2011
DOI: 10.1590/s1807-59322011000100023
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Abstract: INTRODUCTION:Internal thoracic artery (ITA) is an established arterial graft for the coronary artery by‐pass surgery. Special micro‐anatomical features of the ITA wall may protect it from age related pathological changes. One of the complications seen after coronary artery bypass grafting is vasospasm. Sympathetic nerves may be involved in vasospasm.OBJECTIVE:To ascertain the sympathetic innervation of the internal thoracic artery and to assess the effect of aging on this artery by histomorphometry.METHOD:Fift… Show more

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Cited by 22 publications
(15 citation statements)
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“…They concluded that preoperative peptide levels > 502 ng/ml predict mid-term mortality after isolated coronary artery bypass grafting and are associated with significantly higher hospital mortality and perioperative complications. Reddy et al [4] analyzed the sympathetic innervation of the internal thoracic artery to assess the effect of aging on this artery by histomorphometry using 54 human internal thoracic artery samples collected from 27 cadavers (19 male and 8 female) with ages of 19 to 83 years. Sympathetic nerve fibers are present in the adventitia of the internal thoracic artery.…”
Section: Kk and Rocha E Silva M -Cardiology In Brazilian Scientific Joumentioning
confidence: 99%
“…They concluded that preoperative peptide levels > 502 ng/ml predict mid-term mortality after isolated coronary artery bypass grafting and are associated with significantly higher hospital mortality and perioperative complications. Reddy et al [4] analyzed the sympathetic innervation of the internal thoracic artery to assess the effect of aging on this artery by histomorphometry using 54 human internal thoracic artery samples collected from 27 cadavers (19 male and 8 female) with ages of 19 to 83 years. Sympathetic nerve fibers are present in the adventitia of the internal thoracic artery.…”
Section: Kk and Rocha E Silva M -Cardiology In Brazilian Scientific Joumentioning
confidence: 99%
“…All muscular arteries appear to exhibit the necessary machinery (i.e., sympathetic perivascular nerves, ␣-adrenergic receptors, etc.) to participate in sympathetic vasoconstriction (11,16,18,28,29,33). Nevertheless, an overwhelming amount of evidence demonstrates that small arteries and arterioles actively respond to all levels of sympathetic activity, whereas it appears that only large reflex-mediated increases in MSNA and infusion of adrenergic agonists raise conduit artery tone (3,23,25,40).…”
Section: Discussionmentioning
confidence: 99%
“…muscle sympathetic nerve activity; blood pressure; large artery vasoconstriction SYMPATHETIC VASOCONSTRICTION is most effective in altering blood flow and blood pressure (BP) by influencing small arteries and arterioles (16, 18). However, conduit arteries also exhibit sympathetic perivascular nerve innervations (11,15,28,33), express ␣-adrenergic receptors (11, 29, 33), and significantly vasoconstrict in response to ␣-adrenergic agonists (3, 40). Indeed, the majority of evidence (2,4,6,23,25,26) suggests that large reflex-mediated increases in muscle sympathetic nerve activity (MSNA) decrease conduit artery diameter, although a few reports indicate only minimal changes (6, 30).…”
mentioning
confidence: 99%
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“…This anatomically medium-sized artery receives sympathetic fibers in its adventitia [28] and has routinely been harvested as a suitable conduit for the myocardium ischaemia relief, showing an increased patency compared to the saphenous vein grafts [34]. During CABG surgery it is important to reassure the conduit length, course, and mobility within the surrounding structures in order to prevent traction and angulation [4].…”
Section: Discussionmentioning
confidence: 99%