Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study

Muratt, Mavi Diehl; Perondi, Beatriz; Greve, Júlia Maria D’Andréa; Roschel, Hamilton; Pinto, Ana Lúcia de Sá; Gualano, Bruno

doi:10.1590/s1807-59322011000700026

Cited by 17 publications

(18 citation statements)

References 11 publications

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“…Previous data from this cohort indicate that exercise intolerance is affected primarily by inactivity; thus, interventions to increase physical activity have the potential to remediate neurocognitive loss among survivors of childhood ALL . Because previous studies have reported reduced levels of activity soon after completion of therapy among survivors of childhood ALL, and because exercise intolerance and neurocognitive impairment begins early in this population, early intervention may be key in reducing neurocognitive decline in survivors. Evidence for this is demonstrated in a meta‐analysis of studies investigating physical activity level and neurocognitive performance among healthy, mentally impaired, or physically disabled school‐age children (ie, 4‐18 years old) .…”

Section: Discussionmentioning

confidence: 86%

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Phillips

Howell

Lanctot

et al. 2019

Cancer

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BACKGROUND: Survivors of childhood acute lymphoblastic leukemia (ALL) are at increased risk for both treatment-related exercise intolerance and neurocognitive deficits. This analysis aimed to identify the association between exercise intolerance and neurocognitive impairments in ALL survivors. METHODS: Cardiopulmonary exercise testing, results from a 2-hour standardized neuropsychological assessment, and self-report questionnaires were obtained for 341 adult survivors of childhood ALL and 288 controls. Multivariable modeling was used to test associations between oxygen uptake at 85% estimated heart rate (rpkVO 2 ) and neuropsychological test and self-reported questionnaire domains, adjusted for sex, age at diagnosis, cranial radiation, anthracycline, and methotrexate exposure and tobacco smoking status. RESULTS: Compared with controls, survivors had worse rpkVO 2 and performance on verbal intelligence, focused attention, verbal fluency, working memory, dominant/nondominant motor speed, visual-motor speed, memory span, and reading and math measures (all P < .001). In adjusted models, exercise intolerance was associated with decreases in performance of verbal ability, focused attention, verbal fluency, working memory, dominant motor speed, nondominant motor speed, visual-motor speed, memory span, reading academics, and math academics in survivors. CONCLUSION: This study demonstrates an association between exercise intolerance and neurocognitive outcomes. Research is needed to determine whether interventions that improve exercise tolerance impact neurocognitive function in ALL survivors. Cancer 2020;126:640-648.

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Section: Discussionmentioning

confidence: 86%

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Phillips

Howell

Lanctot

et al. 2019

Cancer

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“…10,33 In the current pilot study, leg strengthening exercises were specifically targeted, which resulted in clinically important improvement (>5%) in knee extension in 75% of subjects. Although upper body strengthening was only targeted indirectly through general fitness exercises, a mean 17% improvement in hand grip was achieved among all participants.…”

Section: Discussionmentioning

confidence: 98%

“…3,4 Recent data have indicated that these metabolic changes manifest first while patients are still receiving therapy, particularly during maintenance, a two to three year time period that includes pulses of corticosteroid treatment. 5-8 Thus, the period of maintenance therapy, when patients are also found to be deconditioned with decreased muscle strength, 9, 10 appears optimal to develop a preventive intervention. The aim of this pilot study was to determine the feasibility and initial efficacy of an aerobic and strengthening exercise intervention program conducted during maintenance therapy among children treated for ALL.…”

Section: Introduction and Purposementioning

confidence: 99%

Feasibility and Initial Effectiveness of Home Exercise During Maintenance Therapy for Childhood Acute Lymphoblastic Leukemia

Esbenshade

Friedman

Smith

et al. 2014

Pediatric Physical Therapy

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Purpose Children with acute lymphoblastic leukemia (ALL) are at increased risk of obesity and deconditioning from cancer therapy. This pilot study assessed feasibility/initial efficacy of an exercise intervention for ALL patients undergoing maintenance therapy. Methods Participants were children with ALL, age 5-10 years, receiving maintenance therapy, in first remission. A 6-month home-based intervention, with written and video instruction, was supervised with weekly calls from an exercise coach. Pre- and post-study testing evaluated strength, flexibility, fitness and motor function. Results Seventeen patients enrolled (participation 63%). Twelve (71%) finished the intervention, completing 81.7±7.2% of prescribed sessions. Improvements ≥5% occurred in 67% for knee and 75% for grip strength, 58% for hamstring/low-back and 83% for ankle flexibility, 75% for the 6-minute-walk-test, and 33% for performance on the Bruininks-Oseretsky Test of Motor Proficiency Version 2. Conclusions This pilot study demonstrated that exercise intervention during ALL therapy is feasible and has promise for efficacy.

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“…Furthermore, the follow-up duration and tumor localizations as well as the BMI appeared to influence single dimensions of motor performance. Reduced motor performance in pediatric cancer patients has previously been reported, especially in children and adolescents after leukemia therapy [12][13][14][15][16][17][31][32][33] and in a few samples with mixed tumor entities. [6][7][8][9][10][11] According to these earlier findings for hematological tumors and mixed samples, the present study adds new information about the impairment The body mass index is only known in patients who were tested.…”

Section: Discussionmentioning

confidence: 99%

Motor Performance After Treatment for Pediatric Bone Tumors

Kesting

Götte

Seidel

et al. 2015

Journal of Pediatric Hematology/Oncology

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Strength capacity in young patients who are receiving maintenance therapy for acute lymphoblastic leukemia: a case-control study

Cited by 17 publications

References 11 publications

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Physical fitness and neurocognitive outcomes in adult survivors of childhood acute lymphoblastic leukemia: A report from the St. Jude Lifetime cohort

Feasibility and Initial Effectiveness of Home Exercise During Maintenance Therapy for Childhood Acute Lymphoblastic Leukemia

Motor Performance After Treatment for Pediatric Bone Tumors

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