Nutritional and metabolic status of HIV-positive patients with lipodystrophy during one year of follow-up

Abstract

OBJECTIVES:The aim of this prospective study was to compare changes in lipid metabolism and nutritional status after either 6 and 12 months of follow-up in subjects with lipodystrophy syndrome after traditional lifestyle therapy with or without fibric acid analogue intervention (bezafibrate and clofibrate).METHODS:Food intake, alterations in body composition and metabolic abnormalities were assessed in subjects with lipodystrophy syndrome at the beginning of the study. The nutritional status and metabolic alterations of the subjects were monitored, and the subjects received nutritional counseling each time they were seen. The subjects were monitored either two times over a period no longer than six months (Group A; n = 18) or three times over a period of at least 12 months (Group B; n = 35). All of the subjects underwent nutrition counseling that was based on behavior modification. The fibric acid analogue was only given to patients with serum triglyceride levels above 400 mg/dL.RESULTS:After six months of follow-up, Group A showed no alterations in the experimental parameters. After twelve months, there was a decrease in serum triglyceride levels (410.4 ± 235.5 vs. 307.7 ± 150.5 mg/dL, p< 0.05) and an increase in both HDLc levels (37.9 ± 36.6 vs. 44.9 ± 27.9 mg/dL, p<0.05) and lean mass (79.9 ± 7.8 vs. 80.3 ± 9.9 %, p< 0.05) in Group B.CONCLUSION:After one year of follow-up (three sessions of nutritional and medical counseling), the metabolic parameters of the subjects with lipodystrophy improved after traditional lifestyle therapy with or without fibric acid analogue intervention.

Factors associated with undernourishment among people 20 years old or over with HIV/AIDS, attending public health services in the São Paulo municipality, Brazil

“…In addition, recent evidences have shown that individuals with HIV/AIDS are more susceptible to secondary infections and to the early development of advanced signs of frailty in association with chronic inflammation and adverse effects of HAART, making the long-term medical management more difficult 13,14,15,16 . The complexity of HIV infection and its consequences reinforce the need of health-related actions to maintain the nutritional status of this group of patients.…”

“…The complexity of HIV infection and its consequences reinforce the need of health-related actions to maintain the nutritional status of this group of patients. As the subjects of most Brazilian studies on this matter are patients of one single clinic, 13,14,17,18,19,20,21 and few include a higher number of clinics connected to a health care network 15,16,22,23 , the investigations on the nutritional status of HIV/ AIDS individuals, particularly those focusing on undernourishment, in a sample of patients attended in a public healthcare network with facilities broadly distributed over a geographic area, such as the one of the city of São Paulo, Brazil, may contribute for the understanding of this phenomenon.…”

Association between Temporomandibular Dysfunction and Depression in People Living with HIV/AIDS

“…In this study, there was an equal distribution of women (50%) and men (50%). However, in previous studies, the majority of the samples consisted of men, with a frequency varying between 54.6% and 80% [29][30][31][32][33][34][35].…”

Effect of nutritional counseling on low-density lipoprotein cholesterol among Thai HIV-infected adults receiving antiretroviral therapy

“…Little is known about the effect of individual nutritional counseling on lipid profiles of HIV-infected patients when receiving ART in Thailand. Many previous studies in Western countries have shown that lifestyle modification, particularly diet and exercise, reduced dyslipidemia in HIV-infected patients (Anjos et al, 2011; Barrios et al, 2002; Batterham, Brown, & Workman, 2003; Moyle et al, 2001). The majority of these studies implemented menu plans or provided meals for participants in order to compare two or three groups receiving different diets.…”