Natural coagulation inhibitors and active protein c resistance in preeclampsia

Abstract

INTRODUCTION:The etiology of preeclampsia is not fully established. A few studies have shown a relationship between natural coagulation inhibitors and preeclampsia.OBJECTIVES:The purpose of this study was to investigate the status of natural coagulation inhibitors and active protein C resistance (APC‐R) in preeclampsia.PATIENTS AND METHODS:We studied 70 women with preeclampsia recruited consecutively and 70 healthy pregnant and 70 nonpregnant women as controls. Plasma protein C (PC), free protein S (fPS), antithrombin III (ATIII) and APC‐R were evaluated.RESULTS:ATIII values were found to be significantly lower in preeclamptic patients than in the control groups (p< 0.001). Nevertheless, there was no significant difference between the healthy pregnant and nonpregnant women groups (p = 0.141). The fPS values of the preeclamptic and healthy pregnant groups were lower than that of the nonpregnant group (p< 0.001), and the fPS value of the preeclamptic pregnant women was lower than that of healthy pregnant women (p<0.001). The PC value of the preeclamptic pregnant women was lower than that of the control groups (p< 0.001). The PC value of the healthy pregnant women was lower than that of the nonpregnant women (p< 0.001). The mean APC activity values were lower in the preeclamptic patients than that of the control groups (p< 0.001, p< 0.001). The APC‐R positivity rates of the preeclamptic groups were higher than that of the control groups (p<0.001).CONCLUSIONS:This study demonstrated that ATIII, fPS, PC values and APC resistance were lower and APC‐R positivity was higher in preeclamptic women than in normal pregnant and nonpregnant women.

Associations between pre‐eclampsia and protein C and protein S levels among pregnant Nigerian women

“…A related study in a Turkish population 22 documented that mean levels of free protein S was significantly reduced among women with pre-eclampsia as compared with normotensive pregnant and nonpregnant women; however, the study did not report how many women had a deficiency in free protein S. The present study found higher mean levels of free protein S among women with pre-eclampsia, but a higher incidence of free protein S deficiency in the same women than among normotensive pregnant women.…”

Association of antithrombin-III and platelet count with pregnancy induced hypertension

“…21 In our study, the plasma AT-III levels of normal pregnant women as compared to healthy non-pregnant women were lower but the difference was not statistically significant. This was in consistent with the study done by Maryam-Sadat Hosseini et al 22 In our study and in the other studies, 23,24 performed on preeclamptic pregnant women; AT-III levels were significantly lower than those of healthy non-pregnant and normal pregnant women. Our study reveals that as compared to mild preeclamptic group, the lower levels of AT-III in severe preeclamptic…”

Serum proteins differentially expressed in early- and late-onset preeclampsia assessed using iTRAQ proteomics and bioinformatics analyses

“…Owing to the activation of the intrinsic and exogenous coagulation pathways by damaged endothelial cells, a large number of coagulation factors are activated. This leads to a massive generation of thrombin, which antagonizes a large amount of anti-thrombin III, resulting in a significant decrease in its level (Demir & Dilek, 2010;Pottecher et al, 2009). In response to abnormalities in the coagulation mechanism of PE, evidence-based medical study has also shown that oral administration of low-dose aspirin during early pregnancy can significantly reduce the incidence rate of PE (Rolnik et al, 2017).…”