary incontinence in which the elevated urge results in an involuntary leakage of urine. OAB and its associated symptoms are known to affect more than 33 million people in the United States but estimates have been made that 30% of men and 40% of women live with OAB symptoms with the prevalence increasing with age [FDA, 2015]. The causes of OAB have been mainly attributable to neurological conditions but the broad range of associated symptoms have been linked to other conditions such as urinary tract infections, prostatitis or benign prostatic hyperplasia, and pregnancy [Homma, 2014].As opposed to OAB, in which the bladder muscles are "overactive," stress urinary incontinence (SUI) is a condition in which the pelvic muscles and tissues that support the bladder and urethra have become weak, which can permit the bladder neck to descend during busts of physical activity that increase abdominal pressure including coughing, sneezing, laughing, or exercise. Another cause of SUI, is a weakened sphincter muscle that controls the urethra. SUI occurs predominantly in women and the weakened