2010
DOI: 10.1590/s1807-59322010000100014
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Abstract: INTRODUCTION:There is little data concerning the ability of Eurycoma longifolia Jack (EL) to reverse the inhibitory effects of estrogen on testosterone production and spermatogenesis. The aim of the present study was to determine the effect of EL on testicular histology and sperm count in estrogen-treated male rats.METHODS:Adult male Sprague-Dawley rats weighing 200–250 g were divided into four groups of six rats each. Group A (control) was given solvent in the same manner as the treated groups were given EL. … Show more

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Cited by 63 publications
(43 citation statements)
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“…Furthermore, the dose was nearly twice the dose of EL used to increase sperm counts in normal rats (Wahab et al 2010).…”
Section: Discussionmentioning
confidence: 94%
“…Furthermore, the dose was nearly twice the dose of EL used to increase sperm counts in normal rats (Wahab et al 2010).…”
Section: Discussionmentioning
confidence: 94%
“…E. longifolia ingestion may also affect testosterone production [12]. Similarly, H. epimedii (‘horny goat weed’), which is typically ingested for its aphrodisiac properties [13], may also mimic the effects of testosterone [14].…”
Section: Discussionmentioning
confidence: 99%
“…Hormonal disturbances such as excess of estrogen can cause inhibitory effect on testosterone and disturb testicular function. Wahab et al (2010) investigated the effect of E. longifolia on testicular histology and sperm count in estrogen-treated male rats. They discovered that E. longifolia could heightens testicular function and reverse the effect of excessive estrogen as rats treated with E. longifolia showed higher sperm count and mortality.…”
Section: Pharmacological Effectmentioning
confidence: 99%
“…longifolia or commonly known in Malaysia and internationally as Tongkat Ali is most famous and notorious for its sexual enhancing property, however, in literatures, the compound that is responsible for the property is surprisingly unknown yet. As such most of the studies are conducted on extracts only (Ang and Sim, 1998;Ang et al, 2001Ang et al, , 2003Ang et al, , 2004aWahab et al, 2010;Abdulghani et al, 2012), root powder (Zanoli et al, 2009) and quassinoid rich fraction (Low et al, 2013). However, Sambandan et al (2006) and Asiah et al (2007) identified a bioactive peptide of 4.3 kDA, labelled as eurypeptide, which enhance synthesis of various androgens.…”
Section: Phytochemical Testmentioning
confidence: 99%