2010
DOI: 10.1590/s1807-59322010000200012
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Abstract: INTRODUCTIONThe antibacterial effect of ozone (O3) has been described in the extant literature, but the role of O3 therapy in the treatment of certain types of infection remains controversial.OBJECTIVESTo evaluate the effect of intraperitoneal (i.p.) O3 application in a cecal ligation/puncture rat model on interleukins (IL-6, IL-10) and cytokine-induced neutrophil chemoattractant (CINC)-1 serum levels, acute lung injury and survival rates.METHODSFour animal groups were used for the study: a) the SHAM group und… Show more

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Cited by 37 publications
(26 citation statements)
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“…Since O 3 therapy induces oxidation in the body, the activities of antioxidant enzymes such as SOD are increased subsequent to O 3 treatment (5,31). In the experimental septic rat model, the therapeutic effect of O 3 treatment in the rectum was confirmed (32). Our results show the ozonated water also exhibit antioxidative and anti-inflammatory activities.…”
Section: Discussionsupporting
confidence: 58%
“…Since O 3 therapy induces oxidation in the body, the activities of antioxidant enzymes such as SOD are increased subsequent to O 3 treatment (5,31). In the experimental septic rat model, the therapeutic effect of O 3 treatment in the rectum was confirmed (32). Our results show the ozonated water also exhibit antioxidative and anti-inflammatory activities.…”
Section: Discussionsupporting
confidence: 58%
“…9 In addition, there is reactivation of the cerebral microcirculation and metabolism, 7 an anti-ischemic protective effect, [10][11][12] antithrombotic effect, 13 and anti-tumor action.…”
Section: Introductionmentioning
confidence: 99%
“…The chemical properties of ozone are utilized in ozone therapy to treat infected wounds, decubitus ulcers, burns, ulcerations, inflammation of skin and bone tissue, or radiation therapy-related changes in cancer patients. Ozone therapy is also used to treat inflammation and infections of certain internal organs, especially when antibiotic therapy has failed to control multidrug-resistant bacteria [4,5]. …”
Section: Introductionmentioning
confidence: 99%